{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:05:32Z","timestamp":1783980332943,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 7-month-old spayed female mixed-breed dog was evaluated for a subacute, progressive, cerebellar syndrome characterized by ataxia and intention tremors. Brain magnetic resonance imaging (MRI) revealed moderate cerebellar atrophy and mild bilateral symmetrical intra-axial lesions at the level of the caudate nuclei. A neurodegenerative disorder was suspected. Over a 2-year period, signs of neurologic disease worsened with suspected myoclonic epileptic seizures and severe cerebellar ataxia. Follow-up MRI showed progressive cerebellar and cerebral atrophy, as well as well-defined, bilateral, and symmetrical lesions affecting the caudate nuclei. Histopathology revealed severe cerebellar degeneration with a loss of Purkinje cells and depletion of the granular and molecular layers. Malacic areas at the level of the caudate nuclei characterized by extensive necrosis were observed. Genetic testing identified a clear top candidate variant in the SERAC1 gene on chromosome 1. These findings are consistent with multiple system degeneration, a rare inherited neurodegenerative disorder resembling MEGD(H)EL syndrome (3-methylglutaconic aciduria with deafness-dystonia, [hepatopathy], encephalopathy, and Leigh-like syndrome) in humans.<\/jats:p>","DOI":"10.1093\/jvimsj\/aalag141","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:40:28Z","timestamp":1783978828000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical, imaging, and neuropathological characterization of multiple system degeneration associated with a novel\n                    <i>SERAC1<\/i>\n                    variant in a mixed-breed dog"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1832-9691","authenticated-orcid":false,"given":"Tania","family":"Al Kafaji","sequence":"first","affiliation":[{"name":"Veterinary Neurologic Center \u201cLa Fenice\u201d , 09047 Selargius ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7986-7258","authenticated-orcid":false,"given":"\u00c7a\u011fla","family":"Ayta\u015f","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Pisa , 56124 Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4119-1956","authenticated-orcid":false,"given":"Assami-Carina","family":"Perret","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty, University of Bern , 3001 Bern ,","place":["Switzerland"]},{"name":"Graduate School for Cellular and Biomedical Sciences, University of Bern , 3012 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-0041","authenticated-orcid":false,"given":"Vidhya","family":"Jagannathan","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty, University of Bern , 3001 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-4880","authenticated-orcid":false,"given":"Tosso","family":"Leeb","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty, University of Bern , 3001 Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-6449","authenticated-orcid":false,"given":"Carlo","family":"Cantile","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Pisa , 56124 Pisa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5772-2712","authenticated-orcid":false,"given":"Antonella","family":"Gallucci","sequence":"additional","affiliation":[{"name":"Veterinary Neurologic Center \u201cLa Fenice\u201d , 09047 Selargius ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"2026071317401608700_ref1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2026071317401608700_ref2","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.2460\/javma.1976.168.12.1119","article-title":"Hereditary cerebellar cortical and extrapyramidal nuclear abiotrophy in Kerry Blue Terriers","volume":"168","author":"deLahunta","year":"1976","journal-title":"J Am Vet Med Assoc"},{"key":"2026071317401608700_ref3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1177\/03009858211043088","article-title":"Pathologic characterization of canine multiple system degeneration in the Ibizan hound","volume":"59","author":"St Jean","year":"2022","journal-title":"Vet Pathol"},{"key":"2026071317401608700_ref4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/00005072-198405000-00005","article-title":"Hereditary striatonigral and cerebello-olivary degeneration of the Kerry Blue Terrier. 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