{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:17:19Z","timestamp":1792199839771,"version":"4.4.0"},"reference-count":105,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HI 1471"],"award-info":[{"award-number":["HI 1471"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The adaptation of plant metabolism to stress-induced energy deficiency involves profound changes in amino acid metabolism. Anabolic reactions are suppressed, whereas respiratory pathways that use amino acids as alternative substrates are activated. This review highlights recent progress in unraveling the stress-induced amino acid oxidation pathways, their regulation, and the role of amino acids as signaling molecules. We present an updated map of the degradation pathways for lysine and the branched-chain amino acids. The regulation of amino acid metabolism during energy deprivation, including the coordinated induction of several catabolic pathways, is mediated by the balance between TOR and SnRK signaling. Recent findings indicate that some amino acids might act as nutrient signals in TOR activation and thus promote a shift from catabolic to anabolic pathways. The metabolism of the sulfur-containing amino acid cysteine is highly interconnected with TOR and SnRK signaling. Mechanistic details have recently been elucidated for cysteine signaling during the abscisic acid-dependent drought response. Local cysteine synthesis triggers abscisic acid production and, in addition, cysteine degradation produces the gaseous messenger hydrogen sulfide, which promotes stomatal closure via protein persulfidation. Amino acid signaling in plants is still an emerging topic with potential for fundamental discoveries.<\/jats:p>","DOI":"10.1093\/jxb\/erab182","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T16:43:01Z","timestamp":1619455381000},"page":"4634-4645","source":"Crossref","is-referenced-by-count":299,"title":["The role of amino acid metabolism in signaling and metabolic adaptation to stress-induced energy deficiency in plants"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3962-4174","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Heinemann","sequence":"first","affiliation":[{"name":"Institute for Plant Genetics, Department of Plant Proteomics, Leibniz University Hannover, Herrenh\u00e4user Stra\u00dfe, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-5241","authenticated-orcid":false,"given":"Tatjana M","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Institute for Plant Genetics, Department of Plant Proteomics, Leibniz University Hannover, Herrenh\u00e4user Stra\u00dfe, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,16]]},"reference":[{"key":"2021070808401363600_CIT0001","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00425-010-1130-0","article-title":"Polyamines: molecules with regulatory functions in plant abiotic stress tolerance","volume":"231","author":"Alc\u00e1zar","year":"2010","journal-title":"Planta"},{"key":"2021070808401363600_CIT0002","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1073\/pnas.1905142117","article-title":"The structural bases for agonist diversity in an Arabidopsis thaliana glutamate receptor-like channel","volume":"117","author":"Alfieri","year":"2020","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2021070808401363600_CIT0003","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1469-8137.2011.03889.x","article-title":"Cysteine homeostasis plays an essential role in plant immunity","volume":"193","author":"\u00c1lvarez","year":"2012","journal-title":"New Phytologist"},{"key":"2021070808401363600_CIT0004","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1105\/tpc.113.119370","article-title":"Genome-wide analysis of branched-chain amino acid levels in Arabidopsis seeds","volume":"25","author":"Angelovici","year":"2013","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0005","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1105\/tpc.110.075630","article-title":"Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria","volume":"22","author":"Ara\u00fajo","year":"2010","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0006","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1093\/jxb\/eraa054","article-title":"A balancing act: how plants integrate nitrogen and water signals","volume":"71","author":"Araus","year":"2020","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0007","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pbi.2016.12.004","article-title":"Shaping plant development through the SnRK1\u2013TOR metabolic regulators","volume":"35","author":"Baena-Gonz\u00e1lez","year":"2017","journal-title":"Current Opinion in Plant Biology"},{"key":"2021070808401363600_CIT0008","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pbi.2020.01.010","article-title":"SnRK1 and trehalose 6-phosphate \u2013 two ancient pathways converge to regulate plant metabolism and growth","volume":"55","author":"Baena-Gonz\u00e1lez","year":"2020","journal-title":"Current