{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:25:07Z","timestamp":1787682307864,"version":"build-2784847793"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Research and Innovation Fund","award":["FF-169\/2568"],"award-info":[{"award-number":["FF-169\/2568"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic gingivostomatitis in cats is a debilitating inflammatory disease marked by severe oral pain and systemic immune dysregulation. Although localized oral pathology is well-documented, the systemic peptidomic profile remains largely unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Characterize the serum peptidomic profiles of cats with feline chronic gingivostomatitis (FCGS) and identify systemic biomarkers and signaling hubs that drive disease pathogenesis and therapeutic interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Client-owned cats with clinically and histopathologically confirmed FCGS (n\u00a0=\u00a034) and healthy controls (n\u00a0=\u00a018).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2013control, cross-sectional study was conducted. All cats were screened for feline leukemia virus, feline immunodeficiency virus, and feline heartworm infections. Serum samples were analyzed using matrix-assisted laser desorption\/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) to produce peptide mass fingerprints. Detailed peptide identification was conducted using nanoscale liquid chromatography\u2013tandem mass spectrometry (nano LC\u2013MS\/MS). Functional enrichment and protein\u2013protein\/chemical interaction networks were developed using ShinyGO and the Kyoto Encyclopedia of Genes and Genomes database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both MALDI-TOF MS and nano LC\u2013MS\/MS identified distinct systemic protein signatures that distinguished FCGS from controls. Fifteen proteins showed significant changes, with 13 increased (including inflammatory markers such as interleukin (IL)-6 and interferon-\u03b3) and 2 decreased (gastrin, IL-18). Network analysis identified 8 key proteins (eg, p21(CDKN1A), CASP1, IL-6) that interact with FCGS drug treatments. These systemic changes focus on the Janus kinase\u2013signal transducers and activators of transcription (JAK\u2013STAT) and phosphatidylinositol 3-kinase (PI3K)\/protein kinase B (AKT; PI3K\u2013Akt) pathways, which are important therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Our study provides a molecular framework for FCGS. Whereas MALDI-TOF MS enables rapid systemic profiling, nano LC\u2013MS\/MS identifies key dysregulated pathways, specifically IL-6\/JAK\u2013STAT and PI3K\u2013Akt. These findings offer potential therapeutic targets and a basis for monitoring molecular pathology in affected cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag169","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:53:36Z","timestamp":1787680416000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum peptidomic profiling identifies systemic JAK\u2013STAT and PI3K\u2013Akt pathway dysregulation in cats with chronic gingivostomatitis"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-2565","authenticated-orcid":false,"given":"Sekkarin","family":"Ploypetch","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Public Health, Faculty of Veterinary Science, Mahidol University , Nakorn Pathom 73170 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