{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:37:20Z","timestamp":1787773040701,"version":"build-2784847793"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020696","name":"Research Institute for Veterinary Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020696","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Simethicone enhances visualization quality (VQ) during video capsule endoscopy (VCE) in humans, but its effects on VQ and capsule transit time (CTT) in dogs remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Evaluate the effects of simethicone on VQ and CTT in dogs undergoing VCE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fifteen client-owned healthy dogs weighing 3-10\u00a0kg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, blinded, randomized crossover study. Each dog underwent VCE twice: once with 20\u00a0mg (1\u00a0mL) simethicone administered 30\u00a0minutes before capsule ingestion, and once with 1\u00a0mL normal saline as a control. Visualization quality was assessed based on the proportion of mucosa visualized (variable 1), the degree of obscuration by bubbles, debris, blood, or bile (variable 2), and their average (variable 3). Capsule transit time, including gastric transit time (GTT) and small bowel transit time (SBTT), and incomplete study rates also were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Simethicone significantly improved VQ in the entire small bowel, especially in the proximal segment (P\u00a0&amp;lt;\u00a0.05 for all variables). However, no significant differences were observed between protocols in the distal small bowel and stomach. Gastric transit time and SBTT also were not significantly different between protocols. The risk of incomplete studies was not significantly affected by protocol, sex, body weight, or age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Simethicone had region-specific effects on VQ in dogs undergoing VCE, specifically enhancing VQ in the small intestine. These findings provide preliminary evidence of a potential role for simethicone in improving small bowel VQ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag183","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:15:52Z","timestamp":1787771752000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of simethicone on visualization quality and capsule transit time during video capsule endoscopy in healthy dogs"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-524X","authenticated-orcid":false,"given":"Wooram","family":"Jeong","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University , Seoul 08826 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3255-7049","authenticated-orcid":false,"given":"Gyu-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University , Seoul 08826 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2616-6610","authenticated-orcid":false,"given":"Se-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University , Seoul 08826 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5614-9846","authenticated-orcid":false,"given":"Min-Ok","family":"Ryu","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University , Seoul 08826 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-3278","authenticated-orcid":false,"given":"Kyoung-Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University , Seoul 08826 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026082615154506000_ref1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/jsap.12442","article-title":"Evaluation of capsule endoscopy to detect mucosal lesions associated with gastrointestinal bleeding in dogs","volume":"57","author":"Davignon","year":"2016","journal-title":"J Small Anim Pract"},{"key":"2026082615154506000_ref2","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/jvim.16677","article-title":"Gastrointestinal angiodysplasias diagnosed using video capsule endoscopy in 15 dogs","volume":"37","author":"Defarges","year":"2023","journal-title":"J Vet Intern Med"},{"key":"2026082615154506000_ref3","doi-asserted-by":"publisher","first-page":"926","DOI":"10.2460\/javma.249.8.926","article-title":"Multiple gastric erosions diagnosed by means of capsule endoscopy in a dog","volume":"249","author":"Hardy","year":"2016","journal-title":"J Am Vet Med Assoc"},{"key":"2026082615154506000_ref4","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1111\/jvim.17168","article-title":"Video capsule endoscopy findings in dogs with chronic enteropathy and in healthy dogs","volume":"38","author":"Holmberg","year":"2024","journal-title":"J Vet Intern Med"},{"key":"2026082615154506000_ref5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.12729\/jbtr.2025.26.1.11","article-title":"Clinical approach to chronic enteropathy using capsule endoscopy in two dogs","volume":"26","author":"Jang","year":"2025","journal-title":"J Biomed Transl Res"},{"key":"2026082615154506000_ref6","doi-asserted-by":"publisher","first-page":"e17286","DOI":"10.1111\/jvim.17286","article-title":"Feasibility and complications of videocapsule endoscopy in dogs weighing 7\u2009kg or less","volume":"39","author":"St-Jean","year":"2025","journal-title":"J Vet Intern Med"},{"key":"2026082615154506000_ref7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.12729\/jbtr.2023.24.3.111","article-title":"Clinical application of capsule endoscopy in a dog with acute hemorrhagic vomiting","volume":"24","author":"Bae","year":"2023","journal-title":"J Biomed Transl Res"},{"key":"2026082615154506000_ref8","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1111\/jvim.15584","article-title":"Use of video capsule endoscopy to identify gastrointestinal lesions in dogs with microcytosis or gastrointestinal hemorrhage","volume":"33","author":"Mabry","year":"2019","journal-title":"J Vet Intern Med"},{"key":"2026082615154506000_ref9","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/jsap.13627","article-title":"Assessment of gastrointestinal health in racing Alaskan sled dogs using capsule endoscopy and inflammatory cytokines","volume":"64","author":"Mabry","year":"2023","journal-title":"J Small Anim Pract"},{"key":"2026082615154506000_ref10","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1111\/jvim.16153","article-title":"Feasibility, complications, and quality of visualization using video capsule endoscopy in 40 dogs with overt or questionable gastrointestinal bleeding","volume":"35","author":"Stiller","year":"2021","journal-title":"J Vet Intern Med"},{"key":"2026082615154506000_ref11","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/jsap.13216","article-title":"A pilot study on the effect of fat loading on the gastrointestinal tract of healthy dogs","volume":"61","author":"Palerme","year":"2020","journal-title":"J Small Anim Pract"},{"key":"2026082615154506000_ref12","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1055\/s-0034-1391855","article-title":"Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline","volume":"47","author":"Pennazio","year":"2015","journal-title":"Endoscopy"},{"key":"2026082615154506000_ref13","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1053\/j.gastro.2016.12.032","article-title":"Clinical