Opinion in Plant Biology"},{"key":"2021070808401363600_CIT0009","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature06069","article-title":"A central integrator of transcription networks in plant stress and energy signalling","volume":"448","author":"Baena-Gonz\u00e1lez","year":"2007","journal-title":"Nature"},{"key":"2021070808401363600_CIT0010","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1105\/tpc.18.00612","article-title":"Sulfate is incorporated into cysteine to trigger ABA production and stomatal closure","volume":"30","author":"Batool","year":"2018","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0011","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/BJ20120038","article-title":"Cysteine biosynthesis, in concert with a novel mechanism, contributes to sulfide detoxification in mitochondria of Arabidopsis thaliana","volume":"445","author":"Birke","year":"2012","journal-title":"Biochemical Journal"},{"key":"2021070808401363600_CIT0012","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/bs.mie.2014.11.027","article-title":"Sulfide detoxification in plant mitochondria","volume":"555","author":"Birke","year":"2015","journal-title":"Methods in Enzymology"},{"key":"2021070808401363600_CIT0013","first-page":"47","article-title":"Photosynthesis, a global sensor of environmental stress in green plants: stress signalling and adaptation","volume":"101","author":"Biswal","year":"2011","journal-title":"Current Science"},{"key":"2021070808401363600_CIT0014","volume-title":"Upstream regulators of the plant energy sensor SnRK1.","author":"Broeckx","year":"2018"},{"key":"2021070808401363600_CIT0015","doi-asserted-by":"crossref","first-page":"6215","DOI":"10.1093\/jxb\/erw416","article-title":"The plant energy sensor: evolutionary conservation and divergence of SnRK1 structure, regulation, and function","volume":"67","author":"Broeckx","year":"2016","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0016","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1093\/jxb\/ery459","article-title":"The magic \u2018hammer\u2019 of TOR: the multiple faces of a single pathway in the metabolic regulation of plant growth and development","volume":"70","author":"Caldana","year":"2019","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0017","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/tpj.12407","article-title":"Sulfate availability affects ABA levels and germination response to ABA and salt stress in Arabidopsis thaliana","volume":"77","author":"Cao","year":"2014","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0018","doi-asserted-by":"crossref","first-page":"e50747","DOI":"10.7554\/eLife.50747","article-title":"Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis","volume":"8","author":"Cao","year":"2019","journal-title":"eLife"},{"key":"2021070808401363600_CIT0019","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.molp.2020.01.004","article-title":"Hydrogen sulfide positively regulates abscisic acid signaling through persulfidation of SnRK2.6 in guard cells","volume":"13","author":"Chen","year":"2020","journal-title":"Molecular Plant"},{"key":"2021070808401363600_CIT0020","doi-asserted-by":"crossref","first-page":"E4920","DOI":"10.1073\/pnas.1805291115","article-title":"N-hydroxy-pipecolic acid is a mobile metabolite that induces systemic disease resistance in Arabidopsis","volume":"115","author":"Chen","year":"2018","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2021070808401363600_CIT0021","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1104\/pp.18.01439","article-title":"SULTR3s function in chloroplast sulfate uptake and affect ABA biosynthesis and the stress response","volume":"180","author":"Chen","year":"2019","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0022","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1105\/tpc.110.075390","article-title":"Heterodimers of the Arabidopsis transcription factors bZIP1 and bZIP53 reprogram amino acid metabolism during low energy stress","volume":"23","author":"Dietrich","year":"2011","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0023","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1365-313X.2011.04893.x","article-title":"Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination","volume":"70","author":"Ding","year":"2012","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0024","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1105\/tpc.16.00486","article-title":"Characterization of a pipecolic acid biosynthesis pathway required for systemic acquired resistance","volume":"28","author":"Ding","year":"2016","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0025","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3389\/fpls.2015.00677","article-title":"Expression profiling and functional analysis reveals that TOR is a key player in regulating photosynthesis and phytohormone signaling pathways in