{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:50:52Z","timestamp":1791654652146,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IVC Evidensia Research Fund","id":[{"id":"https:\/\/ror.org\/002cx2f43","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 4-month-old female-intact German Shepherd mixed breed dog was evaluated for polyuria, polydipsia, oral discomfort, tachypnea, and pyrexia. Blood testing documented total and ionized hypercalcemia with an increased parathyroid hormone concentration. Computed tomography identified bone abnormalities of the mandibule and mild, diffuse pulmonary changes. Ultrasonography of the neck documented one mildly enlarged parathyroid gland that was surgically removed. Histopathology indicated diffuse chief cell hyperplasia. The ionized calcium concentration normalized within 7 days postoperatively.<\/jats:p>","DOI":"10.1093\/jvimsj\/aalag247","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:39:07Z","timestamp":1791653947000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary hyperparathyroidism in a 4-month-old German Shepherd mixed breed dog"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9858-891X","authenticated-orcid":false,"given":"Juan","family":"Aires-Serrano","sequence":"first","affiliation":[{"name":"Pride Veterinary Referrals, Surgery Department , Derby DE24 8HJ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Shimali","sequence":"additional","affiliation":[{"name":"Oakwood Veterinary Referrals, Internal Medicine Department , Hartford CW8 1LP ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Renard","sequence":"additional","affiliation":[{"name":"Vet Oracle Teleradiology , Norfolk IP22 4ER ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-2148","authenticated-orcid":false,"given":"Frances","family":"Bird","sequence":"additional","affiliation":[{"name":"Pride Veterinary Referrals, Surgery Department , Derby DE24 8HJ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-8902","authenticated-orcid":false,"given":"Alenka","family":"Hrovat","sequence":"additional","affiliation":[{"name":"Oakwood Veterinary Referrals, Internal Medicine Department , Hartford CW8 1LP ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"2026101013390101600_ref1","doi-asserted-by":"publisher","first-page":"350","DOI":"10.2460\/javma.1987.191.03.350","article-title":"Primary hyperparathyroidism in dogs: 21 cases (1976\u20131986)","volume":"191","author":"Berger","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"2026101013390101600_ref2","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.2460\/javma.1993.202.07.1132","article-title":"Primary parathyroid gland hyperplasia in dogs: six cases (1982-1991)","volume":"202","author":"DeVries","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"2026101013390101600_ref3","doi-asserted-by":"publisher","first-page":"756","DOI":"10.2460\/javma.2005.227.756","article-title":"Pretreatment clinical and laboratory findings in dogs with primary hyperparathyroidism: 210 cases (1987\u20132004)","volume":"227","author":"Feldman","year":"2005","journal-title":"J Am Vet Med Assoc"},{"key":"2026101013390101600_ref4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1748-5827.2005.tb00268.x","article-title":"Primary hyperparathyroidism in 29 dogs: diagnosis, treatment, outcome and associated renal failure","volume":"46","author":"Gear","year":"2005","journal-title":"J Small Anim Pract"},{"key":"2026101013390101600_ref5","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1111\/vru.12789","article-title":"Ultrasonographic size of the canine parathyroid gland may not correlate with histopathology","volume":"60","author":"Secrest","year":"2019","journal-title":"Vet Radiol Ultrasound"},{"key":"2026101013390101600_ref6","volume-title":"Textbook of Veterinary Internal Medicine: Diseases of the Dog and the Cat","author":"Ettinger","year":"2024"},{"key":"2026101013390101600_ref7","volume-title":"BSAVA Congress Proceedings 2023","author":"Piazza","year":"2023"},{"key":"2026101013390101600_ref8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/vru.12451","article-title":"Analysis of factors affecting outcome of ultrasound-guided radiofrequency heat ablation for treatment of primary hyperparathyroidism in dogs","volume":"58","author":"Bucy","year":"2017","journal-title":"Vet Radiol Ultrasound"},{"key":"2026101013390101600_ref9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2460\/javma.247.7.771","article-title":"Outcomes for dogs with primary hyperparathyroidism following treatment with percutaneous ultrasound-guided ethanol ablation of presumed functional parathyroid nodules: 27 cases (2008-2011)","volume":"247","author":"Guttin","year":"2015","journal-title":"JAVMA."