{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:46:27Z","timestamp":1792154787207,"version":"4.4.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02115"],"award-info":[{"award-number":["18H02115"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJCR15O2"],"award-info":[{"award-number":["JPMJCR15O2"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Under low iron (Fe) availability, plants transcriptionally induce various genes responsible for Fe uptake and translocation to obtain adequate amounts of Fe. Although transcription factors and ubiquitin ligases involved in these Fe deficiency responses have been identified, the mechanisms coordinating these pathways have not been clarified in rice. Recently identified Fe-deficiency-inducible IRON MAN (IMA)\/FE UPTAKE-INDUCING PEPTIDE (FEP) positively regulates many Fe-deficiency-inducible genes for Fe uptake in Arabidopsis. Here, we report that the expression of two IMA\/FEP genes in rice, OsIMA1 and OsIMA2, is strongly induced under Fe deficiency, positively regulated by the transcription factors IDEF1, OsbHLH058, and OsbHLH059, as well as OsIMA1 and OsIMA2 themselves, and negatively regulated by HRZ ubiquitin ligases. Overexpression of OsIMA1 or OsIMA2 in rice conferred tolerance to Fe deficiency and accumulation of Fe in leaves and seeds. These OsIMA-overexpressing rice exhibited enhanced expression of all of the known Fe-deficiency-inducible genes involved in Fe uptake and translocation, except for OsYSL2, a Fe\u2013nicotianamine transporter gene, in roots but not in leaves. Knockdown of OsIMA1 or OsIMA2 caused minor effects, including repression of some Fe uptake- and translocation-related genes in OsIMA1 knockdown roots. These results indicate that OsIMA1 and OsIMA2 play key roles in enhancing the major pathway of the Fe deficiency response in rice.<\/jats:p>","DOI":"10.1093\/jxb\/eraa546","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T23:21:39Z","timestamp":1605223299000},"page":"2196-2211","source":"Crossref","is-referenced-by-count":83,"title":["Iron deficiency-inducible peptide-coding genes\n                    <i>OsIMA1<\/i>\n                    and\n                    <i>OsIMA2<\/i>\n                    positively regulate a major pathway of iron uptake and translocation in rice"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-6955","authenticated-orcid":false,"given":"Takanori","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University , Suematsu, Nonoichi, Ishikawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi J","family":"Nagano","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Ryukoku University , Otsu, Shiga ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko K","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University , Suematsu, Nonoichi, Ishikawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"2026041420070474900_CIT0001","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/ppl.12698","article-title":"Rice HRZ ubiquitin ligases are crucial for response to excess iron","volume":"163","author":"Aung","year":"2018","journal-title":"Physiologia Plantarum"},{"key":"2026041420070474900_CIT0002","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3389\/fpls.2019.00660","article-title":"Nicotianamine synthesis by OsNAS3 is important for mitigating iron excess stress in rice","volume":"10","author":"Aung","year":"2019","journal-title":"Frontiers in Plant Science"},{"key":"2026041420070474900_CIT0003","doi-asserted-by":"crossref","first-page":"32395","DOI":"10.1074\/jbc.M604133200","article-title":"Cloning and characterization of deoxymugineic acid synthase genes from graminaceous plants","volume":"281","author":"Bashir","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"2026041420070474900_CIT0004","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11103-015-0315-0","article-title":"Iron deficiency regulated OsOPT7 is essential for iron homeostasis in rice","volume":"88","author":"Bashir","year":"2015","journal-title":"Plant Molecular Biology"},{"key":"2026041420070474900_CIT0005","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/aob\/mcp128","article-title":"New insights into ferritin synthesis and function highlight a link between iron homeostasis and oxidative stress in plants","volume":"105","author":"Briat","year":"2009","journal-title":"Annals of Botany"},{"key":"2026041420070474900_CIT0006","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1105\/tpc.104.024315","article-title":"The essential basic helix-loop-helix protein FIT1 is required for the iron deficiency