Arabidopsis","volume":"6","author":"Dong","year":"2015","journal-title":"Frontiers in Plant Science"},{"key":"2021070808401363600_CIT0026","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41467-017-01224-w","article-title":"Sulfur availability regulates plant growth via glucose-TOR signaling","volume":"8","author":"Dong","year":"2017","journal-title":"Nature Communications"},{"key":"2021070808401363600_CIT0027","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.tplants.2015.11.001","article-title":"Molecular insights into the enigmatic metabolic regulator, SnRK1","volume":"21","author":"Emanuelle","year":"2016","journal-title":"Trends in Plant Science"},{"key":"2021070808401363600_CIT0028","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1094\/MPMI.2004.17.4.343","article-title":"Proline accumulation and AtP5CS2 gene activation are induced by plant-pathogen incompatible interactions in Arabidopsis","volume":"17","author":"Fabro","year":"2004","journal-title":"Molecular Plant-Microbe Interactions"},{"key":"2021070808401363600_CIT0029","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fpls.2012.00222","article-title":"Flavonoids: biosynthesis, biological functions, and biotechnological applications","volume":"3","author":"Falcone Ferreyra","year":"2012","journal-title":"Frontiers in Plant Science"},{"key":"2021070808401363600_CIT0030","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1104\/pp.19.01214","article-title":"Target of Rapamycin signaling in plant stress responses","volume":"182","author":"Fu","year":"2020","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0031","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1093\/jxb\/erx013","article-title":"How do plants sense their nitrogen status?","volume":"68","author":"Gent","year":"2017","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0032","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/tpj.13538","article-title":"Disruptions in valine degradation affect seed development and germination in Arabidopsis","volume":"90","author":"Gipson","year":"2017","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0033","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1093\/jxb\/erz225","article-title":"Signaling by hydrogen sulfide and cyanide through post-translational modification","volume":"70","author":"Gotor","year":"2019","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0034","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/nph.17034","article-title":"Structural insights into long-distance signal transduction pathways mediated by plant glutamate receptor-like channels","volume":"229","author":"Grenzi","year":"2021","journal-title":"New Phytologist"},{"key":"2021070808401363600_CIT0035","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.molp.2015.05.005","article-title":"Regulation of photosynthesis during abiotic stress-induced photoinhibition","volume":"8","author":"Gururani","year":"2015","journal-title":"Molecular Plant"},{"key":"2021070808401363600_CIT0036","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.arplant.57.032905.105228","article-title":"Biology and biochemistry of glucosinolates","volume":"57","author":"Halkier","year":"2006","journal-title":"Annual Review of Plant Biology"},{"key":"2021070808401363600_CIT0037","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/tpj.14037","article-title":"l-lysine metabolism to N-hydroxypipecolic acid: an integral immune-activating pathway in plants","volume":"96","author":"Hartmann","year":"2018","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0038","volume-title":"Shikimic acid: metabolism and metabolites","author":"Haslam","year":"1993"},{"key":"2021070808401363600_CIT0039","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1105\/tpc.107.056747","article-title":"Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis","volume":"20","author":"Heeg","year":"2008","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0040","first-page":"385","article-title":"Estimating the number of protein molecules in a plant cell: protein and amino acid homeostasis during drought","volume":"185","author":"Heinemann","year":"2021","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0041","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.molp.2015.09.005","article-title":"Amino acid catabolism in plants","volume":"8","author":"Hildebrandt","year":"2015","journal-title":"Molecular Plant"},{"key":"2021070808401363600_CIT0042","first-page":"1363","article-title":"Vacuolar protein degradation via autophagy provides substrates to amino acid catabolic pathways as an adaptive response to sugar starvation in Arabidopsis thaliana","volume":"59","author":"Hirota","year":"2018","journal-title":"Plant & Cell Physiology"},{"key":"2021070808401363600_CIT0043","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1105\/tpc.19.00066","article-title":"Genetic analyses of the Arabidopsis ATG1 kinase complex reveal both kinase-dependent and independent