{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:38:10Z","timestamp":1784205490007,"version":"3.55.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM127759"],"award-info":[{"award-number":["R01GM127759"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Iron bioavailability varies dramatically between soil types across the globe. This has given rise to high levels of natural variation in plant iron responses, allowing members of even a single species to thrive across a wide range of soil types. In recent years we have seen the use of genome-wide association analysis to identify natural variants underlying plant responses to changes in iron availability in both Arabidopsis and important crop species. These studies have provided insights into which genes have been important in shaping local adaptation to iron availability in different plant species and have allowed the discovery of novel regulators and mechanisms, not previously identified using mutagenesis approaches. Furthermore, these studies have allowed the identification of markers that can be used to accelerate breeding of future elite varieties with increased resilience to iron stress and improved nutritional quality. The studies highlighted here show that, in addition to studying plant responses to iron alone, it is important to consider these responses within the context of plant nutrition more broadly and to also consider iron regulation in relation to additional traits of agronomic importance such as yield and disease resistance.<\/jats:p>","DOI":"10.1093\/jxb\/erab012","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T12:19:33Z","timestamp":1610799573000},"page":"2154-2164","source":"Crossref","is-referenced-by-count":9,"title":["Using natural variation to understand plant responses to iron availability"],"prefix":"10.1093","volume":"72","author":[{"given":"Charlotte N","family":"Miller","sequence":"first","affiliation":[{"name":"Salk Institute For Biological Studies, Plant Molecular and Cellular Biology Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-7290","authenticated-orcid":false,"given":"Wolfgang","family":"Busch","sequence":"additional","affiliation":[{"name":"Salk Institute For Biological Studies, Plant Molecular and Cellular Biology Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"2021031707393907800_CIT0001","first-page":"164","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"Journal of Research in Medical Sciences"},{"key":"2021031707393907800_CIT0002","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12870-020-2237-5","article-title":"Deconstructing the genetic architecture of iron deficiency chlorosis in soybean using genome-wide approaches","volume":"20","author":"Assefa","year":"2020","journal-title":"BMC Plant Biology"},{"key":"2021031707393907800_CIT0003","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.plantsci.2015.08.022","article-title":"Immunity to plant pathogens and iron homeostasis","volume":"240","author":"Aznar","year":"2015","journal-title":"Plant Science"},{"key":"2021031707393907800_CIT0004","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3389\/fpls.2018.01002","article-title":"Field-based scoring of soybean iron deficiency chlorosis using RGB imaging and statistical learning","volume":"9","author":"Bai","year":"2018","journal-title":"Frontiers in Plant Science"},{"key":"2021031707393907800_CIT0005","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jpln.200520504","article-title":"Iron toxicity in rice\u2014conditions and management concepts","volume":"168","author":"Becker","year":"2005","journal-title":"Journal of Plant Nutrition and Soil Science"},{"key":"2021031707393907800_CIT0006","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/mchj.1998.1600","article-title":"Determination of trace elements in power plant emissions by inductively coupled plasma mass spectrometry: comparison with other spectrometric techniques","volume":"59","author":"Bettinelli","year":"1998","journal-title":"Microchemical Journal"},{"key":"2021031707393907800_CIT0007","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.3390\/ijms19103237","article-title":"Genome-wide association study reveals novel genomic regions associated with 10 grain minerals in synthetic hexaploid wheat","volume":"19","author":"Bhatta","year":"2018","journal-title":"International Journal of Molecular Science"},{"key":"2021031707393907800_CIT0008","doi-asserted-by":"crossref","first-page":"e1008392","DOI":"10.1371\/journal.pgen.1008392","article-title":"Systems genomics approaches provide new insights into Arabidopsis thaliana root growth regulation under combinatorial mineral nutrient limitation","volume":"15","author":"Bouain","year":"2019","journal-title":"PLoS Genetics"},{"key":"2021031707393907800_CIT0009","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1073\/pnas.1813852116","article-title":"Allele frequency dynamics in a pedigreed