{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:50:21Z","timestamp":1791654621509,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dilated cardiomyopathy (DCM) in Doberman Pinschers (DPs) often initially manifests as ventricular arrhythmias (stage B1) without echocardiographic evidence of cardiac remodeling (stage B2). Global longitudinal strain (GLS) is a sensitive echocardiographic variable for detecting early systolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To assess whether GLS detects systolic dysfunction in DPs with arrhythmogenic stage B1 and to evaluate the association between arrhythmic burden and GLS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-three DPs with arrhythmogenic stage B1 DCM and 63 control DPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case\u2013control study. Stage B1 was defined as \u2265300 ventricular premature complexes (VPCs) within 24\u00a0h or &amp;gt;50 VPCs on two 24-h Holter recordings within 1\u00a0year, with otherwise normal echocardiographic measurements. Forty-three dogs had \u201clast-normal\u201d (LN) examinations 6-12\u00a0months before arrhythmia onset. GLS was measured using 2-dimensional speckle-tracking echocardiography (STE) from left apical 2-, 3-, and 4-chamber views. Stage B1 dogs were subclassified into low-grade (LGvpc) and high-grade (HGvpc) groups based on arrhythmic burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GLS was lower in stage B1 dogs (mean\u00a0\u00b1\u00a0SD, \u221216.80%\u00a0\u00b1\u00a02.71%) compared to controls (\u221220.22%\u00a0\u00b1\u00a01.90%; P\u00a0=\u00a0.044). Stage B1 dogs had lower GLS compared to their LN examinations (mean difference, \u22122.45%; 95% CI, \u22123.67% to \u22121.24%; P\u00a0&amp;lt;\u00a0.001). Dogs in the HGvpc group had lower GLS (\u221215.45%\u00a0\u00b1\u00a02.79%) than LGvpc dogs (\u221218.39%\u00a0\u00b1\u00a01.51%; mean difference, \u22122.94%; 95% CI, \u22124.28% to \u22121.60%; P\u00a0&amp;lt;\u00a0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLS detects systolic dysfunction in DPs with arrhythmogenic stage B1 DCM despite normal conventional echocardiographic measurements. Higher arrhythmic burden is associated with more severe systolic dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag242","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:39:08Z","timestamp":1791653948000},"source":"Crossref","is-referenced-by-count":0,"title":["Global longitudinal strain assessment of systolic dysfunction in Doberman Pinschers with ventricular arrhythmias and normal echocardiographic measurements"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2464-2876","authenticated-orcid":false,"given":"Katharina","family":"Hofmeister","sequence":"first","affiliation":[{"name":"Small Animal Clinic of the LMU, LMU University , Munich 80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1540-8127","authenticated-orcid":false,"given":"Jana","family":"Friederich","sequence":"additional","affiliation":[{"name":"Small Animal Clinic of the LMU, LMU University , Munich 80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5493-3708","authenticated-orcid":false,"given":"Jessica","family":"Sch\u00f6bel","sequence":"additional","affiliation":[{"name":"Small Animal Clinic of the LMU, LMU University , Munich 80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3152-6159","authenticated-orcid":false,"given":"Sabine","family":"Hertzsch","sequence":"additional","affiliation":[{"name":"Small Animal Clinic of the LMU, LMU University , Munich 80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-9976","authenticated-orcid":false,"given":"Jenny","family":"Eberhard","sequence":"additional","affiliation":[{"name":"Small Animal Clinic of the LMU, LMU University , Munich 80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3385-8449","authenticated-orcid":false,"given":"Robin","family":"Sch\u00fcttpelz","sequence":"additional","affiliation":[{"name":"Statistical Consulting Unit StaBLab, LMU University , Munich 80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-8072","authenticated-orcid":false,"given":"Gerhard","family":"Wess","sequence":"additional","affiliation":[{"name":"Small Animal Clinic of the LMU, LMU University , Munich 80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"2026101013390098100_ref1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1053\/tvjl.2001.0571","article-title":"Canine idiopathic dilated cardiomyopathy. 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