{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T21:28:37Z","timestamp":1786397317914,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Koster Collaborative Project Fund"},{"DOI":"10.13039\/100007235","name":"Colorado State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Right-sided heart disease (RHD) affects gastrointestinal function and hemostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Dogs with progressively severe RHD have impaired gastrointestinal function and altered hemostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eighteen client-owned dogs with RHD; group 1: 6 dogs without hepatic venous congestion, group 2: 6 dogs with hepatic venous congestion but no ascites, and group 3: 6 dogs with ascites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, cross-sectional, exploratory study. Dogs underwent routine blood, urine, and fecal testing, measures of gastrointestinal health, coagulation testing, C-reactive protein (CRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and comprehensive echocardiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Right atrial area higher from groups 1 to 3 (1.34\u00a0\u00b1\u00a00.66, 2.48\u00a0\u00b1\u00a01.33, 3.1\u00a0\u00b1\u00a00.93\u00a0cm2\/kg0.71; P\u00a0=\u00a0.02). NT-proBNP (median; range) higher across group 1 (821; 493-3016\u00a0pmol\/L), group 2 (1694; 1125-8117\u00a0pmol\/L), and group 3 (5165; 3492-10\u2009000\u00a0pmol\/L) (P\u00a0=\u00a0.006). Measures of gastrointestinal dysfunction including serum methylmalonic acid (group 1\u00a0=\u00a0857.5\u00a0\u00b1\u00a0322.6; group 2\u00a0=\u00a01031.1\u00a0\u00b1\u00a0222.5; and group 3\u00a0=\u00a01460.5\u00a0\u00b1\u00a0516.3\u00a0nmol\/L; P\u00a0=\u00a0.037) and intestinal fatty acid binding protein (group 1 median\u00a0=\u00a09.3, range\u00a0=\u00a05.6-11.5; group 2\u00a0=\u00a010.1, 8.0-20.4; and group 3\u00a0=\u00a013.8, 10.3-17.5\u00a0ng\/mL) were worse in more severely affected dogs (P\u00a0=\u00a0.032). Hyperfibrinolysis was observed with worsening RHD (none in group 1, 2 in group 2, and 3 in group 3). Activated partial thromboplastin time was higher with disease severity. No difference was detected among groups in cobalamin, folate, or CRP (all P\u00a0&amp;gt;\u00a0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Clinicians should be aware of derangements within the gut\u2013heart axis and coagulation system when managing dogs with RHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag160","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T20:43:00Z","timestamp":1786394580000},"source":"Crossref","is-referenced-by-count":0,"title":["Assessment of gastrointestinal health and the coagulation system in dogs with right-sided heart disease: an exploratory study"],"prefix":"10.1093","volume":"40","author":[{"given":"Sarah","family":"Shropshire","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and 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