{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:26:44Z","timestamp":1775982404633,"version":"3.50.1"},"reference-count":138,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["BIO2017-87828-C2-1-P"],"award-info":[{"award-number":["BIO2017-87828-C2-1-P"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Copper and iron proteins have a wide range of functions in living organisms. Metal assembly into metalloproteins is a complex process, where mismetalation is detrimental and energy consuming to cells. Under metal deficiency, metal distribution is expected to reach a metalation ranking, prioritizing essential versus dispensable metalloproteins, while avoiding interference with other metals and protecting metal-sensitive processes. In this review, we propose that post-transcriptional modulators of metalloprotein mRNA (ModMeR) are good candidates in metal prioritization under metal-limited conditions. ModMeR target high quota or redundant metalloproteins and, by adjusting their synthesis, ModMeR act as internal metal distribution valves. Inappropriate metalation of ModMeR targets could compete with metal delivery to essential metalloproteins and interfere with metal-sensitive processes, such as chloroplastic photosynthesis and mitochondrial respiration. Regulation of ModMeR targets could increase or decrease the metal flow through interconnected pathways in cellular metal distribution, helping to achieve adequate differential metal requirements. Here, we describe and compare ModMeR that function in response to copper and iron deficiencies. Specifically, we describe copper-miRNAs from Arabidopsis thaliana and diverse iron ModMeR from yeast, mammals, and bacteria under copper and iron deficiencies, as well as the influence of oxidative stress. Putative functions derived from their role as ModMeR are also discussed.<\/jats:p>","DOI":"10.1093\/jxb\/erab521","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T20:17:50Z","timestamp":1637871470000},"page":"1735-1750","source":"Crossref","is-referenced-by-count":6,"title":["The role of post-transcriptional modulators of metalloproteins in response to metal deficiencies"],"prefix":"10.1093","volume":"73","author":[{"given":"Ana","family":"Perea-Garc\u00eda","sequence":"first","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular and Institut Universitari de Biotecnologia i Biomedicina (BIOTECMED), Universitat de Val\u00e8ncia, Burjassot, Valencia, Spain"},{"name":"Departamento de Biotecnolog\u00eda, Instituto de Agroqu\u00edmica y Tecnolog\u00eda de Alimentos (IATA), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Paterna, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Puig","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, Instituto de Agroqu\u00edmica y Tecnolog\u00eda de Alimentos (IATA), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Paterna, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-2536","authenticated-orcid":false,"given":"Lola","family":"Pe\u00f1arrubia","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular and Institut Universitari de Biotecnologia i Biomedicina (BIOTECMED), Universitat de Val\u00e8ncia, Burjassot, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"2022031615000853400_CIT0001","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1105\/tpc.104.030452","article-title":"Two P-type ATPases are required for copper delivery in Arabidopsis thaliana chloroplasts.","volume":"17","author":"Abdel-Ghany","year":"2005","journal-title":"The Plant Cell"},{"key":"2022031615000853400_CIT0002","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3389\/fpls.2015.01250","article-title":"Copper delivery to chloroplast proteins and its regulation.","volume":"6","author":"Aguirre","year":"2016","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0003","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jplph.2018.03.014","article-title":"SPL7 locally regulates copper-homeostasis-related genes in Arabidopsis.","volume":"224\u2013225","author":"Araki","year":"2018","journal-title":"Journal of Plant Physiology"},{"key":"2022031615000853400_CIT0004","doi-asserted-by":"crossref","first-page":"110808","DOI":"10.1016\/j.plantsci.2020.110808","article-title":"PAP\/SAL1 retrograde signaling pathway modulates iron deficiency response in alkaline soils.","volume":"304","author":"Balparda","year":"2021","journal-title":"Plant Science"},{"key":"2022031615000853400_CIT0005","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cmet.2012.10.001","article-title":"mTOR regulates cellular iron homeostasis through tristetraprolin.","volume":"16","author":"Bayeva","year":"2012","journal-title":"Cell Metabolism"},{"key":"2022031615000853400_CIT0006","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/jxb\/erx286","article-title":"The endoplasmic reticulum is a hub to sort proteins toward unconventional traffic pathways and endosymbiotic organelles.","volume":"69","author":"Bellucci","year":"2017","journal-title":"Journal of Experimental Botany"},{"key":"2022031615000853400_CIT0007","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1105\/tpc.111.090431","article-title":"Transcriptome sequencing identifies SPL7-regulated copper acquisition genes FRO4\/FRO5 and the copper dependence of