{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:54:51Z","timestamp":1781826891666,"version":"3.54.5"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":48,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Calvarial multilobular tumor of bone (MLTB) in dogs is treated typically by craniectomy. However, long-term outcome data are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To describe the clinical features and long-term outcomes of dogs with surgically treated calvarial MLTB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fifty client-owned dogs with surgically excised, histopathologically confirmed calvarial MLTB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case series of surgically resected calvarial MLTB in dogs. Signalment, clinical and imaging findings, surgical technique, complications, histopathological grade, and outcome (survival, progression) were recorded. Kaplan\u2013Meier survival analysis was performed. Possible prognostic factors were evaluated by Cox proportional hazards modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most dogs were neurologically normal (33\/50; 66%) at presentation. Tumors commonly involved the parietal (30\/50; 60%) and frontal (29\/50; 58%) bones and venous sinuses (23\/50; 46%). Intraoperative complications (11\/50; 22%) included hemorrhage and cerebral swelling; postoperative complications (20\/50; 40%) included hypotension, seizures, and transient neurological deterioration. Most dogs (31\/50; 62%) had grade I tumors, while the remaining had high-grade (17\/50; 34% grade II; 2\/50 grade III) tumors. High-tumor grade was associated with progression (HR 19.0; 95% CI, 4.1-88.4; P\u00a0&amp;lt;\u00a0.001) and cancer-specific death (HR 3.3; 95% CI, 1.1-9.7; P\u00a0=\u00a0.03). En bloc resection was associated with reduced progression (HR 0.1; 95% CI, 0.02-0.3; P\u00a0&amp;lt;\u00a0.001). Median cancer-specific survival time was 1005\u00a0days (range 1-1088\u00a0days) with 1 dog alive at 3165\u00a0days. Median progression-free interval was 448\u00a0days (range 53-1236\u00a0days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Long survival and progression-free intervals are common. En bloc resection should be attempted and might reduce recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag120","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:45:55Z","timestamp":1781826355000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics, advanced imaging findings, and long-term outcomes in 50 dogs with calvarial multilobular tumor of bone treated with craniectomy"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-9593","authenticated-orcid":false,"given":"Vishal D","family":"Murthy","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis , Davis, CA ,","place":["United States"]},{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University , Pullman, WA ,","place":["United 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Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University , Blacksburg, VA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J","family":"Kenny","sequence":"additional","affiliation":[{"name":"Small Animal Specialist Hospital , North Ryde, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie V","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University , Pullman, WA ,","place":["United States"]},{"name":"Veterinary Referral Center of Central Oregon , Bend, OR ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chai-Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis , Davis, CA ,","place":["United States"]},{"name":"Animal Medical Center of Seattle , Shoreline, WA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Dickinson","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis , Davis, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Vernau","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis , Davis, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly K","family":"Sturges","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis , Davis, CA 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