{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:46:58Z","timestamp":1785746818383,"version":"3.56.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypoalbuminemia (HA) is associated with a higher case fatality rate in people.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To describe the affected organ systems and pathoetiologies in cats with mild (2.5-2.9\u00a0g\/dL), moderate (2-2.4\u00a0g\/dL), or severe (&amp;lt; 2\u00a0g\/dL) HA, and compare hospitalization and survival times to cats without HA (wHA; \u2265 3\u00a0g\/dL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eight hundred thirty-two HA and 832 wHA cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case-control study of cats with plasma albumin concentrations measured between 2017 and 2023. Diagnoses were categorized by organ system and pathoetiology and subsequently compared among HA and wHA groups. Hospitalization and survival times were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HA prevalence was 32% (948\/2927); 116 cats were excluded. Cats with HA were more often diagnosed with infectious (211\/832, 25%) or neoplastic (198\/832, 24%) pathoetiologies, and diseases affecting the hematopoietic (140\/832, 17%) or multisystemic (71\/832, 9%) organ systems compared to cats wHA (P\u00a0&amp;lt;\u00a0.001 for all). Cats with severe HA were more likely to have infectious diseases than all other severities (P\u00a0&amp;lt;\u00a0.001). Cats with HA had longer hospitalizations and shorter survival than wHA cats (P\u00a0&amp;lt;\u00a0.001). Cats with severe HA had significantly shorter restricted mean survival times from admission to 6 months (71\u00a0days, 95% CI 51-92\u00a0days) than wHA (144\u00a0days, 95% CI 138-149\u00a0days, P\u00a0&amp;lt;\u00a0.001), mild HA (119\u00a0days, 95% CI 111-127, P\u00a0&amp;lt;\u00a0.001), and moderate HA (108\u00a0days, 95% CI 95-122\u00a0days, P\u00a0=\u00a0.02) cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>In cats with severe HA, investigation of infectious diseases should be prioritized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag146","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:12:32Z","timestamp":1785744752000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of hypoalbuminemia with disease and survival in 1664 cats presenting to a tertiary teaching hospital: a retrospective case-control study"],"prefix":"10.1093","volume":"40","author":[{"given":"Conner C","family":"Hayes","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996, \u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-8968","authenticated-orcid":false,"given":"Xiaojuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Office of Innovative Technologies, University of Tennessee , Knoxville, TN 37919, \u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-1422","authenticated-orcid":false,"given":"Paolo","family":"Pazzi","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996, \u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-3591","authenticated-orcid":false,"given":"Sarah M","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee , Knoxville, TN 37996, \u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026080304122740500_ref1","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1111\/jsap.13764","article-title":"Hypoalbuminaemia and its association with disease and clinical outcomes in cats","volume":"65","author":"Fong","year":"2024","journal-title":"J Small Anim Pract"},{"key":"2026080304122740500_ref2","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/s0895-4356(97)00015-2","article-title":"Association of serum albumin and mortality risk","volume":"50","author":"Goldwasser","year":"1997","journal-title":"J Clin Epidemiol"},{"key":"2026080304122740500_ref3","doi-asserted-by":"publisher","first-page":"12:6017","DOI":"10.3390\/jcm12186017","article-title":"Serum albumin levels: a biomarker to be repurposed in different disease settings in clinical practice","author":"Gremese","year":"2023","journal-title":"J Clin Med"},{"key":"2026080304122740500_ref4","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/01.SLA.0000055547.93484.87","article-title":"Hypoalbuminemia in acute illness: is there a rationale for intervention? 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