natural population","volume":"116","author":"Chen","year":"2019","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2021031707393907800_CIT0010","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1104\/pp.110.161109","article-title":"Nitric oxide acts downstream of auxin to trigger root ferric-chelate reductase activity in response to iron deficiency in Arabidopsis","volume":"154","author":"Chen","year":"2010","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0011","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0065-2113(08)60326-0","article-title":"Iron nutrition of plants in calcareous soils","volume":"35","author":"Chen","year":"1982","journal-title":"Advances in Agronomy"},{"key":"2021031707393907800_CIT0012","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1104\/pp.103.025122","article-title":"Overexpression of the FRO2 ferric chelate reductase confers tolerance to growth on low iron and uncovers posttranscriptional control","volume":"133","author":"Connolly","year":"2003","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0013","doi-asserted-by":"crossref","first-page":"REVIEWS1024","DOI":"10.1186\/gb-2002-3-8-reviews1024","article-title":"Iron stress in plants","volume":"3","author":"Connolly","year":"2002","journal-title":"Genome Biology"},{"key":"2021031707393907800_CIT0014","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/mp\/ssr015","article-title":"Transporters contributing to iron trafficking in plants","volume":"4","author":"Conte","year":"2011","journal-title":"Molecular Plant"},{"key":"2021031707393907800_CIT0015","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1105\/tpc.10.5.741","article-title":"Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation","volume":"10","author":"Coschigano","year":"1998","journal-title":"The Plant Cell"},{"key":"2021031707393907800_CIT0016","doi-asserted-by":"crossref","first-page":"e05255","DOI":"10.7554\/eLife.05255","article-title":"DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation","volume":"4","author":"Dubin","year":"2015","journal-title":"eLife"},{"key":"2021031707393907800_CIT0017","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1080\/01904160802244902","article-title":"Iron toxicity in lowland rice","volume":"31","author":"Fageria","year":"2008","journal-title":"Journal of Plant Nutrition"},{"key":"2021031707393907800_CIT0018","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1105\/tpc.104.024372","article-title":"Arabidopsis formin AtFH6 is a plasma membrane-associated protein upregulated in giant cells induced by parasitic nematodes","volume":"16","author":"Favery","year":"2004","journal-title":"The Plant Cell"},{"key":"2021031707393907800_CIT0019","doi-asserted-by":"crossref","first-page":"144484","DOI":"10.1016\/j.gene.2020.144484","article-title":"Identification and characterization of the glutathione S-transferase (GST) family in radish reveals a likely role in anthocyanin biosynthesis and heavy metal stress tolerance","volume":"743","author":"Gao","year":"2020","journal-title":"Gene"},{"key":"2021031707393907800_CIT0020","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cell.2016.05.063","article-title":"1,135 genomes reveal the global pattern of polymorphism in Arabidopsis thaliana","volume":"166","author":"1001 Genomes Consortium.","year":"2016","journal-title":"Cell"},{"key":"2021031707393907800_CIT0021","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1071\/FP16128","article-title":"GrowScreen-PaGe, a non-invasive, high-throughput phenotyping system based on germination paper to quantify crop phenotypic diversity and plasticity of root traits under varying nutrient supply","volume":"44","author":"Gioia","year":"2016","journal-title":"Functional Plant Biology"},{"key":"2021031707393907800_CIT0022","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1073\/pnas.95.12.7220","article-title":"Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency","volume":"95","author":"Grotz","year":"1998","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2021031707393907800_CIT0023","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nbt.2302","article-title":"Associative transcriptomics of traits in the polyploid crop species Brassica napus","volume":"30","author":"Harper","year":"2012","journal-title":"Nature Biotechnology"},{"key":"2021031707393907800_CIT0024","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1104\/pp.111.189167","article-title":"The effect of a genetically reduced plasma membrane protonmotive force on vegetative growth of Arabidopsis","volume":"158","author":"Haruta","year":"2012","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0025","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1039\/C7MT00152E","article-title":"BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana","volume":"9","author":"Hindt","year":"2017","journal-title":"Metallomics"},{"key":"2021031707393907800_CIT0026","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00122-018-3089-3","article-title":"Identification