{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:09:11Z","timestamp":1788739751823,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low testosterone concentrations are associated with poor lung function in human asthmatics, and androgen administration improves airway obstruction in women with asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Testosterone improves clinical scores, lung function, airway neutrophilia, and airway remodeling in horses with severe asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ten horses affected by severe asthma from a research herd.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a randomized, blinded, crossover study, horses received dexamethasone (0.06\u00a0mg\/kg PO q24h for 10\u00a0days) or a single intramuscular injection of testosterone cypionate (0.35\u00a0mg\/kg), with a 2-week washout period. Clinical respiratory scores were assessed at days 0, 2, 5, and 10; lung function was evaluated at days 0, 5, and 10; and bronchoalveolar lavage fluid cytology and central airway remodeling at days 0 and 10. Mixed linear models were used for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The respiratory clinical scores improved with dexamethasone administration (median [95% CI], from 12 (9-13) to 5 (3-6), P\u00a0&amp;lt;\u00a0.001), and remained unchanged with testosterone administration (from 10 [8-12] to 9 [8-11], P\u00a0=\u00a0.6). Pulmonary elastance improved with both treatments, but the effect was more pronounced with dexamethasone administration (from 5.1\u00a0cm H2O\/L [2.4-5.8] to 0.5 [0.4-0.8], P\u00a0&amp;lt;\u00a0.001) than with testosterone administration (from 4.5\u00a0cm H2O\/L [1.6-8.5] to 3.0 [1.0-4.1], P\u00a0=\u00a0.04). Pleural pressure and pulmonary resistance decreased only with dexamethasone. Neither treatment altered airway neutrophilia or bronchial remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Testosterone is less effective than dexamethasone and only mildly improves pulmonary elastance in horses with severe asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag187","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:02:04Z","timestamp":1788739324000},"source":"Crossref","is-referenced-by-count":0,"title":["Randomized study of the effects of testosterone administration on severity of asthma in horses"],"prefix":"10.1093","volume":"40","author":[{"given":"Camille","family":"Ruault","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Quebec 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