response","volume":"16","author":"Colangelo","year":"2004","journal-title":"The Plant Cell"},{"key":"2026041420070474900_CIT0007","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/pcp\/pcz079","article-title":"Iron biofortification of staple crops: lessons and challenges in plant genetics","volume":"60","author":"Connorton","year":"2019","journal-title":"Plant & Cell Physiology"},{"key":"2026041420070474900_CIT0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aob\/mcn207","article-title":"Metal movement within the plant: contribution of nicotianamine and yellow stripe 1-like transporters","volume":"103","author":"Curie","year":"2009","journal-title":"Annals of Botany"},{"key":"2026041420070474900_CIT0009","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35053080","article-title":"Maize yellow stripe1 encodes a membrane protein directly involved in Fe(III) uptake","volume":"409","author":"Curie","year":"2001","journal-title":"Nature"},{"key":"2026041420070474900_CIT0010","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s00425-020-03386-2","article-title":"The Mitochondrial Iron-Regulated (MIR) gene is Oryza genus specific and evolved before speciation within the Oryza sativa complex","volume":"251","author":"de Oliveira","year":"2020","journal-title":"Planta"},{"key":"2026041420070474900_CIT0011","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-313X.2004.02128.x","article-title":"Arabidopsis Yellow Stripe-Like2 (YSL2): a metal-regulated gene encoding a plasma membrane transporter of nicotianamine-metal complexes","volume":"39","author":"DiDonato","year":"2004","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0012","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1073\/pnas.93.11.5624","article-title":"A novel iron-regulated metal transporter from plants identified by functional expression in yeast","volume":"93","author":"Eide","year":"1996","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2026041420070474900_CIT0013","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1105\/tpc.19.00541","article-title":"The transcription factor bHLH121 interacts with bHLH105 (ILR3) and its closest homologs to regulate iron homeostasis in Arabidopsis","volume":"32","author":"Gao","year":"2020","journal-title":"The Plant Cell"},{"key":"2026041420070474900_CIT0014","doi-asserted-by":"crossref","first-page":"e110468","DOI":"10.1371\/journal.pone.0110468","article-title":"Vacuolar-Iron-Transporter1-Like proteins mediate iron homeostasis in Arabidopsis","volume":"9","author":"Gollhofer","year":"2014","journal-title":"PLoS One"},{"key":"2026041420070474900_CIT0015","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/s41477-018-0266-y","article-title":"IRON MAN is a ubiquitous family of peptides that control iron transport in plants","volume":"4","author":"Grillet","year":"2018","journal-title":"Nature Plants"},{"key":"2026041420070474900_CIT0016","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1104\/pp.104.3.815","article-title":"Iron: Nutritious, noxious, and not readily available","volume":"104","author":"Guerinot","year":"1994","journal-title":"Plant Physiology"},{"key":"2026041420070474900_CIT0017","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-313X.1994.6020271.x","article-title":"Efficient transformation of rice (Oryza sativa L.) mediated by Agrobacterium and sequence analysis of the boundaries of the T-DNA","volume":"6","author":"Hiei","year":"1994","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0018","first-page":"159","article-title":"Nicotianamine synthase gene expression differs in barley and rice under Fe-deficient conditions","volume":"25","author":"Higuchi","year":"2001","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0019","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1039\/C7MT00152E","article-title":"BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana","volume":"9","author":"Hindt","year":"2017","journal-title":"Metallomics"},{"key":"2026041420070474900_CIT0020","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/pcp\/pcy145","article-title":"The putative peptide gene FEP1 regulates iron deficiency response in Arabidopsis","volume":"59","author":"Hirayama","year":"2018","journal-title":"Plant & Cell Physiology"},{"key":"2026041420070474900_CIT0021","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1046\/j.1365-313X.2003.01878.x","article-title":"Three rice nicotianamine synthase genes, OsNAS1, OsNAS2, and OsNAS3 are expressed in cells involved in long-distance transport of iron and differentially regulated by