{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:02:23Z","timestamp":1784754143673,"version":"3.55.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 4-year-old male castrated domestic shorthair cat was diagnosed with a urethral obstruction after presenting for vomiting, inappetence, and inappropriate urination. The cat developed iatrogenic hypercalcemia (ionized calcium &amp;gt;\u20094\u00a0mmol\/L, total calcium 57\u00a0mg\/dL) and an acute kidney injury (creatinine 9.81\u00a0mg\/dL) suspected to be a consequence of an overdose of calcium gluconate. Approximately 12\u00a0h after admission, the cat became comatose and developed cardiovascular instability. A 6-h hemodialysis treatment was performed using continuous venovenous hemodiafiltration on the Prismaflex platform and hypercalcemia resolved during treatment. The cat\u2019s creatinine normalized (1.01\u00a0mg\/dL) within 72\u00a0h and the cat was discharged after 6\u00a0days of hospitalization. The cat subsequently developed signs of upper respiratory and gastrointestinal disease. Diagnostics including upper gastrointestinal endoscopy and bronchoscopy showed evidence of diffuse calcification of the trachea and gastric mucosa. This case demonstrates the successful application of hemodialysis in veterinary medicine to treat an acute kidney injury and iatrogenic hypercalcemia and provides unique documentation of its potential long-term sequelae.<\/jats:p>","DOI":"10.1093\/jvimsj\/aalag142","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:06:50Z","timestamp":1784750810000},"source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment of severe iatrogenic hypercalcemia and acute kidney injury with hemodialysis in a cat"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7769-0677","authenticated-orcid":false,"given":"Lauren A","family":"DelMaestro","sequence":"first","affiliation":[{"name":"BluePearl Pet Hospital , Levittown, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca T","family":"Bernstein","sequence":"additional","affiliation":[{"name":"BluePearl Pet Hospital , Levittown, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9966-5376","authenticated-orcid":false,"given":"Peter S","family":"Chapman","sequence":"additional","affiliation":[{"name":"BluePearl Pet Hospital , Levittown, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-4443","authenticated-orcid":false,"given":"Nolan V","family":"Chalifoux","sequence":"additional","affiliation":[{"name":"BluePearl Pet Hospital , Levittown, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"2026072216064467500_ref1","doi-asserted-by":"publisher","first-page":"e1629","DOI":"10.1002\/vetr.1629","article-title":"Type and impact of clinical incidents identified by a voluntary reporting system covering 130 small animal practices in mainland Europe","volume":"191","author":"Schortz","year":"2022","journal-title":"Vet Rec"},{"key":"2026072216064467500_ref2","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.2460\/javma.23.07.0370","article-title":"Patient safety culture is needed in veterinary medicine","volume":"261","author":"Hofmeister","year":"2023","journal-title":"J Am Vet Med Assoc"},{"key":"2026072216064467500_ref3","doi-asserted-by":"publisher","first-page":"106092","DOI":"10.1016\/j.tvjl.2024.106092","article-title":"International renal interest society best practice consensus guidelines for intermittent hemodialysis in dogs and cats","volume":"305","author":"Segev","year":"2024","journal-title":"Vet J"},{"key":"2026072216064467500_ref4","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.cvsm.2025.01.009","article-title":"Extracorporeal therapies in the emergency room and intensive care unit","volume":"55","author":"Londo\u00f1o","year":"2025","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026072216064467500_ref5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/B978-1-4377-0654-3.00029-9","volume-title":"Fluid, Electrolyte, and Acid Base Disorders in Small Animal Practice","author":"Langston","year":"2012","edition":"4th"},{"key":"2026072216064467500_ref6","year":"2004"},{"key":"2026072216064467500_ref7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/B978-1-4377-0654-3.00013-5","volume-title":"Fluid, Electrolyte, and Acid Base Disorders in Small Animal Practice","author":"Schenck","year":"2012","edition":"4th"},{"key":"2026072216064467500_ref8","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/vsu.13984","article-title":"Effect of metastatic calcification on complication rate and survival in 74 renal transplant cats (1998-2020)","volume":"52","author":"Friday","year":"2023","journal-title":"Vet Surg"},{"key":"2026072216064467500_ref9","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1292\/jvms.66.1133","article-title":"Severe calcification of mucocutaneous and gastrointestinal tissues induced by high dose administration of vitamin D in a puppy","volume":"66","author":"Nakamura","year":"2004","journal-title":"J Vet Med Sci"},{"key":"2026072216064467500_ref10","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1354\/vp.37-5-490","article-title":"Metastatic calcification in a dog attributable to ingestion of a tacalcitol ointment","volume":"37","author":"Hilbe","year":"2000","journal-title":"Vet Pathol"},{"key":"2026072216064467500_ref11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/BF03160947","article-title":"A fatal case of iatrogenic hypercalcemia after calcium channel blocker overdose","volume":"4","author":"Sim","year":"2008","journal-title":"J Med Toxicol"},{"key":"2026072216064467500_ref12","doi-asserted-by":"publisher","first-page":"P178","DOI":"10.1186\/cc1638","article-title":"Plasma-lyte\u00ae as dialysate for CRRT: institution of a new therapy and initial evaluation","volume":"6","author":"McCunn","year":"2002","journal-title":"Crit Care"},{"key":"2026072216064467500_ref13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.5492\/wjccm.v5.i4.235","article-title":"Plasma-Lyte 148: a clinical review","volume":"5","author":"Weinberg","year":"2016","journal-title":"World J Crit Care Med"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/40\/4\/aalag142\/69806295\/aalag142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/40\/4\/aalag142\/69806295\/aalag142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:06:51Z","timestamp":1784750811000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/doi\/10.1093\/jvimsj\/aalag142\/8740064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jvimsj\/aalag142","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7,1]]},"article-number":"aalag142"}}