{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:47Z","timestamp":1786119467892,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although glomerular disorders contribute to chronic kidney disease in dogs, few studies have evaluated the usefulness of renal biopsy for predicting outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Investigate morphologic diagnoses, clinicopathological findings, comorbidities, treatment, and their associations with survival in dogs after renal biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred ten client-owned dogs with glomerular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of medical records from the European Veterinary Renal Pathology Service (2018-2023). Data were obtained before referral for renal biopsy and during follow-up. Survival analysis was performed using the Kaplan\u2013Meier method, followed by log-rank tests. Relative risk was calculated using contingency tables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs were classified into 3 groups: immune complex glomerulonephritis (ICGN) (61 dogs, 56%), non-ICGN (39 dogs, 35%), and juvenile nephropathy (JN) (10 dogs, 9%). Survival was longer in ICGN dogs than non-ICGN (mean\u00a0\u00b1\u00a0SEM: 951\u00a0\u00b1\u00a078\u00a0days vs. 613\u00a0\u00b1\u00a092\u00a0days; P\u00a0=\u00a0.02), with no difference versus JN (1004\u00a0\u00b1\u00a0169). No survival differences were observed among the morphological subtypes of ICGN. Dogs with amyloidosis had shorter survival than all other morphologic non-ICGN subtypes (384\u00a0\u00b1\u00a095 vs. 650\u00a0\u00b1\u00a056\u00a0days, P\u00a0=\u00a0.02). Risk of a creatinine increase of \u226550% during follow-up was greater in the JN group (RR\u00a0=\u00a02.78; 95% CI, 1.60-4.84; P\u00a0=\u00a0.03). Reduction in proteinuria \u226550% during follow-up did not differ between groups. Immunosuppressive treatment was more frequently administered to ICGN dogs (P\u00a0&amp;lt;\u00a0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Immune complex glomerulonephritis dogs had better outcomes and slower disease progression than non-ICGN and JN. Proteinuria decreased by approximately 50% within each group over time; however, the retrospective design precludes conclusions regarding the effect of antiproteinuric treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag161","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:36:04Z","timestamp":1786041364000},"source":"Crossref","is-referenced-by-count":0,"title":["Survival of dogs with glomerular disease in Europe: insights from the European Veterinary Renal Pathology Service"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-1297","authenticated-orcid":false,"given":"Eric","family":"Zini","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , 8057 Zurich ,","place":["Switzerland"]},{"name":"Department of Animal Medicine, Production and Health, University of Padova , 35020 Legnaro 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,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-5007","authenticated-orcid":false,"given":"Donatella","family":"Gelli","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health, University of Padova , 35020 Legnaro ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-5035","authenticated-orcid":false,"given":"Barbara","family":"Contiero","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health, University of Padova , 35020 Legnaro ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-6458","authenticated-orcid":false,"given":"Francesco","family":"Dondi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna , 40064 Ozzano dell'Emilia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-1740","authenticated-orcid":false,"given":"Luca","family":"Aresu","sequence":"additional","affiliation":[{"name":"MYLAV, Laboratorio La Vallonea , 20017 Passirana di Rho ,","place":["Italy"]},{"name":"Department of Veterinary Science, University of Turin , 10095 Grugliasco ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"2026080614355636200_ref1","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/ki.1986.120","article-title":"Canine chronic renal disease: prevalence and types of glomerulonephritis in the dog","volume":"29","author":"Macdougall","year":"1986","journal-title":"Kidney 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