iron","volume":"36","author":"Inoue","year":"2003","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0022","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1074\/jbc.M806042200","article-title":"Rice OsYSL15 is an iron-regulated iron(III)-deoxymugineic acid transporter expressed in the roots and is essential for iron uptake in early growth of the seedlings","volume":"284","author":"Inoue","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"2026041420070474900_CIT0023","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11103-007-9262-8","article-title":"Identification and localisation of the rice nicotianamine aminotransferase gene OsNAAT1 expression suggests the site of phytosiderophore synthesis in rice","volume":"66","author":"Inoue","year":"2008","journal-title":"Plant Molecular Biology"},{"key":"2026041420070474900_CIT0024","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/mp\/ssp051","article-title":"Rice-specific mitochondrial iron-regulated gene (MIR) plays an important role in iron homeostasis","volume":"2","author":"Ishimaru","year":"2009","journal-title":"Molecular Plant"},{"key":"2026041420070474900_CIT0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-313X.2010.04158.x","article-title":"Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese","volume":"62","author":"Ishimaru","year":"2010","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0026","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-313X.2005.02624.x","article-title":"Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+","volume":"45","author":"Ishimaru","year":"2006","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0027","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1939-8433-6-16","article-title":"Rice genes involved in phytosiderophore biosynthesis are synchronously regulated during the early stages of iron deficiency in roots","volume":"6","author":"Itai","year":"2013","journal-title":"Rice"},{"key":"2026041420070474900_CIT0028","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.febslet.2004.10.062","article-title":"FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana","volume":"577","author":"Jakoby","year":"2004","journal-title":"FEBS Letters"},{"key":"2026041420070474900_CIT0029","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1038\/s41598-019-43600-0","article-title":"Lasy-Seq: a high-throughput library preparation method for RNA-Seq and its application in the analysis of plant responses to fluctuating temperatures","volume":"9","author":"Kamitani","year":"2019","journal-title":"Scientific Reports"},{"key":"2026041420070474900_CIT0030","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1360-1385(02)02251-3","article-title":"GATEWAYTM vectors for Agrobacterium-mediated plant transformation","volume":"7","author":"Karimi","year":"2002","journal-title":"Trends in Plant Science"},{"key":"2026041420070474900_CIT0031","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/pcp\/pci196","article-title":"Increased nicotianamine biosynthesis confers enhanced tolerance of high levels of metals, in particular nickel, to plants","volume":"46","author":"Kim","year":"2005","journal-title":"Plant & Cell Physiology"},{"key":"2026041420070474900_CIT0032","doi-asserted-by":"crossref","first-page":"24933","DOI":"10.1073\/pnas.1916892116","article-title":"The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI","volume":"116","author":"Kim","year":"2019","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2026041420070474900_CIT0033","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/pcp\/pcz038","article-title":"Understanding the complexity of iron sensing and signaling cascades in plants","volume":"60","author":"Kobayashi","year":"2019","journal-title":"Plant & Cell Physiology"},{"key":"2026041420070474900_CIT0037","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12284-014-0027-0","article-title":"Iron deficiency responses in rice roots","volume":"7","author":"Kobayashi","year":"2014","journal-title":"Rice"},{"key":"2026041420070474900_CIT0034","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/j.1365-313X.2009.04015.x","article-title":"The rice transcription factor IDEF1 is essential for the early response to iron deficiency, and induces vegetative expression of late embryogenesis abundant genes","volume":"60","author":"Kobayashi","year":"2009","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0035","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1038\/ncomms3792","article-title":"Iron-binding haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation","volume":"4","author":"Kobayashi","year":"2013","journal-title":"Nature