{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:14:04Z","timestamp":1784232844650,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Atat\u00fcrk University Scientific Research Projects Coordination Unit","award":["TDK-2021\u20139842"],"award-info":[{"award-number":["TDK-2021\u20139842"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) in cats is characterized by oxidative stress, inflammation, and apoptosis. Curcumin has shown renoprotective effects in experimental models, but clinical evidence in cats with CKD remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Evaluate whether PO curcumin supplementation (80\u00a0mg\/cat\/day), administered with standard treatment, favorably modulates renal, oxidative, inflammatory, and apoptotic biomarkers in cats with International Renal Interest Society (IRIS) stage 3 CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixteen client-owned cats with IRIS stage 3 CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, randomized trial. Cats were allocated to medical treatment alone (MT; n\u00a0=\u00a08) or medical treatment plus curcumin (MT\u00a0+\u00a0C; n\u00a0=\u00a08). Curcumin was administered PO at 80\u00a0mg\/cat\/day in 2 divided doses for 60\u00a0days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline renal biomarkers did not differ between groups. The primary outcome, serum symmetric dimethylarginine (SDMA) concentration, was significantly lower in the MT\u00a0+\u00a0C group than in the MT group on days 30, 45, and 60 (P\u00a0&amp;lt;\u00a0.01). Urinary protein-to-creatinine ratio decreased over time in the MT\u00a0+\u00a0C group and was lower than in the MT group at later time points. Total antioxidant status increased, whereas total oxidant status decreased in the MT\u00a0+\u00a0C group, with a significant between-group difference in total oxidant status on day 45. Findings for nuclear factor kappa B and caspase-3 were also consistent with decreased inflammatory and apoptotic activity in curcumin-treated cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Curcumin supplementation was associated with improvement in SDMA and favorable changes in mechanistic biomarkers in cats with IRIS stage 3 CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag138","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:51:32Z","timestamp":1784231492000},"source":"Crossref","is-referenced-by-count":0,"title":["Renoprotective effects of curcumin in cats with chronic kidney disease"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0062-2825","authenticated-orcid":false,"given":"Murat","family":"\u0130lg\u00fcn","sequence":"first","affiliation":[{"name":"Pethome Veterinary Polyclinic , Istanbul 34290 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-5757","authenticated-orcid":false,"given":"Mustafa Sinan","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine, Atat\u00fcrk University , Erzurum 25240 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026071615512955900_ref1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cvsm.2010.09.004","article-title":"Chronic kidney disease in small animals","volume":"41","author":"Polzin","year":"2011","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026071615512955900_ref2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/0300985812453176","article-title":"Histomorphometry of feline chronic kidney disease and correlation with markers of renal dysfunction","volume":"50","author":"Chakrabarti","year":"2013","journal-title":"Vet Pathol"},{"key":"2026071615512955900_ref3","author":"International Renal Interest Society","year":"2016"},{"key":"2026071615512955900_ref4","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/j.1939-1676.2007.tb03042.x","article-title":"Benr\u0131c (benazepril in renal insufficiency in cats) study group. 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