and validation of genomic regions influencing kernel zinc and iron in maize","volume":"131","author":"Hindu","year":"2018","journal-title":"Theoretical and Applied Genetics"},{"key":"2021031707393907800_CIT0027","doi-asserted-by":"crossref","first-page":"872875","DOI":"10.1155\/2012\/872875","article-title":"Molecular mechanism of heavy metal toxicity and tolerance in plants: central role of glutathione in detoxification of reactive oxygen species and methylglyoxal and in heavy metal chelation","volume":"2012","author":"Hossain","year":"2012","journal-title":"Journal of Botany"},{"key":"2021031707393907800_CIT0028","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fmicb.2012.00096","article-title":"Redox transformations of iron at extremely low pH: fundamental and applied aspects","volume":"3","author":"Johnson","year":"2012","journal-title":"Frontiers in Microbiology"},{"key":"2021031707393907800_CIT0029","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1104\/pp.16.00619","article-title":"Unraveling K63 polyubiquitination networks by sensor-based proteomics","volume":"171","author":"Johnson","year":"2016","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0030","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.cell.2016.06.044","article-title":"Epigenomic diversity in a global collection of Arabidopsis thaliana accessions","volume":"166","author":"Kawakatsu","year":"2016","journal-title":"Cell"},{"key":"2021031707393907800_CIT0031","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.1132563","article-title":"Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1","volume":"314","author":"Kim","year":"2006","journal-title":"Science"},{"key":"2021031707393907800_CIT0032","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1104\/pp.109.136374","article-title":"The analysis of Arabidopsis nicotianamine synthase mutants reveals functions for nicotianamine in seed iron loading and iron deficiency responses","volume":"150","author":"Klatte","year":"2009","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0033","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-4939-7125-1_15","article-title":"AraNet: a network biology server for Arabidopsis thaliana and other non-model plant species","volume":"1629","author":"Lee","year":"2017","journal-title":"Methods in Molecular Biology"},{"key":"2021031707393907800_CIT0034","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1365-313X.2005.02569.x","article-title":"A loss-of-function mutation in AtYSL1 reveals its role in iron and nicotianamine seed loading","volume":"44","author":"Le Jean","year":"2005","journal-title":"The Plant Journal"},{"key":"2021031707393907800_CIT0035","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1038\/s41467-019-11892-5","article-title":"GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity","volume":"10","author":"Li","year":"2019","journal-title":"Nature Communications"},{"key":"2021031707393907800_CIT0036","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1104\/pp.15.01827","article-title":"Two bHLH transcription factors, bHLH34 and bHLH104, regulate iron homeostasis in Arabidopsis thaliana","volume":"170","author":"Li","year":"2016","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0037","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1023\/A:1009637320805","article-title":"Mapping genetic loci for iron deficiency chlorosis in soybean","volume":"3","author":"Lin","year":"1997","journal-title":"Molecular Breeding"},{"key":"2021031707393907800_CIT0038","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1080\/01904160009382154","article-title":"Molecular characterization of iron deficiency chlorosis in soybean","volume":"23","author":"Lin","year":"2000","journal-title":"Journal of Plant Nutrition"},{"key":"2021031707393907800_CIT0039","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/01904168209363012","article-title":"The chemistry of iron in soils and its availability to plants","volume":"5","author":"Lindsay","year":"1982","journal-title":"Journal of Plant Nutrition"},{"key":"2021031707393907800_CIT0040","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1105\/tpc.110.074096","article-title":"The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots","volume":"22","author":"Long","year":"2010","journal-title":"The Plant Cell"},{"key":"2021031707393907800_CIT0041","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tplants.2006.12.001","article-title":"Methods for linkage disequilibrium mapping in crops","volume":"12","author":"Mackay","year":"2007","journal-title":"Trends in Plant Science"},{"key":"2021031707393907800_CIT0042","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.envexpbot.2005.05.006","article-title":"The effects of short-term exposition to Cd, excess Cu ions and jasmonate on