Communications"},{"key":"2026041420070474900_CIT0036","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/s004250000453","article-title":"In vivo evidence that Ids3 from Hordeum vulgare encodes a dioxygenase that converts 2\u2032-deoxymugineic acid to mugineic acid in transgenic rice","volume":"212","author":"Kobayashi","year":"2001","journal-title":"Planta"},{"key":"2026041420070474900_CIT0038","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-arplant-042811-105522","article-title":"Iron uptake, translocation, and regulation in higher plants","volume":"63","author":"Kobayashi","year":"2012","journal-title":"Annual Review of Plant Biology"},{"key":"2026041420070474900_CIT0039","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.freeradbiomed.2018.10.439","article-title":"Iron transport and its regulation in plants","volume":"133","author":"Kobayashi","year":"2019","journal-title":"Free Radical Biology & Medicine"},{"key":"2026041420070474900_CIT0040","doi-asserted-by":"crossref","first-page":"19150","DOI":"10.1073\/pnas.0707010104","article-title":"The transcription factor IDEF1 regulates the response to and tolerance of iron deficiency in plants","volume":"104","author":"Kobayashi","year":"2007","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2026041420070474900_CIT0041","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s11103-019-00917-8","article-title":"OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice","volume":"101","author":"Kobayashi","year":"2019","journal-title":"Plant Molecular Biology"},{"key":"2026041420070474900_CIT0042","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1093\/jxb\/eri131","article-title":"Expression of iron-acquisition-related genes in iron-deficient rice is co-ordinately induced by partially conserved iron-deficiency-responsive elements","volume":"56","author":"Kobayashi","year":"2005","journal-title":"Journal of Experimental Botany"},{"key":"2026041420070474900_CIT0043","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-313X.2004.02146.x","article-title":"OsYSL2 is a rice metal-nicotianamine transporter that is regulated by iron and expressed in the phloem","volume":"39","author":"Koike","year":"2004","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0044","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1104\/pp.109.135418","article-title":"Disruption of OsYSL15 leads to iron inefficiency in rice plants","volume":"150","author":"Lee","year":"2009","journal-title":"Plant Physiology"},{"key":"2026041420070474900_CIT0045","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.molp.2020.01.006","article-title":"bHLH121 functions as a direct link that facilitates the activation of FIT by bHLH IVc transcription factors for maintaining Fe homeostasis in Arabidopsis","volume":"13","author":"Lei","year":"2020","journal-title":"Molecular Plant"},{"key":"2026041420070474900_CIT0046","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1365-313X.2005.02569.x","article-title":"A loss-of-function mutation in AtYSL1 reveals its role in iron and nicotianamine seed loading","volume":"44","author":"Le Jean","year":"2005","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0047","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/jipb.12933","article-title":"Oryza sativa FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT\/OsbHLH156) interacts with OsIRO2 to regulate iron homeostasis","volume":"62","author":"Liang","year":"2020","journal-title":"Journal of Integrative Plant Biology"},{"key":"2026041420070474900_CIT0048","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1105\/tpc.110.074096","article-title":"The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots","volume":"22","author":"Long","year":"2010","journal-title":"The Plant Cell"},{"key":"2026041420070474900_CIT0049","volume-title":"Mineral nutrition of higher plants,","author":"Marschner","year":"1995","edition":"2"},{"key":"2026041420070474900_CIT0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-94-011-3294-7_23","article-title":"Why are young rice plants highly susceptible to iron deficiency?","volume-title":"Iron nutrition and interactions in plants","author":"Mori","year":"1991"},{"key":"2026041420070474900_CIT0051","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1074\/jbc.M110.180026","article-title":"Phytosiderophore efflux transporters are crucial for iron acquisition in graminaceous plants","volume":"286","author":"Nozoye","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"key":"2026041420070474900_CIT0052","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s11103-011-9752-6","article-title":"OsIRO2 