autophagic routes during fixed-carbon starvation","volume":"31","author":"Huang","year":"2019","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0044","doi-asserted-by":"crossref","first-page":"R154","DOI":"10.1016\/j.cub.2005.02.037","article-title":"Neurotransmitters","volume":"15","author":"Hyman","year":"2005","journal-title":"Current Biology"},{"key":"2021070808401363600_CIT0045","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1105\/tpc.105.035162","article-title":"The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation","volume":"17","author":"Ishizaki","year":"2005","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0046","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1365-313X.2006.02826.x","article-title":"The mitochondrial electron transfer flavoprotein complex is essential for survival of Arabidopsis in extended darkness","volume":"47","author":"Ishizaki","year":"2006","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0047","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1104\/pp.113.215632","article-title":"Autophagy contributes to nighttime energy availability for growth in Arabidopsis","volume":"161","author":"Izumi","year":"2013","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0048","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/jxb\/erz107","article-title":"Evolution of TOR\u2013SnRK dynamics in green plants and its integration with phytohormone signaling networks","volume":"70","author":"Jamsheer K","year":"2019","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0049","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41556-018-0205-1","article-title":"mTOR as a central hub of nutrient signalling and cell growth","volume":"21","author":"Kim","year":"2019","journal-title":"Nature Cell Biology"},{"key":"2021070808401363600_CIT0050","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/tpj.13955","article-title":"Metabolic reconstructions identify plant 3-methylglutaconyl-CoA hydratase that is crucial for branched-chain amino acid catabolism in mitochondria","volume":"95","author":"Latimer","year":"2018","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0051","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1105\/tpc.20.00766","article-title":"Abscisic acid-triggered persulfidation of cysteine protease ATG4 mediates regulation of autophagy by sulfide","volume":"32","author":"Laureano-Mar\u00edn","year":"2020","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0052","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1105\/tpc.110.082867","article-title":"Coordinated gene networks regulating Arabidopsis plant metabolism in response to various stresses and nutritional cues","volume":"23","author":"Less","year":"2011","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0053","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1104\/pp.108.115733","article-title":"Principal transcriptional programs regulating plant amino acid metabolism in response to abiotic stresses","volume":"147","author":"Less","year":"2008","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0054","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1073\/pnas.1618782114","article-title":"Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes","volume":"114","author":"Li","year":"2017","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2021070808401363600_CIT0055","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1105\/tpc.110.079392","article-title":"Amino acid homeostasis modulates salicylic acid-associated redox status and defense responses in Arabidopsis","volume":"22","author":"Liu","year":"2010","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0056","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-arplant-042811-105441","article-title":"Autophagy: pathways for self-eating in plant cells","volume":"63","author":"Liu","year":"2012","journal-title":"Annual Review of Plant Biology"},{"key":"2021070808401363600_CIT0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2021.03.022","article-title":"Diverse nitrogen signals activate convergent ROP2-TOR signaling in Arabidopsis","author":"Liu","year":"2021","journal-title":"Developmental Cell doi:"},{"key":"2021070808401363600_CIT0058","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00425-009-1001-8","article-title":"Gene expression profiling of ozone-treated Arabidopsis abi1td insertional mutant: protein phosphatase 2C ABI1 modulates biosynthesis ratio of ABA and ethylene","volume":"230","author":"Ludwik\u00f3w","year":"2009","journal-title":"Planta"},{"key":"2021070808401363600_CIT0059","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1093\/jxb\/erz066","article-title":"SnRK1 and TOR: modulating growth\u2013defense trade-offs in plant stress responses","volume":"70","author":"Margalha","year":"2019","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0060","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1126\/science.1201101","article-title":"Glutamate