{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:06:31Z","timestamp":1779307591956,"version":"3.51.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"publisher","award":["2021-0002"],"award-info":[{"award-number":["2021-0002"]}],"id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"publisher","award":["2022-0001"],"award-info":[{"award-number":["2022-0001"]}],"id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Easily obtainable biomarkers for non-infectious, inflammatory central nervous system (CNS) disorders in dogs are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Dogs with non-infectious inflammatory CNS disorders might have specific neural autoantibodies in serum or cerebrospinal fluid (CSF), or both, discoverable by commercially available indirect immunofluorescence (IIF) assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Dogs (n\u00a0=\u00a023) with non-infectious inflammatory CNS disorders, including meningoencephalomyelitis of unknown origin, were recruited from the University Hospital for Companion Animals (Copenhagen, Denmark).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using an exploratory, prospective study design, serum and CSF from dogs were investigated for specific neural autoantibodies with cell- and tissue-based IIF assays used to identify neural autoantibodies in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Astrocytic autoantibodies against glial fibrillary acidic protein were present in 2 dogs, neuronal targeted autoantibodies against N-methyl-D-aspartate receptors (NMDAR) in 2 dogs, and tripartite motif-containing protein 46 in 1 dog. Additionally, autoantibodies toward myelin were suspected in 6 dogs and myelin-oligodendrocyte glycoprotein in 4 dogs. Autoantibodies against a neuronal surface structure were suspected in 1 dog but could not be further specified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>This study confirmed the presence of neural autoantibodies in several dogs with non-infectious inflammatory CNS disorders. The importance of both tissue- and cell-based assays (CBA) is emphasized by the fact that all specific autoantibodies apart from those targeting NMDAR were detected by tissue-based assays and then confirmed on cell-based assays (CBA).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag086","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:20:20Z","timestamp":1779304820000},"source":"Crossref","is-referenced-by-count":0,"title":["Detection of neural autoantibodies in dogs with non-infectious inflammatory central nervous system disorders"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5259-5057","authenticated-orcid":false,"given":"Pernille L","family":"Heidemann","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , 1870 Frederiksberg C 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