is responsible for iron utilization in rice and improves growth and yield in calcareous soil","volume":"75","author":"Ogo","year":"2011","journal-title":"Plant Molecular Biology"},{"key":"2026041420070474900_CIT0053","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-313X.2007.03149.x","article-title":"The rice bHLH protein OsIRO2 is an essential regulator of the genes involved in Fe uptake under Fe-deficient conditions","volume":"51","author":"Ogo","year":"2007","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0054","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/nph.12577","article-title":"Spatial transcriptomes of iron-deficient and cadmium-stressed rice","volume":"201","author":"Ogo","year":"2014","journal-title":"New Phytologist"},{"key":"2026041420070474900_CIT0055","doi-asserted-by":"crossref","first-page":"13407","DOI":"10.1074\/jbc.M708732200","article-title":"A novel NAC transcription factor IDEF2 that recognizes the iron deficiency-responsive element 2 regulates the genes involved in iron homeostasis in plants","volume":"283","author":"Ogo","year":"2008","journal-title":"The Journal of Biological Chemistry"},{"key":"2026041420070474900_CIT0056","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41589-018-0019-2","article-title":"Biosynthesis of redox-active metabolites in response to iron deficiency in plants","volume":"14","author":"Rajniak","year":"2018","journal-title":"Nature Chemical Biology"},{"key":"2026041420070474900_CIT0057","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/17800","article-title":"A ferric-chelate reductase for iron uptake from soils","volume":"397","author":"Robinson","year":"1999","journal-title":"Nature"},{"key":"2026041420070474900_CIT0058","doi-asserted-by":"crossref","first-page":"17584","DOI":"10.1073\/pnas.1907971116","article-title":"Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling","volume":"116","author":"Rodr\u00edguez-Celma","year":"2019","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2026041420070474900_CIT0059","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1104\/pp.80.1.175","article-title":"Evidence for a specific uptake system for iron phytosiderophores in roots of grasses","volume":"80","author":"R\u00f6mheld","year":"1986","journal-title":"Plant Physiology"},{"key":"2026041420070474900_CIT0060","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.plaphy.2005.02.007","article-title":"Two plasma membrane H+-ATPase genes are differentially expressed in iron-deficient cucumber plants","volume":"43","author":"Santi","year":"2005","journal-title":"Plant Physiology and Biochemistry"},{"key":"2026041420070474900_CIT0061","doi-asserted-by":"crossref","first-page":"D1141","DOI":"10.1093\/nar\/gkq1085","article-title":"RiceXPro: a platform for monitoring gene expression in japonica rice grown under natural field conditions","volume":"39","author":"Sato","year":"2011","journal-title":"Nucleic Acids Research"},{"key":"2026041420070474900_CIT0062","doi-asserted-by":"crossref","first-page":"D1206","DOI":"10.1093\/nar\/gks1125","article-title":"RiceXPro version 3.0: expanding the informatics resource for rice transcriptome","volume":"41","author":"Sato","year":"2013","journal-title":"Nucleic Acids Research"},{"key":"2026041420070474900_CIT0063","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/pcp\/pci081","article-title":"A putative function for the Arabidopsis Fe-phytosiderophore transporter homolog AtYSL2 in Fe and Zn homeostasis","volume":"46","author":"Schaaf","year":"2005","journal-title":"Plant & Cell Physiology"},{"key":"2026041420070474900_CIT0064","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/jxb\/eraa012","article-title":"FIT, a regulatory hub for iron deficiency and stress signaling in roots, and FIT-dependent and -independent gene signatures","volume":"71","author":"Schwarz","year":"2020","journal-title":"Journal of Experimental Botany"},{"key":"2026041420070474900_CIT0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1104\/pp.114.250837","article-title":"Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors","volume":"167","author":"Selote","year":"2015","journal-title":"Plant Physiology"},{"key":"2026041420070474900_CIT0066","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s11103-020-01065-0","article-title":"Defects in the rice aconitase-encoding OsACO1 gene alter iron homeostasis","volume":"104","author":"Senoura","year":"2020","journal-title":"Plant Molecular