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In Arabidopsis thaliana, Fe starvation limits infection by necrotrophic pathogens. Here, we report that Fe deficiency also reduces disease caused by the hemi-biotrophic bacterium Pseudomonas syringae and the biotrophic oomycete Hyaloperonospora arabidopsidis, indicating that Fe deficiency-induced resistance is effective against pathogens with different lifestyles. Furthermore, we show that Fe deficiency-induced resistance is not caused by withholding Fe from the pathogen but is a plant-mediated defense response that requires activity of ethylene and salicylic acid. Because rhizobacteria-induced systemic resistance (ISR) is associated with a transient up-regulation of the Fe deficiency response, we tested whether Fe deficiency-induced resistance and ISR are similarly regulated. However, Fe deficiency-induced resistance functions independently of the ISR regulators MYB72 and BGLU42, indicating that both types of induced resistance are regulated in a different manner. Mutants opt3 and frd1, which display misregulated Fe homeostasis under Fe-sufficient conditions, show disease resistance levels comparable with those of Fe-starved wild-type plants. Our results suggest that disturbance of Fe homeostasis, through Fe starvation stress or other non-homeostatic conditions, is sufficient to prime the plant immune system for enhanced defense.<\/jats:p>","DOI":"10.1093\/jxb\/eraa535","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T20:56:55Z","timestamp":1605041815000},"page":"2231-2241","source":"Crossref","is-referenced-by-count":48,"title":["Mechanisms underlying iron deficiency-induced resistance against pathogens with different lifestyles"],"prefix":"10.1093","volume":"72","author":[{"given":"Pauline L","family":"Trapet","sequence":"first","affiliation":[{"name":"Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, Padualaan, CH Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline H","family":"Verbon","sequence":"additional","affiliation":[{"name":"Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, Padualaan, CH Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renda R","family":"Bosma","sequence":"additional","affiliation":[{"name":"Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, Padualaan, CH Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Voordendag","sequence":"additional","affiliation":[{"name":"Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, Padualaan, CH Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan A","family":"Van Pelt","sequence":"additional","affiliation":[{"name":"Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, Padualaan, CH Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-4646","authenticated-orcid":false,"given":"Corn\u00e9 M J","family":"Pieterse","sequence":"additional","affiliation":[{"name":"Plant-Microbe Interactions, Department of Biology, Science4Life, Utrecht University, Padualaan, CH Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,14]]},"reference":[{"key":"2021031707393801600_CIT0001","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.plantsci.2015.08.022","article-title":"Immunity to plant pathogens and iron homeostasis","volume":"240","author":"Aznar","year":"2015","journal-title":"Plant Science"},{"key":"2021031707393801600_CIT0002","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/mpp.12208","article-title":"Alterations of iron distribution in Arabidopsis tissues infected by Dickeya 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