receptor-like genes form Ca2+ channels in pollen tubes and are regulated by pistil","volume":"332","author":"Michard","year":"2011","journal-title":"Science"},{"key":"2021070808401363600_CIT0061","doi-asserted-by":"crossref","first-page":"107316","DOI":"10.1016\/j.biotechadv.2018.11.005","article-title":"Flavonoid biosynthetic pathways in plants: versatile targets for metabolic engineering","volume":"38","author":"Nabavi","year":"2020","journal-title":"Biotechnology Advances"},{"key":"2021070808401363600_CIT0062","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-313X.1999.00438.x","article-title":"Biological functions of proline in morphogenesis and osmotolerance revealed in antisense transgenic Arabidopsis thaliana","volume":"18","author":"Nanjo","year":"1999","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0063","doi-asserted-by":"crossref","first-page":"31697","DOI":"10.1038\/srep31697","article-title":"Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation","volume":"6","author":"Nukarinen","year":"2016","journal-title":"Scientific Reports"},{"key":"2021070808401363600_CIT0064","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1105\/tpc.19.00157","article-title":"Metabolite regulatory interactions control plant respiratory metabolism via Target of Rapamycin (TOR) kinase activation","volume":"32","author":"O\u2019Leary","year":"2020","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0065","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1046\/j.1365-313X.2003.01774.x","article-title":"Monitoring expression profiles of Arabidopsis gene expression during rehydration process after dehydration using ca. 7000 full-length cDNA microarray","volume":"34","author":"Oono","year":"2003","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0066","doi-asserted-by":"crossref","DOI":"10.1093\/jxb\/eraa603","article-title":"The tip of the iceberg: emerging roles of TORC1 and its regulation in plant cells","author":"Pacheco","year":"2021","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0067","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cub.2011.12.015","article-title":"The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition","volume":"22","author":"Pajerowska-Mukhtar","year":"2012","journal-title":"Current Biology"},{"key":"2021070808401363600_CIT0068","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/1471-2164-14-216","article-title":"CAMTA 1 regulates drought responses in Arabidopsis thaliana","volume":"14","author":"Pandey","year":"2013","journal-title":"BMC Genomics"},{"key":"2021070808401363600_CIT0069","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1105\/tpc.17.00414","article-title":"Snf1-RELATED KINASE1-controlled C\/S1-bZIP signaling activates alternative mitochondrial metabolic pathways to ensure plant survival in extended darkness","volume":"30","author":"Pedrotti","year":"2018","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0070","first-page":"1807","article-title":"The impact of the branched-chain ketoacid dehydrogenase complex on amino acid homeostasis in Arabidopsis","volume":"169","author":"Peng","year":"2015","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0071","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1105\/tpc.108.061374","article-title":"Transgenic Arabidopsis plants expressing the type 1 inositol 5-phosphatase exhibit increased drought tolerance and altered abscisic acid signaling","volume":"20","author":"Perera","year":"2008","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0072","doi-asserted-by":"crossref","first-page":"e17023","DOI":"10.7554\/eLife.17023","article-title":"Integration of light and metabolic signals for stem cell activation at the shoot apical meristem","volume":"5","author":"Pfeiffer","year":"2016","journal-title":"eLife"},{"key":"2021070808401363600_CIT0073","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1105\/tpc.021642","article-title":"Overexpression of GLUTAMINE DUMPER1 leads to hypersecretion of glutamine from hydathodes of Arabidopsis leaves","volume":"16","author":"Pilot","year":"2004","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0074","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/pce.12682","article-title":"The influence of alternative pathways of respiration that utilize branched-chain amino acids following water shortage in Arabidopsis","volume":"39","author":"Pires","year":"2016","journal-title":"Plant, Cell & Environment"},{"key":"2021070808401363600_CIT0075","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.3389\/fpls.2019.01743","article-title":"Signaling role of glutamate in plants","volume":"10","author":"Qiu","year":"2020","journal-title":"Frontiers in Plant Science"},{"key":"2021070808401363600_CIT0076","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/plants8010021","article-title":"Sulfate-induced stomata closure requires the canonical ABA signal transduction