Biology"},{"key":"2026041420070474900_CIT0067","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/nph.13633","article-title":"Flavins secreted by roots of iron-deficient Beta vulgaris enable mining of ferric oxide via reductive mechanisms","volume":"209","author":"Sis\u00f3-Terraza","year":"2016","journal-title":"New Phytologist"},{"key":"2026041420070474900_CIT0068","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.plantsci.2009.08.001","article-title":"Differential regulation of the two rice ferritin genes (OsFER1 and OsFER2)","volume":"177","author":"Stein","year":"2009","journal-title":"Plant Science"},{"key":"2026041420070474900_CIT0069","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/pcp\/pcz076","article-title":"The age of coumarins in plant\u2013microbe interactions","volume":"60","author":"Stringlis","year":"2019","journal-title":"Plant and Cell Physiology"},{"key":"2026041420070474900_CIT0070","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/00380768.1976.10433004","article-title":"Naturally occurring iron-chelating compounds in oat- and rice-root washing. I. Activity measurement and preliminary characterization","volume":"22","author":"Takagi","year":"1976","journal-title":"Soil Science and Plant Nutrition"},{"key":"2026041420070474900_CIT0071","doi-asserted-by":"crossref","DOI":"10.1080\/00380768.2020.1783966","article-title":"The bHLH protein OsIRO3 is critical for plant survival and iron (Fe) homeostasis in rice (Oryza sativa L.) under Fe-deficient conditions","author":"Wang","year":"2020","journal-title":"Soil Science and Plant Nutrition"},{"key":"2026041420070474900_CIT0072","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/nph.16232","article-title":"A transcription factor OsbHLH156 regulates Strategy II iron acquisition through localising IRO2 to the nucleus in rice","volume":"225","author":"Wang","year":"2020","journal-title":"New Phytologist"},{"key":"2026041420070474900_CIT0073","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1104\/pp.106.082586","article-title":"Mutations in Arabidopsis yellow stripe-like1 and yellow stripe-like3 reveal their roles in metal ion homeostasis and loading of metal ions in seeds","volume":"141","author":"Waters","year":"2006","journal-title":"Plant Physiology"},{"key":"2026041420070474900_CIT0074","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/pce.13655","article-title":"Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis","volume":"43","author":"Zhang","year":"2020","journal-title":"Plant, Cell & Environment"},{"key":"2026041420070474900_CIT0075","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1104\/pp.17.00794","article-title":"POSITIVE REGULATOR OF IRON HOMEOSTASIS1, OsPRI1, facilitates iron homeostasis","volume":"175","author":"Zhang","year":"2017","journal-title":"Plant Physiology"},{"key":"2026041420070474900_CIT0076","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1365-313X.2012.05088.x","article-title":"Vacuolar membrane transporters OsVIT1 and OsVIT2 modulate iron translocation between flag leaves and seeds in rice","volume":"72","author":"Zhang","year":"2012","journal-title":"The Plant Journal"},{"key":"2026041420070474900_CIT0077","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1471-2229-10-166","article-title":"Identification of a novel iron regulated basic helix-loop-helix protein involved in Fe homeostasis in Oryza sativa","volume":"10","author":"Zheng","year":"2010","journal-title":"BMC Plant Biology"}],"container-title":["Journal of Experimental Botany"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jxb\/advance-article-pdf\/doi\/10.1093\/jxb\/eraa546\/35129535\/eraa546.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jxb\/article-pdf\/72\/6\/2196\/36621933\/eraa546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jxb\/article-pdf\/72\/6\/2196\/36621933\/eraa546.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:13:18Z","timestamp":1776211998000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jxb\/article\/72\/6\/2196\/5989633"}},"subtitle":[],"editor":[{"given":"Sebastien","family":"Thomine","sequence":"additional","affiliation":[{"name":"CNRS ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":77,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,11,18]]},"published-print":{"date-parts":[[2021,3,17]]}},"URL":"https:\/\/doi.org\/10.1093\/jxb\/eraa546","relation":{},"ISSN":["0022-0957","1460-2431"],"issn-type":[{"value":"0022-0957","type":"print"},{"value":"1460-2431","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,17]]},"published":{"date-parts":[[2020,11,18]]}}}