oxidative stress appearing in Arabidopsis thaliana","volume":"57","author":"Maksymiec","year":"2006","journal-title":"Environmental and Experimental Botany"},{"key":"2021031707393907800_CIT0043","doi-asserted-by":"crossref","first-page":"e107469","DOI":"10.1371\/journal.pone.0107469","article-title":"Genome-wide association studies identifies seven major regions responsible for iron deficiency chlorosis in soybean (Glycine max)","volume":"9","author":"Mamidi","year":"2014","journal-title":"PLoS One"},{"key":"2021031707393907800_CIT0044","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s00122-015-2569-y","article-title":"Loci, genes, and mechanisms associated with tolerance to ferrous iron toxicity in rice (Oryza sativa L.)","volume":"128","author":"Matthus","year":"2015","journal-title":"Theoretical and Applied Genetics"},{"key":"2021031707393907800_CIT0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1679\/aohc.70.1","article-title":"Nonheme-iron histochemistry for light and electron microscopy: a historical, theoretical and technical review","volume":"70","author":"Meguro","year":"2007","journal-title":"Archives of Histology and Cytology"},{"key":"2021031707393907800_CIT0046","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/s12864-016-2775-2","article-title":"Elucidation of the genetic basis of variation for stem strength characteristics in bread wheat by associative transcriptomics","volume":"17","author":"Miller","year":"2016","journal-title":"BMC Genomics"},{"key":"2021031707393907800_CIT0047","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1105\/tpc.18.00577","article-title":"Variation in expression of the HECT E3 ligase UPL3 modulates LEC2 levels, seed size, and crop yields in Brassica napus","volume":"31","author":"Miller","year":"2019","journal-title":"The Plant Cell"},{"key":"2021031707393907800_CIT0048","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1021\/cr900112r","article-title":"Iron uptake and transport in plants: the good, the bad, and the ionome","volume":"109","author":"Morrissey","year":"2009","journal-title":"Chemical Reviews"},{"key":"2021031707393907800_CIT0049","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1074\/jbc.M108796200","article-title":"Characterization of the iron\u2013sulfur cluster coordinated by a cysteine cluster motif (CXXCXXXCX27C) in the Nqo3 subunit in the proton-translocating NADH-quinone oxidoreductase (NDH-1) of Thermus thermophilus HB-8","volume":"277","author":"Nakamaru-Ogiso","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"2021031707393907800_CIT0050","first-page":"42","article-title":"Nachweis von Eisenoxyd in gewissen Pigmenten","volume":"39","author":"Perls","year":"1867","journal-title":"Archiv f\u00fcr Pathologische Anatomie und Physiologie und f\u00fcr Klinische Medicin"},{"key":"2021031707393907800_CIT0051","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3390\/biology1020196","article-title":"Soil oxidation\u2013reduction in wetlands and its impact on plant functioning","volume":"1","author":"Pezeshki","year":"2012","journal-title":"Biology"},{"key":"2021031707393907800_CIT0052","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.molp.2014.11.014","article-title":"Iron- and ferritin-dependent reactive oxygen species distribution: impact on Arabidopsis root system architecture","volume":"8","author":"Reyt","year":"2015","journal-title":"Molecular Plant"},{"key":"2021031707393907800_CIT0053","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/17800","article-title":"A ferric-chelate reductase for iron uptake from soils","volume":"397","author":"Robinson","year":"1999","journal-title":"Nature"},{"key":"2021031707393907800_CIT0054","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fpls.2013.00276","article-title":"The transcriptional response of Arabidopsis leaves to Fe deficiency","volume":"4","author":"Rodr\u00edguez-Celma","year":"2013","journal-title":"Frontiers in Plant Science"},{"key":"2021031707393907800_CIT0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02205934","article-title":"Iron toxicity to rice in an acid sulfate soil as influenced by water regimes","volume":"51","author":"Sahrawat","year":"1979","journal-title":"Plant and Soil"},{"key":"2021031707393907800_CIT0056","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1081\/PLN-200025869","article-title":"Iron toxicity in wetland rice and the role of other nutrients","volume":"27","author":"Sahrawat","year":"2005","journal-title":"Journal of Plant Nutrition"},{"key":"2021031707393907800_CIT0057","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-313X.2008.03761.x","article-title":"The Arabidopsis glutathione transferase gene family displays complex stress regulation and co-silencing multiple genes results in altered metabolic sensitivity to oxidative stress","volume":"58","author":"Sappl","year":"2009","journal-title":"The Plant