{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:51:04Z","timestamp":1791442264085,"version":"4.3.3"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["#RGPIN\/4514-2018"],"award-info":[{"award-number":["#RGPIN\/4514-2018"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Equine Guelph"},{"name":"TTUSVM Start-up fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alterations in intestinal microbiota composition, as determined by DNA sequencing, are reported in horses with acute colitis compared with healthy horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Changes in specific bacterial populations can detect overall intestinal disruption of the normal intestinal microbiota. Identify bacterial taxa that indicate intestinal dysbiosis or health in horses using quantitative PCR (qPCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty horses with undifferentiated colitis, 13 with colitis associated with Salmonella spp., 14 with antibiotic-associated diarrhea (AAD), 52 healthy horses from Canada and 48 from the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective multicenter cross-sectional study. Horses were included in this study through a search of medical records of acute colitis cases, for which a fecal sample was collected. qPCR assays were developed for 14 bacterial taxa and compared using Welch t-test, one-way Analysis of Variance (ANOVA), Kruskal-Wallis or Welch\u2019s ANOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>qPCR analysis showed significant differences in absolute abundance in 7 out of the 14 bacterial taxa tested. Differences that were consistent across all colitis groups included higher abundance of Enterobacteriaceae (mean log10DNA\u00a0\u00b1\u00a0SD; Control_Canada: 2.51\u00a0\u00b1\u00a00.53 vs undifferentiated: 3.43\u00a0\u00b1\u00a01.00; Control_USA: 2.06\u00a0\u00b1\u00a00.91 vs Salmonella spp.: 3.65\u00a0\u00b1\u00a01.05 and AAD: 4.22\u00a0\u00b1\u00a00.97, all P\u00a0&amp;lt;\u00a0.01) and Escherichia coli (2.28\u00a0\u00b1\u00a01.13 vs 3.54\u00a0\u00b1\u00a01.54; 1.80\u00a0\u00b1\u00a01.25 vs 3.74\u00a0\u00b1\u00a01.30 and 3.90\u00a0\u00b1\u00a01.52, all P\u00a0&amp;lt;\u00a0.01) and lower abundance of Turicibacter spp. (4.10\u00a0\u00b1\u00a00.24 vs 3.86\u00a0\u00b1\u00a00.37; 3.64\u00a0\u00b1\u00a00.27 vs 3.17\u00a0\u00b1\u00a00.30 and 2.96\u00a0\u00b1\u00a00.60, respectively; all P\u00a0&amp;lt;\u00a0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>This study reports changes in bacterial taxa across various colitis phenotypes and indicates that this approach could serve as a faster, cost-effective proxy for detecting dysbiosis in the gastrointestinal tract of horses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag231","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:35:14Z","timestamp":1791394514000},"source":"Crossref","is-referenced-by-count":0,"title":["Quantitative assessment of specific bacterial taxa of the intestinal microbiota of healthy and diarrheic horses"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0552-6591","authenticated-orcid":false,"given":"Laurie","family":"Boucher","sequence":"first","affiliation":[{"name":"Department of Veterinary Biomedical Sciences, Faculty of Veterinary Medicine, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Quebec J2S 2M2 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Clinical Sciences, Faculty of Veterinary Medicine, Universit\u00e9 de Montr\u00e9al , St-Hyacinthe J2S 2M2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-6932","authenticated-orcid":false,"given":"Jan S","family":"Suchodolski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences , Texas A&M University, College Station, Texas 77845,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-2609","authenticated-orcid":false,"given":"Rachel","family":"Pilla","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University , College Station, Texas 77845 ,","place":["United 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