practice guidelines for the use of video capsule endoscopy","volume":"152","author":"Enns","year":"2017","journal-title":"Gastroenterology"},{"key":"2026082615154506000_ref14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/MEG.0b013e328365b9d4","article-title":"Should bowel preparation, antifoaming agents, or prokinetics be used before video capsule endoscopy? A systematic review and meta-analysis","volume":"26","author":"Kotwal","year":"2014","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2026082615154506000_ref15","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3748\/wjg.v16.i7.875","article-title":"A novel cleansing score system for capsule endoscopy","volume":"16","author":"Park","year":"2010","journal-title":"World J Gastroenterol"},{"key":"2026082615154506000_ref16","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1055\/s-2006-944634","article-title":"The role of simeticone in small-bowel preparation for capsule endoscopy","volume":"38","author":"Ge","year":"2006","journal-title":"Endoscopy"},{"key":"2026082615154506000_ref17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/MCG.0b013e3181f0f3a3","article-title":"Small bowel preparations for capsule endoscopy with mannitol and simethicone: a prospective, randomized, clinical trial","volume":"45","author":"Chen","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"2026082615154506000_ref18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1572-0241.2007.01633.x","article-title":"Purgative bowel cleansing combined with simethicone improves capsule endoscopy imaging","volume":"103","author":"Wei","year":"2008","journal-title":"Am J Gastroenterol ACG"},{"key":"2026082615154506000_ref19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3109\/00365521.2010.525714","article-title":"Systematic review and meta-analysis of randomized controlled trials of simethicone for gastrointestinal endoscopic visibility","volume":"46","author":"Wu","year":"2011","journal-title":"Scand J Gastroenterol"},{"key":"2026082615154506000_ref20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4253\/wjge.v5.i2.67","article-title":"Oral purgative and simethicone before small bowel capsule endoscopy","volume":"5","author":"Rosa","year":"2013","journal-title":"World J Gastrointest Endosc"},{"key":"2026082615154506000_ref21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.ejpb.2019.01.026","article-title":"Characterization of the GI transit conditions in beagle dogs with a telemetric motility capsule","volume":"136","author":"Koziolek","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"key":"2026082615154506000_ref22","doi-asserted-by":"publisher","first-page":"65","DOI":"10.12729\/jbtr.2019.20.3.065","article-title":"A study on the difference of gastrointestinal transit time with minimized capsule endoscope in dogs","volume":"20","author":"Lee","year":"2019","journal-title":"J Biomed Transl Res"},{"key":"2026082615154506000_ref23","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1186\/s13063-021-05527-8","article-title":"Simethicone administration improves gastric cleanness for esophagogastroduodenoscopy: a randomized clinical trial","volume":"22","author":"Sun","year":"2021","journal-title":"Trials"},{"key":"2026082615154506000_ref24","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.gie.2008.06.044","article-title":"Are bowel purgatives and prokinetics useful for small-bowel capsule endoscopy? A prospective randomized controlled study","volume":"69","author":"Postgate","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"2026082615154506000_ref25","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S0016-5107(04)02462-9","article-title":"Complete small-bowel transit in patients undergoing capsule endoscopy: determining factors and improvement with metoclopramide","volume":"61","author":"Selby","year":"2005","journal-title":"Gastrointest Endosc"},{"key":"2026082615154506000_ref26","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.gie.2005.07.043","article-title":"The effect of erythromycin on video capsule endoscopy intestinal-transit time","volume":"63","author":"Caddy","year":"2006","journal-title":"Gastrointest Endosc"},{"key":"2026082615154506000_ref27","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1111\/j.1440-1746.2007.05064.x","article-title":"Effect of mosapride on gastrointestinal transit time and diagnostic yield of capsule endoscopy","volume":"22","author":"Wei","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"2026082615154506000_ref28","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s10620-008-0687-y","article-title":"The effect of metoclopramide in capsule enteroscopy","volume":"55","author":"Almeida","year":"2010","journal-title":"Dig Dis Sci"},{"key":"2026082615154506000_ref29","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.5754\/hge11081","article-title":"Intramuscular injection of metoclopramide decreases the gastric transit time and does not increase the complete examination rate of capsule endoscopy: a prospective randomized controlled trial","volume":"58","author":"Zhang","year":"2011","journal-title":"Hepato-gastroenterology"},{"key":"2026082615154506000_ref30","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/jvim.16057","article-title":"Prevalence of gastrointestinal lesions in dogs chronically treated with nonsteroidal anti-inflammatory drugs","volume":"35","author":"Mabry","year":"2021","journal-title":"J Vet Intern Med"},{"key":"2026082615154506000_ref31","doi-asserted-by":"publisher","first-page":"1440831","DOI":"10.3389\/fvets.2024.1440831","article-title":"Detection of foreign bodies in the canine stomach using capsule endoscopy: a randomized trial","volume":"11","author":"Kim","year":"2024","journal-title":"Front Vet Sci"},{"key":"2026082615154506000_ref32","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2478\/pjvs-2014-0098","article-title":"The effect of macrogol administration on the quality of macroscopic images and transit time in canine capsule endoscopy","volume":"17","author":"Rychlik","year":"2014","journal-title":"Pol J Vet Sci"},{"key":"2026082615154506000_ref33","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/vec.12673","article-title":"The effect of fasting on gastrointestinal motility in healthy dogs as assessed by sonography","volume":"27","author":"Sanderson","year":"2017","journal-title":"J Vet Emerg Crit Care (San Antonio)"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/40\/4\/aalag183\/70808904\/aalag183.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/40\/4\/aalag183\/70808904\/aalag183.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:15:53Z","timestamp":1787771753000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/doi\/10.1093\/jvimsj\/aalag183\/8771359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jvimsj\/aalag183","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7,1]]},"article-number":"aalag183"}}