Journal"},{"key":"2021031707393907800_CIT0058","doi-asserted-by":"crossref","first-page":"15603","DOI":"10.1038\/ncomms15603","article-title":"Natural allelic variation of FRO2 modulates Arabidopsis root growth under iron deficiency","volume":"8","author":"Satbhai","year":"2017","journal-title":"Nature Communications"},{"key":"2021031707393907800_CIT0059","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature11968","article-title":"Patterns of population epigenomic diversity","volume":"495","author":"Schmitz","year":"2013","journal-title":"Nature"},{"key":"2021031707393907800_CIT0060","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1105\/tpc.112.099077","article-title":"Nicotianamine functions in the phloem-based transport of iron to sink organs, in pollen development and pollen tube growth in Arabidopsis","volume":"24","author":"Schuler","year":"2012","journal-title":"The Plant Cell"},{"key":"2021031707393907800_CIT0061","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1104\/pp.114.250837","article-title":"Iron-binding E3 ligase mediates iron response in plants by targeting basic helix\u2013loop\u2013helix transcription factors","volume":"167","author":"Selote","year":"2015","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0062","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1104\/pp.18.00217","article-title":"EZ-Root-VIS: a software pipeline for the rapid analysis and visual reconstruction of root system architecture","volume":"177","author":"Shahzad","year":"2018","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0063","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/aob\/mcl281","article-title":"Natural genetic variation in Arabidopsis: tools, traits and prospects for evolutionary ecology","volume":"99","author":"Shindo","year":"2007","journal-title":"Annals of Botany"},{"key":"2021031707393907800_CIT0064","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/1343943X.2016.1186496","article-title":"Soil-based screening for iron toxicity tolerance in rice using pots","volume":"19","author":"Sikirou","year":"2016","journal-title":"Plant Production Science"},{"key":"2021031707393907800_CIT0065","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1105\/tpc.18.00207","article-title":"Systemic upregulation of MTP2- and HMA2-mediated Zn partitioning to the shoot supplements local Zn deficiency responses","volume":"30","author":"Sinclair","year":"2018","journal-title":"The Plant Cell"},{"key":"2021031707393907800_CIT0066","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1105\/tpc.114.124032","article-title":"A scalable open-source pipeline for large-scale root phenotyping of Arabidopsis","volume":"26","author":"Slovak","year":"2014","journal-title":"The Plant Cell"},{"key":"2021031707393907800_CIT0067","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jfca.2018.03.004","article-title":"Potential and application of X-ray fluorescence spectrometry to estimate iron and zinc concentration in potato tubers","volume":"70","author":"Sosa","year":"2018","journal-title":"Journal of Food Composition and Analysis"},{"key":"2021031707393907800_CIT0068","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s40626-014-0013-3","article-title":"Iron toxicity in field-cultivated rice: contrasting tolerance mechanisms in distinct cultivars","volume":"26","author":"Stein","year":"2014","journal-title":"Theoretical and Experimental Plant Physiology"},{"key":"2021031707393907800_CIT0069","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/jxb\/err343","article-title":"Use of natural variation reveals core genes in the transcriptome of iron-deficient Arabidopsis thaliana roots","volume":"63","author":"Stein","year":"2012","journal-title":"Journal of Experimental Botany"},{"key":"2021031707393907800_CIT0070","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2021031707393907800_CIT0071","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3389\/fpls.2017.02169","article-title":"The interaction between auxin and nitric oxide regulates root growth in response to iron deficiency in rice","volume":"8","author":"Sun","year":"2017","journal-title":"Frontiers in Plant Science"},{"key":"2021031707393907800_CIT0072","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1126\/science.1133649","article-title":"A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat","volume":"314","author":"Uauy","year":"2006","journal-title":"Science"},{"key":"2021031707393907800_CIT0073","doi-asserted-by":"crossref","first-page":"24050","DOI":"10.1038\/srep24050","article-title":"Genetic dissection of seed-iron and zinc concentrations in chickpea","volume":"6","author":"Upadhyaya","year":"2016","journal-title":"Scientific Reports"},{"key":"2021031707393907800_CIT0074","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1105\/tpc.001388","article-title":"IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth","volume":"14","author":"Vert","year":"2002","journal-title":"The