machinery","volume":"8","author":"Rajab","year":"2019","journal-title":"Plants"},{"key":"2021070808401363600_CIT0077","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1105\/tpc.18.00500","article-title":"Default activation and nuclear translocation of the plant cellular energy sensor SnRK1 regulate metabolic stress responses and development","volume":"31","author":"Ramon","year":"2019","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0078","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1105\/tpc.113.114066","article-title":"ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis","volume":"25","author":"Rodrigues","year":"2013","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0079","doi-asserted-by":"crossref","first-page":"110220","DOI":"10.1016\/j.plantsci.2019.110220","article-title":"TOR and SnRK1 signaling pathways in plant response to abiotic stresses: do they always act according to the \u201cyin-yang\u201d model?","volume":"288","author":"Rodriguez","year":"2019","journal-title":"Plant Science"},{"key":"2021070808401363600_CIT0080","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1093\/jxb\/erz108","article-title":"Target of Rapamycin kinase: central regulatory hub for plant growth and metabolism","volume":"70","author":"Ryabova","year":"2019","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0081","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.plaphy.2013.02.001","article-title":"The flavonoid biosynthetic pathway in Arabidopsis: structural and genetic diversity","volume":"72","author":"Saito","year":"2013","journal-title":"Plant Physiology and Biochemistry"},{"key":"2021070808401363600_CIT0082","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1038\/s41467-019-12002-1","article-title":"Auxin-sensitive Aux\/IAA proteins mediate drought tolerance in Arabidopsis by regulating glucosinolate levels","volume":"10","author":"Salehin","year":"2019","journal-title":"Nature Communications"},{"key":"2021070808401363600_CIT0083","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/pcp\/pch036","article-title":"A novel subgroup of bZIP proteins functions as transcriptional activators in hypoosmolarity-responsive expression of the ProDH gene in Arabidopsis","volume":"45","author":"Satoh","year":"2004","journal-title":"Plant & Cell Physiology"},{"key":"2021070808401363600_CIT0084","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/emboj.2013.61","article-title":"TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h","volume":"32","author":"Schepetilnikov","year":"2013","journal-title":"The EMBO Journal"},{"key":"2021070808401363600_CIT0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1104\/pp.17.00649","article-title":"3-Hydroxyisobutyrate dehydrogenase is involved in both, valine and isoleucine degradation in Arabidopsis thaliana","volume":"175","author":"Schertl","year":"2017","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0086","first-page":"105","article-title":"Balancing growth and defense.","volume-title":"Protein kinases and stress signaling in plants: functional genomic perspective","author":"Sharma","year":"2021"},{"key":"2021070808401363600_CIT0087","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1105\/tpc.19.00826","article-title":"Persulfidation-based modification of cysteine desulfhydrase and the NADPH oxidase RBOHD controls guard cell abscisic acid signaling","volume":"32","author":"Shen","year":"2020","journal-title":"The Plant Cell"},{"key":"2021070808401363600_CIT0088","doi-asserted-by":"crossref","first-page":"dev160887","DOI":"10.1242\/dev.160887","article-title":"TOR signaling in plants: conservation and innovation","volume":"145","author":"Shi","year":"2018","journal-title":"Development"},{"key":"2021070808401363600_CIT0089","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tplants.2019.02.001","article-title":"Linking autophagy to abiotic and biotic stress responses","volume":"24","author":"Signorelli","year":"2019","journal-title":"Trends in Plant Science"},{"key":"2021070808401363600_CIT0090","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11157-015-9372-8","article-title":"Roles of osmoprotectants in improving salinity and drought tolerance in plants: a review","volume":"14","author":"Singh","year":"2015","journal-title":"Reviews in Environmental Science and Bio\/Technology"},{"key":"2021070808401363600_CIT0091","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1104\/pp.18.00421","article-title":"Sulfur partitioning between glutathione and protein synthesis determines plant growth","volume":"177","author":"Speiser","year":"2018","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0092","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tplants.2009.11.009","article-title":"Proline: a multifunctional amino acid","volume":"15","author":"Szabados","year":"2010","journal-title":"Trends in Plant Science"},{"key":"2021070808401363600_CIT0093","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-313X.2007.03318.x","article-title":"Duplicated