{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:19:52Z","timestamp":1786119592054,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Cat\u00f3lica de Valencia \u201cSan Vicente M\u00e1rtir\u201d"},{"name":"UCV Open Science program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited information is available regarding comparison between clinical outcomes and post-treatment imaging findings in cats with the neurologic form of feline infectious peritonitis (FIP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objective<\/jats:title>\n                    <jats:p>Describe post-treatment imaging findings and clinical outcomes in cats with neurologic FIP treated with antiviral drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Nine cats with a presumptive diagnosis of neurologic FIP undergoing advanced imaging before and after antiviral treatment (GS-441524, remdesivir, or both).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records from 8 institutions were reviewed retrospectively (January 1, 2020 to December 31, 2024). Included cats had pre- and post-treatment magnetic resonance imaging (MRI) or computed tomography (CT) studies. Treatments consisted of GS-441524 (6\/9), remdesivir (2\/9), or both (1\/9). All cats received corticosteroids. Follow-up imaging was performed at variable time points after completion of antiviral treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Central vestibular disease was the most common neuroanatomical localization (6\/9). Obstructive hydrocephalus was present in all cases on initial and follow-up imaging. Cerebrospinal fluid analysis, available in 4 cats, included pleocytosis (neutrophilic in 3\/4; lymphocytic in 1\/4). Complete clinical recovery occurred in 5\/9 cats. Four of 9 had residual neurologic deficits and 2\/9 experienced recurrence of neurologic signs. None showed complete resolution of imaging abnormalities. Imaging changes did not consistently reflect clinical outcomes. In 4\/9 cats, progression of obstructive hydrocephalus was observed, including cases with clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Clinical improvement is not always consistent with radiologic resolution in cats with neurologic FIP treated with antivirals. Post-treatment MRI findings, particularly persistent or worsening obstructive hydrocephalus, should be interpreted alongside clinical status rather than as a sole indicator of therapeutic response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag162","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:36:03Z","timestamp":1786041363000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical and imaging findings after antiviral treatment in cats with presumptive neurologic feline infectious peritonitis: 9 cases (2020-2024)"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2740-2730","authenticated-orcid":false,"given":"Cristian","family":"Santos Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Hospital Veterinario Universidad Cat\u00f3lica de Valencia \u201cSan Vicente M\u00e1rtir\u201d , Avenida de P\u00e9rez Gald\u00f3s, 51, 46018 Valencia ,","place":["Spain"]},{"name":"Unavets Veterios Referral Veterinary Hospital , C. Arrastaria, 23, 28022 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Mart\u00ednez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unavets Veterios Referral Veterinary Hospital , C. 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Tajo, s\/n, 28670 Villaviciosa de Od\u00f3n, Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-3780","authenticated-orcid":false,"given":"Luciano","family":"Espino","sequence":"additional","affiliation":[{"name":"Hospital Veterinario Rof Codina, Universidad de Santiago de Compostela , Estrada da Granxa, 51, 27002 Lugo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-1812","authenticated-orcid":false,"given":"Alexandra","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Small Animal Specialist Hospital , 1\/1 Richardson Place, North Ryde,Sydney, NSW 2113,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1751-2710","authenticated-orcid":false,"given":"In\u00eas","family":"Freitas","sequence":"additional","affiliation":[{"name":"Stansted Veterinary Specialists , Unit 7 Stansted Courtyard, Bishop's Stortford CM22 6PU ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3851-0631","authenticated-orcid":false,"given":"Daniel","family":"S\u00e1nchez-Masi\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Veterinario Universidad Cat\u00f3lica de Valencia \u201cSan Vicente M\u00e1rtir\u201d , Avenida de P\u00e9rez Gald\u00f3s, 51, 46018 Valencia ,","place":["Spain"]},{"name":"Unavets Veterios Referral Veterinary Hospital , C. 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