Plant Cell"},{"key":"2021031707393907800_CIT0075","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1128\/IAI.72.3.1391-1396.2004","article-title":"An NADPH quinone reductase of Helicobacter pylori plays an important role in oxidative stress resistance and host colonization","volume":"72","author":"Wang","year":"2004","journal-title":"Infection and Immunity"},{"key":"2021031707393907800_CIT0076","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00425-007-0535-x","article-title":"Iron deficiency-mediated stress regulation of four subgroup Ib BHLH genes in Arabidopsis thaliana","volume":"226","author":"Wang","year":"2007","journal-title":"Planta"},{"key":"2021031707393907800_CIT0077","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1104\/pp.17.00694","article-title":"Transcriptome association identifies regulators of wheat spike architecture","volume":"175","author":"Wang","year":"2017","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0078","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1104\/pp.108.118562","article-title":"The effect of iron on the primary root elongation of Arabidopsis during phosphate deficiency","volume":"147","author":"Ward","year":"2008","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0079","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1101\/gad.1512007","article-title":"VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization","volume":"21","author":"Woo","year":"2007","journal-title":"Genes & Development"},{"key":"2021031707393907800_CIT0080","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/pcp\/pci163","article-title":"Molecular and biochemical characterization of the Fe(III) chelate reductase gene family in Arabidopsis thaliana","volume":"46","author":"Wu","year":"2005","journal-title":"Plant & Cell Physiology"},{"key":"2021031707393907800_CIT0081","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cj.2016.06.003","article-title":"Genetic mapping of quantitative trait loci in crops","volume":"5","author":"Xu","year":"2017","journal-title":"The Crop Journal"},{"key":"2021031707393907800_CIT0082","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1104\/pp.109.152728","article-title":"Transcriptional profiling of the Arabidopsis iron deficiency response reveals conserved transition metal homeostasis networks","volume":"152","author":"Yang","year":"2010","journal-title":"Plant Physiology"},{"key":"2021031707393907800_CIT0083","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1365-313X.1996.10050835.x","article-title":"Genetic evidence that induction of root Fe(III) chelate reductase activity is necessary for iron uptake under iron deficiency","volume":"10","author":"Yi","year":"1996","journal-title":"The Plant Journal"},{"key":"2021031707393907800_CIT0084","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/nph.15157","article-title":"Excess iron stress reduces root tip zone growth through nitric oxide-mediated repression of potassium homeostasis in Arabidopsis","volume":"219","author":"Zhang","year":"2018","journal-title":"New Phytologist"},{"key":"2021031707393907800_CIT0085","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.febslet.2015.03.034","article-title":"Arabidopsis mitochondrial voltage-dependent anion channel 3 (AtVDAC3) protein interacts with thioredoxin m2","volume":"589","author":"Zhang","year":"2015","journal-title":"FEBS Letters"},{"key":"2021031707393907800_CIT0086","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.3390\/ijms20102424","article-title":"The adaptive mechanism of plants to iron deficiency via iron uptake, transport, and homeostasis","volume":"20","author":"Zhang","year":"2019","journal-title":"International Journal of Molecular Science"}],"container-title":["Journal of Experimental Botany"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jxb\/advance-article-pdf\/doi\/10.1093\/jxb\/erab012\/36418946\/erab012.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jxb\/article-pdf\/72\/6\/2154\/36622019\/erab012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jxb\/article-pdf\/72\/6\/2154\/36622019\/erab012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T07:42:02Z","timestamp":1615966922000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jxb\/article\/72\/6\/2154\/6103165"}},"subtitle":[],"editor":[{"given":"Nicolaus","family":"von Wir\u00e9n","sequence":"additional","affiliation":[{"name":"Leibniz-Institute for Plant Genetics & Crop Plant Research, Germany"}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":86,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,1,18]]},"published-print":{"date-parts":[[2021,3,17]]}},"URL":"https:\/\/doi.org\/10.1093\/jxb\/erab012","relation":{},"ISSN":["0022-0957","1460-2431"],"issn-type":[{"value":"0022-0957","type":"print"},{"value":"1460-2431","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,17]]},"published":{"date-parts":[[2021,1,18]]}}}