iron homeostasis in Arabidopsis.","volume":"24","author":"Bernal","year":"2012","journal-title":"The Plant Cell"},{"key":"2022031615000853400_CIT0008","doi-asserted-by":"crossref","first-page":"28129","DOI":"10.1074\/jbc.R114.592618","article-title":"Lysosome-related organelles as mediators of metal homeostasis.","volume":"289","author":"Blaby-Haas","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"2022031615000853400_CIT0009","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrm4085","article-title":"The expanding world of small RNAs in plants.","volume":"16","author":"Borges","year":"2015","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"2022031615000853400_CIT0010","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2229-10-64","article-title":"Phloem small RNAs, nutrient stress responses, and systemic mobility.","volume":"10","author":"Buhtz","year":"2010","journal-title":"BMC Plant Biology"},{"key":"2022031615000853400_CIT0011","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1469-8137.2009.02846.x","article-title":"Copper homeostasis.","volume":"182","author":"Burkhead","year":"2009","journal-title":"New Phytologist"},{"key":"2022031615000853400_CIT0012","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1038\/s41598-018-38005-4","article-title":"Copper transporter COPT5 participates in the crosstalk between vacuolar copper and iron pools mobilisation.","volume":"9","author":"Carri\u00f3-Segu\u00ed","year":"2019","journal-title":"Scientific Reports"},{"key":"2022031615000853400_CIT0013","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fpls.2019.00324","article-title":"The altered expression of microRNA408 influences the Arabidopsis response to iron deficiency.","volume":"10","author":"Carri\u00f3-Segu\u00ed","year":"2019","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0014","doi-asserted-by":"crossref","first-page":"e17272","DOI":"10.1371\/journal.pone.0017272","article-title":"Heat shock response in yeast involves changes in both transcription rates and mRNA stabilities.","volume":"6","author":"Castells-Roca","year":"2011","journal-title":"PLoS One"},{"key":"2022031615000853400_CIT0015","doi-asserted-by":"crossref","first-page":"e0148204","DOI":"10.1371\/journal.pone.0148204","article-title":"Cth2 protein mediates early adaptation of yeast cells to oxidative stress conditions.","volume":"11","author":"Castells-Roca","year":"2016","journal-title":"PLoS One"},{"key":"2022031615000853400_CIT0016","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1172\/JCI44883","article-title":"The liver-specific microRNA miR122 controls systemic iron homeostasis in mice.","volume":"121","author":"Castoldi","year":"2011","journal-title":"Journal of Clinical Investigation"},{"key":"2022031615000853400_CIT0017","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1093\/jxb\/erv060","article-title":"Arabidopsis C3H14 and C3H15 have overlapping roles in the regulation of secondary wall thickening and anther development.","volume":"66","author":"Chai","year":"2015","journal-title":"Journal of Experimental Botany"},{"key":"2022031615000853400_CIT0018","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/9781683670247.ch16","article-title":"Bacterial iron homeostasis regulation by sRNAs","volume-title":"Regulating with RNA in bacteria and archaea","author":"Chareyre","year":"2018"},{"key":"2022031615000853400_CIT0019","first-page":"441","article-title":"ASCORBATE PEROXIDASE6 delays the onset of age-dependent leaf senescence.","volume":"185","author":"Chen","year":"2021","journal-title":"Plant Physiology"},{"key":"2022031615000853400_CIT0020","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-arplant-050718-100221","article-title":"Modeling plant metabolism: from network reconstruction to mechanistic models.","volume":"71","author":"Clark","year":"2020","journal-title":"Annual Review of Plant Biology"},{"key":"2022031615000853400_CIT0021","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1111\/pce.13627","article-title":"Metal ligands in micronutrient acquisition and homeostasis.","volume":"42","author":"Clemens","year":"2019","journal-title":"Plant, Cell & Environment"},{"key":"2022031615000853400_CIT0022","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1105\/tpc.104.024315","article-title":"The essential basic helix\u2013loop\u2013helix protein FIT1 is required for the iron deficiency response.","volume":"16","author":"Colangelo","year":"2004","journal-title":"The Plant Cell"},{"key":"2022031615000853400_CIT0023","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1039\/C7MT00136C","article-title":"Iron homeostasis in plants\u2014a brief overview.","volume":"9","author":"Connorton","year":"2017","journal-title":"Metallomics"},{"key":"2022031615000853400_CIT0024","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1105\/tpc.110.082784","article-title":"Evolution and functional diversification of MIRNA genes.","volume":"23","author":"Cuperus","year":"2011","journal-title":"The Plant Cell"},{"key":"2022031615000853400_CIT0025","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/nph.14364","article-title":"New routes for plant iron mining.","volume":"214","author":"Curie","year":"2017","journal-title":"New