{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:50:10Z","timestamp":1793253010397,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Project of Jiangsu Agri-animal Husbandry Vocational College, China","award":["NSF2024JB03"],"award-info":[{"award-number":["NSF2024JB03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cow placenta extract (CPE) has demonstrated beneficial effects in antiaging; however, its effect on age-related cognitive decline remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To evaluate the potential therapeutic benefits of CPE in improving cognitive function in aged dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>The aged dogs (\u22657\u00a0years) with a Canine Social and Learning Behavior Survey (CSLB) score of \u2265 30 owned by clients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 6-month randomized controlled trial. Eighty-eight dogs received CPE (n\u00a0=\u00a045) or placebo (n\u00a0=\u00a043). Canine Social and Learning Behavior Survey questionnaires were administered, and serum oxidative stress markers were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By month 6, the mean\u00a0\u00b1\u00a0SD of CSLB was 35.1\u00a0\u00b1\u00a04.9 in the CPE group vs 41.1\u00a0\u00b1\u00a05.3 (P\u00a0&amp;lt;\u00a0.05; Cohen\u2019s d\u00a0=\u00a0\u22121.17; 95% CI for d: \u22121.63 to \u22120.72) in the placebo group. The successful therapeutic response was 77.8% (95% CI, 63.2-88.0) in the CPE group vs 9.3% (95% CI, 3.1-22.3; P\u00a0&amp;lt;\u00a0.001) in the placebo group. The correlation between the change (\u0394%) in CSLB and change in malondialdehyde (MDA) was positive (r\u00a0=\u00a00.77, P\u00a0&amp;lt;\u00a0.001), and correlations between the \u0394% in CSLB and change in glutathione peroxidase (GSH-Px) and glutathione (GSH) were negative (r\u00a0=\u00a0\u22120.893, P\u00a0&amp;lt;\u00a0.001 and r\u00a0=\u00a0\u22120.878, P\u00a0&amp;lt;\u00a0.001, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>A six-month CPE administration improved cognitive function and oxidative stress in aged dogs, suggesting its potential for long-term management of cognitive impairment.<\/jats:p>\n                  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