{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:45Z","timestamp":1792786005258,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["RS-2025-24683314"],"award-info":[{"award-number":["RS-2025-24683314"]}]},{"name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry"},{"name":"Agriculture and Food Convergence Technologies Program for Research Manpower Development","id":[{"id":"https:\/\/ror.org\/03n17ds51","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Agriculture, Food, and Rural Affairs","award":["RS-2024-00398561"],"award-info":[{"award-number":["RS-2024-00398561"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have evaluated the association between myxomatous mitral valve disease (MMVD) and pancreatic lipase activity, but medications remain unconsidered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Elevated serum pancreatic lipase activity is related to cardiac medication in dogs with MMVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eighty-two client-owned dogs without clinical signs of pancreatitis (MMVD, n\u00a0=\u00a067 [stage B1\u00a0=\u00a024; stage B2\u00a0=\u00a022; non-medicated stage C\u00a0=\u00a09; medicated stage C\u00a0=\u00a012]; controls, n\u00a0=\u00a015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cross-sectional study. Dogs were classified into MMVD stage and control groups. Serum pancreatic lipase activity was compared among groups, and correlation and multivariable linear regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In non-medicated dogs, pancreatic lipase activity did not differ among groups. In contrast, medicated stage C dogs had higher pancreatic lipase activity than controls (median difference, 67.5\u00a0U\/L; 95% CI, 19.0-184.0), stage B1 (57.0\u00a0U\/L; 95% CI, 12.0-145.0), stage B2 (65.8\u00a0U\/L; 95% CI, 18.0-156.0), and non-medicated stage C (58.0\u00a0U\/L; 95% CI, 9.0-268.0). Moreover, 25% (3\/12) of medicated stage C dogs had pancreatic lipase activity exceeding 400\u00a0U\/L, whereas no non-medicated stage C dogs reached this threshold. Pancreatic lipase activity was positively correlated with furosemide (\u03c1\u00a0=\u00a00.67) and duration of angiotensin-converting enzyme inhibitor (\u03c1\u00a0=\u00a00.62) administration. In multivariable analysis, medication was the independent predictor of pancreatic lipase activity in dogs with MMVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>Pancreatic lipase activity might be elevated in some dogs with MMVD receiving cardiac medications, highlighting the importance of considering medication history in clinical interpretation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract (Korean)<\/jats:title>\n                    <jats:p>\ubc30\uacbd: \uae30\uc874 \uc5f0\uad6c\uc5d0\uc11c \uac1c\uc758 \uc810\uc561\uc885\uc131 \uc2b9\ubaa8\ud310\ub9c9\uc9c8\ubcd1(myxomatous mitral valve disease, MMVD)\uacfc \ud608\uccad \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\uc758 \uc5f0\uad00\uc131\uc774 \ud3c9\uac00\ub418\uc5c8\uc73c\ub098, \uc2ec\uc7a5\uc57d\ubb3c\uc774 \ud608\uccad \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc740 \uace0\ub824\ub418\uc9c0 \uc54a\uc558\ub2e4. \uac00\uc124: MMVD\uc5d0 \uc774\ud658\ub41c \uac1c\uc5d0\uc11c \ud608\uccad \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\uc758 \uc99d\uac00\ub294 \uc2ec\uc7a5\uc57d\ubb3c \ud22c\uc5ec\uc640 \uad00\ub828\uc774 \uc788\uc744 \uac83\uc774\ub2e4. \uc5f0\uad6c\ub300\uc0c1: \ucdcc\uc7a5\uc5fc\uc758 \uc784\uc0c1\uc99d\uc0c1\uc774 \uc5c6\ub294 \uac1c 82\ub9c8\ub9ac\ub97c \ub300\uc0c1\uc73c\ub85c \ud558\uc600\ub2e4(MMVD 67\ub9c8\ub9ac [Stage B1\u00a0=\u00a024\ub9c8\ub9ac, Stage B2\u00a0=\u00a022\ub9c8\ub9ac, \uc2ec\uc7a5\uc57d\ubb3c\uc744 \ud22c\uc5ec \ubc1b\uc9c0 \uc54a\uc740 Stage C\u00a0=\u00a09\ub9c8\ub9ac, \uc2ec\uc7a5\uc57d\ubb3c\uc744 \ud22c\uc5ec \ubc1b\uc740 Stage C\u00a0=\u00a012\ub9c8\ub9ac]\uc640 \ub300\uc870\uad70 15\ub9c8\ub9ac). \uc5f0\uad6c\ubc29\ubc95: \ud6c4\ud5a5\uc801 \ub2e8\uba74\uc5f0\uad6c\ub97c \uc218\ud589\ud558\uc600\ub2e4. \uc5f0\uad6c\ub300\uc0c1 \uac1c\ub97c MMVD \ub2e8\uacc4 \ubc0f \ub300\uc870\uad70\uc73c\ub85c \ubd84\ub958\ud558\uc600\ub2e4. \uadf8\ub8f9 \uac04 \ud608\uccad \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\ub97c \ube44\uad50\ud558\uc600\uc73c\uba70, \uc0c1\uad00\ubd84\uc11d\uacfc \ub2e4\ubcc0\ub7c9 \uc120\ud615\ud68c\uadc0\ubd84\uc11d\uc744 \uc218\ud589\ud558\uc600\ub2e4. \uacb0\uacfc: \uc2ec\uc7a5\uc57d\ubb3c\uc744 \ud22c\uc5ec \ubc1b\uc9c0 \uc54a\uc740 \uac1c\uc5d0\uc11c\ub294 \uadf8\ub8f9 \uac04 \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\uc5d0 \uc720\uc758\ud55c \ucc28\uc774\uac00 \uc5c6\uc5c8\ub2e4. \ubc18\uba74, \uc2ec\uc7a5\uc57d\ubb3c\uc744 \ud22c\uc5ec \ubc1b\uc740 Stage C \uac1c\uc5d0\uc11c\ub294 \ub300\uc870\uad70(\uc911\uc559\uac12 \ucc28\uc774 67.5\u00a0U\/L; 95% \uc2e0\ub8b0\uad6c\uac04 [CI], 19.0-184.0), Stage B1(57.0\u00a0U\/L; 95% CI, 12.0-145.0), Stage B2(65.8\u00a0U\/L; 95% CI, 18.0-156.0) \ubc0f \uc2ec\uc7a5\uc57d\ubb3c\uc744 \ud22c\uc5ec \ubc1b\uc9c0 \uc54a\uc740 Stage C(58.0\u00a0U\/L; 95% CI, 9.0-268.0)\uc5d0 \ube44\ud574 \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\uac00 \ub192\uc558\ub2e4. \ub610\ud55c \uc2ec\uc7a5\uc57d\ubb3c\uc744 \ud22c\uc5ec \ubc1b\uc740 Stage C \uac1c\uc758 25%(3\/12)\uc5d0\uc11c \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\uac00 400\u00a0U\/L\ub97c \ucd08\uacfc\ud55c \ubc18\uba74, \uc2ec\uc7a5\uc57d\ubb3c\uc744 \ud22c\uc5ec \ubc1b\uc9c0 \uc54a\uc740 Stage C \uac1c\uc5d0\uc11c\ub294 400\u00a0U\/L\ub97c \ucd08\uacfc\ud55c \uac1c\uac00 \uc5c6\uc5c8\ub2e4. \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\ub294 \ud478\ub85c\uc138\ub9c8\uc774\ub4dc \ud22c\uc5ec\uae30\uac04(\u03c1\u00a0=\u00a00.67) \ubc0f \uc548\uc9c0\uc624\ud150\uc2e0-\uc804\ud658 \ud6a8\uc18c \uc5b5\uc81c\uc81c \ud22c\uc5ec\uae30\uac04(\u03c1\u00a0=\u00a00.62)\uacfc \uc591\uc758 \uc0c1\uad00\uad00\uacc4\ub97c \ubcf4\uc600\ub2e4. \ub2e4\ubcc0\ub7c9 \ubd84\uc11d\uc5d0\uc11c \uc2ec\uc7a5\uc57d\ubb3c \ud22c\uc5ec\ub294 MMVD \uac1c\uc758 \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\uc640 \ub3c5\ub9bd\uc801 \uc5f0\uad00 \uc694\uc778\uc774\uc5c8\ub2e4. \uacb0\ub860 \ubc0f \uc784\uc0c1\uc801 \uc758\uc758: \uc2ec\uc7a5\uc57d\ubb3c\uc744 \ud22c\uc5ec \ubc1b\ub294 \uc77c\ubd80 MMVD \uac1c\uc5d0\uc11c \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \ud65c\uc131\ub3c4\uac00 \uc99d\uac00\ud560 \uc218 \uc788\uc73c \ubbc0\ub85c, MMVD \uac1c\uc5d0\uc11c \ucdcc\uc7a5 \ub77c\uc774\ud398\uc774\uc2a4 \uac80\uc0ac \uacb0\uacfc \ud574\uc11d \uc2dc \uc2ec\uc7a5\uc57d\ubb3c \ud22c\uc5ec \uc774\ub825\uc744 \ud568\uaed8 \uace0\ub824\ud574\uc57c \ud55c\ub2e4.<\/jats:p>\n                  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