Phytologist"},{"key":"2022031615000853400_CIT0026","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.3390\/nu5072611","article-title":"Influence of microRNA on the maintenance of human iron metabolism.","volume":"5","author":"Davis","year":"2013","journal-title":"Nutrients"},{"key":"2022031615000853400_CIT0027","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1021\/acs.jafc.9b07468","article-title":"Emerging roles of microRNAs in plant heavy metal tolerance and homeostasis.","volume":"68","author":"Ding","year":"2020","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"2022031615000853400_CIT0028","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11103-008-9329-1","article-title":"Sucrose induction of Arabidopsis miR398 represses two Cu\/Zn superoxide dismutases.","volume":"67","author":"Dugas","year":"2008","journal-title":"Plant Molecular Biology"},{"key":"2022031615000853400_CIT0029","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.str.2005.09.009","article-title":"Crystal structure of human iron regulatory protein 1 as cytosolic aconitase.","volume":"14","author":"Dupuy","year":"2006","journal-title":"Structure"},{"key":"2022031615000853400_CIT0030","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.devcel.2018.11.046","article-title":"Chloroplast-to-nucleus signaling regulates microRNA biogenesis in Arabidopsis.","volume":"48","author":"Fang","year":"2019","journal-title":"Developmental Cell"},{"key":"2022031615000853400_CIT0031","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.plaphy.2019.04.039","article-title":"Acquiring control: the evolution of ROS-induced oxidative stress and redox signaling pathways in plant stress responses.","volume":"141","author":"Farooq","year":"2019","journal-title":"Plant Physiology and Biochemistry"},{"key":"2022031615000853400_CIT0032","doi-asserted-by":"crossref","first-page":"15454","DOI":"10.1074\/jbc.RA120.014814","article-title":"Ferric uptake regulator (Fur) reversibly binds a [2Fe\u20132S] cluster to sense intracellular iron homeostasis in Escherichia coli.","volume":"295","author":"Fontenot","year":"2020","journal-title":"Journal of Biological Chemistry"},{"key":"2022031615000853400_CIT0033","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/jxb\/eraa556","article-title":"Transcriptional integration of plant responses to iron availability.","volume":"72","author":"Gao","year":"2021","journal-title":"Journal of Experimental Botany"},{"key":"2022031615000853400_CIT0034","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fpls.2019.00006","article-title":"the transcriptional control of iron homeostasis in plants: a tale of bHLH transcription factors?","volume":"10","author":"Gao","year":"2019","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.mito.2014.02.011","article-title":"Mitochondria and copper homeostasis in plants.","volume":"19 Pt B","author":"Garcia","year":"2014","journal-title":"Mitochondrion"},{"key":"2022031615000853400_CIT0036","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1365-313X.2010.04472.x","article-title":"The intracellular Arabidopsis COPT5 transport protein is required for photosynthetic electron transport under severe copper deficiency.","volume":"65","author":"Garcia-Molina","year":"2011","journal-title":"The Plant Journal"},{"key":"2022031615000853400_CIT0037","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1093\/pcp\/pct088","article-title":"The Arabidopsis COPT6 transport protein functions in copper distribution under copper-deficient conditions.","volume":"54","author":"Garcia-Molina","year":"2013","journal-title":"Plant & Cell Physiology"},{"key":"2022031615000853400_CIT0038","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/tpj.14887","article-title":"Systems biology of responses to simultaneous copper and iron deficiency in Arabidopsis.","volume":"103","author":"Garcia-Molina","year":"2020","journal-title":"The Plant Journal"},{"key":"2022031615000853400_CIT0039","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12870-014-0231-5","article-title":"Functional characterisation of Arabidopsis SPL7 conserved protein domains suggests novel regulatory mechanisms in the Cu deficiency response.","volume":"14","author":"Garcia-Molina","year":"2014","journal-title":"BMC Plant Biology"},{"key":"2022031615000853400_CIT0040","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3389\/fpls.2015.00716","article-title":"Local and systemic signaling of iron status and its interactions with homeostasis of other essential elements.","volume":"6","author":"Gayomba","year":"2015","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0041","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/tpj.12169","article-title":"Heat stress induction of miR398 triggers a regulatory loop that is critical for thermotolerance in Arabidopsis.","volume":"74","author":"Guan","year":"2013","journal-title":"The Plant Journal"},{"key":"2022031615000853400_CIT0042","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of mammalian iron metabolism.","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"key":"2022031615000853400_CIT0043","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1242\/dev.063511","article-title":"The control of developmental phase transitions in