P5CS genes of Arabidopsis play distinct roles in stress regulation and developmental control of proline biosynthesis","volume":"53","author":"Sz\u00e9kely","year":"2008","journal-title":"The Plant Journal"},{"key":"2021070808401363600_CIT0094","doi-asserted-by":"crossref","first-page":"180162","DOI":"10.1098\/rsob.180162","article-title":"Autophagy in crop plants: what\u2019s new beyond Arabidopsis?","volume":"8","author":"Tang","year":"2018","journal-title":"Open Biology"},{"key":"2021070808401363600_CIT0095","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1038\/s41467-020-16815-3","article-title":"An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism","volume":"11","author":"Thompson","year":"2020","journal-title":"Nature Communications"},{"key":"2021070808401363600_CIT0096","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1104\/pp.107.115592","article-title":"Global transcript levels respond to small changes of the carbon status during progressive exhaustion of carbohydrates in Arabidopsis rosettes","volume":"146","author":"Usadel","year":"2008","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0097","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41477-019-0378-z","article-title":"Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase","volume":"5","author":"Van Leene","year":"2019","journal-title":"Nature Plants"},{"key":"2021070808401363600_CIT0098","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.molcel.2017.12.002","article-title":"Reciprocal regulation of the TOR kinase and ABA receptor balances plant growth and stress response","volume":"69","author":"Wang","year":"2018","journal-title":"Molecular Cell"},{"key":"2021070808401363600_CIT0099","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1038\/sj.emboj.7601206","article-title":"Combinatorial control of Arabidopsis proline dehydrogenase transcription by specific heterodimerisation of bZIP transcription factors","volume":"25","author":"Weltmeier","year":"2006","journal-title":"The EMBO Journal"},{"key":"2021070808401363600_CIT0100","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1093\/jxb\/erz028","article-title":"Integration of nutrient, energy, light, and hormone signalling via TOR in plants","volume":"70","author":"Wu","year":"2019","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0101","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1093\/jxb\/ery153","article-title":"Comparing plant and animal glutamate receptors: common traits but different fates?","volume":"69","author":"Wudick","year":"2018","journal-title":"Journal of Experimental Botany"},{"key":"2021070808401363600_CIT0102","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1002\/1873-3468.12852","article-title":"Redox state-dependent modulation of plant SnRK1 kinase activity differs from AMPK regulation in animals","volume":"591","author":"Wurzinger","year":"2017","journal-title":"FEBS Letters"},{"key":"2021070808401363600_CIT0103","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1104\/pp.17.01404","article-title":"The SnRK1 kinase as central mediator of energy signaling between different organelles","volume":"176","author":"Wurzinger","year":"2018","journal-title":"Plant Physiology"},{"key":"2021070808401363600_CIT0104","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature12030","article-title":"Glucose\u2013TOR signalling reprograms the transcriptome and activates meristems","volume":"496","author":"Xiong","year":"2013","journal-title":"Nature"},{"key":"2021070808401363600_CIT0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.molp.2021.03.007","article-title":"Hydrogen sulfide-linked persulfidation of ABI4 controls ABA responses through the transactivation of MAPKKK18 in Arabidopsis","author":"Zhou","year":"2021","journal-title":"Molecular Plant"}],"container-title":["Journal of Experimental Botany"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jxb\/advance-article-pdf\/doi\/10.1093\/jxb\/erab182\/38390799\/erab182.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jxb\/article-pdf\/72\/13\/4634\/38806956\/erab182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jxb\/article-pdf\/72\/13\/4634\/38806956\/erab182.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T13:30:31Z","timestamp":1625751031000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jxb\/article\/72\/13\/4634\/6276456"}},"subtitle":[],"editor":[{"given":"Karl-Josef","family":"Dietz","sequence":"additional","affiliation":[{"name":"Bielefeld University, Germany"}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,16]]},"references-count":105,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,5,16]]},"published-print":{"date-parts":[[2021,6,22]]}},"URL":"https:\/\/doi.org\/10.1093\/jxb\/erab182","relation":{},"ISSN":["0022-0957","1460-2431"],"issn-type":[{"value":"0022-0957","type":"print"},{"value":"1460-2431","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6,22]]},"published":{"date-parts":[[2021,5,16]]}}}