{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:51:17Z","timestamp":1791597077589,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Viscoelastic testing provides whole-blood assessment of coagulation, but clinical data on the performance of the ClotPro in dogs with naturally occurring diseases are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To evaluate pathway coherence of ClotPro variables with routine coagulation tests and to explore disease-associated viscoelastic phenotypes, fibrinolysis, and hypercoagulability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eighty-four client-owned dogs admitted to a university hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study. ClotPro variables (clotting time, amplitude at 10\u00a0min, maximum clot firmness, maximum lysis across extrinsic pathway test [EX], intrinsic pathway test [IN], fibrinogen test channel, aprotinin test [AP] channels) were compared with prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet count (PLT), and D-dimer using Spearman correlation with Benjamini\u2013Hochberg adjustment. Group differences were assessed with Kruskal\u2013Wallis and Dunn\u2019s post hoc. Hyperfibrinolysis (HF) was defined using paired EX\u2013AP. A hypercoagulability index (HCI) and platelet\/fibrin-adjusted residual firmness were derived.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PT correlated with clotting time in EX channel (\u03c1\u00a0=\u00a00.48, q\u00a0=\u00a00.002) and aPTT with clotting time in IN channel (\u03c1\u00a0=\u00a00.42, q\u00a0=\u00a00.007). PLT correlated with maximum clot firmness in EX channel (EX_MCF) (\u03c1\u00a0=\u00a00.50, q\u00a0=\u00a00.001). maximum clot firmness in FIB channel correlated with EX_MCF (\u03c1\u00a0=\u00a00.58, q\u00a0&amp;lt;\u00a00.001) and maximum clot firmness in IN channel (\u03c1\u00a0=\u00a00.47, q\u00a0=\u00a00.003). maximum lysis in EX channel (EX_ML) correlated inversely with EX_MCF (\u03c1\u00a0=\u00a0\u22120.35, q\u00a0=\u00a00.028). D-dimer correlated with EX_ML (\u03c1\u00a0=\u00a00.30, q\u00a0=\u00a00.049). Group-level distributions overlapped substantially. HF was infrequent among cases (33% in dogs with hepatopathy and 21% in dogs with hemorrhagic diarrhea). The HCI differed across diseases (P\u00a0=\u00a0.0002), whereas platelet\/fibrin-adjusted residual firmness did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical importance<\/jats:title>\n                    <jats:p>ClotPro variables demonstrated pathway-specific coherence with routine coagulation testing and consistent fibrinolysis patterns. Disease states did not define discrete viscoelastic phenotypes, supporting case-level interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jvimsj\/aalag254","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:32:00Z","timestamp":1791595920000},"source":"Crossref","is-referenced-by-count":0,"title":["ClotPro viscoelastic testing in coagulation disorders in dogs: a retrospective analysis"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8731-2936","authenticated-orcid":false,"given":"Pavlos G","family":"Doulidis","sequence":"first","affiliation":[{"name":"Clinical Unit of Small Animal Internal Medicine, Department for Companion Animals and Horses, University of Veterinary Medicine , 1210 Vienna 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