},{"key":"2026101013390101600_ref10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.5326\/0430070","article-title":"Retrospective evaluation of three treatment methods for primary hyperparathyroidism in dogs","volume":"43","author":"Rasor","year":"2007","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026101013390101600_ref11","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1136\/vr.105563","article-title":"Prevalence of canine primary hyperparathyroidism recurrence in Keeshond and non-Keeshond dogs after curative parathyroidectomy","volume":"187","author":"Thompson","year":"2020","journal-title":"Vet Rec"},{"key":"2026101013390101600_ref12","doi-asserted-by":"publisher","first-page":"e70056","DOI":"10.1111\/age.70056","article-title":"Autosomal dominant primary hyperparathyroidism in the Keeshond dog breed is strongly associated with a missense variant in sirtuin-6","volume":"56","author":"Wade","year":"2025","journal-title":"Anim Genet"},{"key":"2026101013390101600_ref13","doi-asserted-by":"publisher","first-page":"5539349","DOI":"10.1155\/2021\/5539349","article-title":"Primary hyperparathyroidism (PHPT) in children: two case reports and review of the literature","volume":"2021","author":"Tuli","year":"2021","journal-title":"Case Rep Endocrinol"},{"key":"2026101013390101600_ref14","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s12098-009-0289-5","article-title":"Primary hyperparathyroidism in children and adolescents","volume":"77","author":"George","year":"2010","journal-title":"Indian J Pediatr"},{"key":"2026101013390101600_ref15","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000112592","article-title":"Primary hyperparathyroidism in neonates and childhood","volume":"69","author":"Mallet","year":"2008","journal-title":"Horm Res Paediatr"},{"key":"2026101013390101600_ref16","doi-asserted-by":"publisher","first-page":"e1749","DOI":"10.1210\/clinem\/dgad267","article-title":"Incidence of primary hyperparathyroidism in the current era: have we finally reached a steady state?","volume":"108","author":"Wermers","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"2026101013390101600_ref17","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1177\/030098588402100402","article-title":"Primary hyperparathyroidism in German shepherd dogs: a disorder of probable genetic origin","volume":"21","author":"Thompson","year":"1984","journal-title":"Vet Pathol"},{"key":"2026101013390101600_ref18","first-page":"909","article-title":"Canine carpal conundrums","volume":"51","author":"Harasen","year":"2010","journal-title":"Can Vet J"},{"key":"2026101013390101600_ref19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cvsm.2019.10.007","article-title":"Bacterial pneumonia in dogs and cats","volume":"50","author":"Dear","year":"2020","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"key":"2026101013390101600_ref20","volume-title":"Small Animal Pediatrics","author":"Mattoon","year":"2011:169-191"},{"key":"2026101013390101600_ref21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/B978-1-4377-0654-3.00013-5","volume-title":"Fluid, Electrolyte, and Acid-Base Disorders in Small Animal Practice","author":"Schenck","year":"2012"},{"key":"2026101013390101600_ref22","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/vec.12162","article-title":"Reference intervals and age-related changes for venous biochemical, hematological, electrolytic, and blood gas variables using a point of care analyzer in 68 puppies","volume":"24","author":"O\u2019Brien","year":"2014","journal-title":"J Vet Emerg Crit Care"},{"key":"2026101013390101600_ref23","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.cvsm.2013.10.003","article-title":"Pediatric clinical pathology","volume":"44","author":"Dehn","year":"2014","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026101013390101600_ref24","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1007\/s00247-023-05702-w","article-title":"Can we skip technetium-99 m sestamibi scintigraphy in pediatric primary hyperparathyroidism patients with positive neck ultrasound results?","volume":"53","author":"He","year":"2023","journal-title":"Pediatr Radiol"},{"key":"2026101013390101600_ref25","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.cvsm.2021.12.004","article-title":"Current concepts in parathyroid\/thyroid surgery","volume":"52","author":"Townsend","year":"2022","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026101013390101600_ref26","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/j.1532-950X.2008.00457.x","article-title":"Validation of a rapid parathyroid hormone assay and intraoperative measurement of parathyroid hormone in dogs with benign naturally occurring primary hyperparathyroidism","volume":"38","author":"Ham","year":"2009","journal-title":"Vet Surg"},{"key":"2026101013390101600_ref27","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jpedsurg.2016.01.018","article-title":"Outcomes of minimally invasive parathyroidectomy in pediatric patients with primary hyperparathyroidism owing to parathyroid adenoma: a single institution experience","volume":"52","author":"Mancilla","year":"2017","journal-title":"J Pediatr Surg"},{"key":"2026101013390101600_ref28","doi-asserted-by":"publisher","first-page":"E347","DOI":"10.1210\/jc.2010-1723","article-title":"Rapid correction of bone mass after parathyroidectomy in an adolescent with primary hyperparathyroidism","volume":"96","author":"Vanstone","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2026101013390101600_ref29","doi-asserted-by":"publisher","first-page":"2390925","DOI":"10.1155\/crpe\/2390925","article-title":"Long-term consequences of misdiagnosis of parathyroid adenomas in pediatric patients","volume":"2025","author":"Roztoczy\u0144ska","year":"2025","journal-title":"Case Rep Pediatr"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/40\/5\/aalag247\/71838269\/aalag247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/40\/5\/aalag247\/71838269\/aalag247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:39:09Z","timestamp":1791653949000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/doi\/10.1093\/jvimsj\/aalag247\/8907319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jvimsj\/aalag247","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,9,1]]},"article-number":"aalag247"}}