plants.","volume":"138","author":"Huijser","year":"2011","journal-title":"Development"},{"key":"2022031615000853400_CIT0044","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fpls.2013.00348","article-title":"Mitochondrial iron transport and homeostasis in plants.","volume":"4","author":"Jain","year":"2013","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0045","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pbi.2017.06.014","article-title":"Directing iron transport in dicots: regulation of iron acquisition and translocation.","volume":"39","author":"Jeong","year":"2017","journal-title":"Current Opinion in Plant Biology"},{"key":"2022031615000853400_CIT0046","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.arplant.57.032905.105218","article-title":"MicroRNAs and their regulatory roles in plants.","volume":"57","author":"Jones-Rhoades","year":"2006","journal-title":"Annual Review of Plant Biology"},{"key":"2022031615000853400_CIT0047","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1039\/C8MT00287H","article-title":"New aspects of iron\u2013copper crosstalk uncovered by transcriptomic characterization of Col-0 and the copper uptake mutant spl7 in Arabidopsis thaliana.","volume":"10","author":"Kastoori Ramamurthy","year":"2018","journal-title":"Metallomics"},{"key":"2022031615000853400_CIT0048","doi-asserted-by":"crossref","first-page":"100866","DOI":"10.1016\/j.mam.2020.100866","article-title":"Basics and principles of cellular and systemic iron homeostasis.","volume":"75","author":"Katsarou","year":"2020","journal-title":"Molecular Aspects of Medicine"},{"key":"2022031615000853400_CIT0049","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fpls.2013.00145","article-title":"Systemic regulation of mineral homeostasis by micro RNAs.","volume":"4","author":"Kehr","year":"2013","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/nph.15025","article-title":"Long distance RNA movement.","volume":"218","author":"Kehr","year":"2018","journal-title":"New Phytologist"},{"key":"2022031615000853400_CIT0051","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11103-012-9880-7","article-title":"Identification of a cis-acting regulatory motif recognized by MYB46, a master transcriptional regulator of secondary wall biosynthesis.","volume":"78","author":"Kim","year":"2012","journal-title":"Plant Molecular Biology"},{"key":"2022031615000853400_CIT0052","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.freeradbiomed.2018.10.439","article-title":"Iron transport and its regulation in plants.","volume":"133","author":"Kobayashi","year":"2019","journal-title":"Free Radical Biology & Medicine"},{"key":"2022031615000853400_CIT0053","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1038\/ncomms3792","article-title":"Iron-binding haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation.","volume":"4","author":"Kobayashi","year":"2013","journal-title":"Nature Communications"},{"key":"2022031615000853400_CIT0054","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/pcp\/pcz038","article-title":"Understanding the complexity of iron sensing and signaling cascades in plants.","volume":"60","author":"Kobayashi","year":"2019","journal-title":"Plant & Cell Physiology"},{"key":"2022031615000853400_CIT0055","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3390\/cells9051184","article-title":"Closing the gap: membrane contact sites in the regulation of autophagy.","volume":"9","author":"Kohler","year":"2020","journal-title":"Cells"},{"key":"2022031615000853400_CIT0056","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.plaphy.2009.12.008","article-title":"Identification of iron-deficiency responsive microRNA genes and cis-elements in Arabidopsis.","volume":"48","author":"Kong","year":"2010","journal-title":"Plant Physiology and Biochemistry"},{"key":"2022031615000853400_CIT0057","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1039\/d0mt00175a","article-title":"Iron deficiency and the loss of chloroplast iron\u2013sulfur cluster assembly trigger distinct transcriptome changes in Arabidopsis rosettes.","volume":"12","author":"Kroh","year":"2020","journal-title":"Metallomics"},{"key":"2022031615000853400_CIT0058","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1073\/pnas.1422492112","article-title":"Copper economy in Chlamydomonas: prioritized allocation and reallocation of copper to respiration vs. photosynthesis.","volume":"112","author":"Kropat","year":"2015","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2022031615000853400_CIT0059","doi-asserted-by":"crossref","first-page":"18730","DOI":"10.1073\/pnas.0507693102","article-title":"A regulator of nutritional copper signaling in Chlamydomonas is an SBP domain protein that recognizes the GTAC core of copper response element.","volume":"102","author":"Kropat","year":"2005","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2022031615000853400_CIT0060","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1039\/C4MT00164H","article-title":"Iron regulatory proteins and their role in controlling iron metabolism.","volume":"7","author":"K\u00fchn","year":"2015","journal-title":"Metallomics"},{"key":"2022031615000853400_CIT0061","doi-asserted-by":"crossref","first-page":"127810","DOI":"10.1016\/j.chemosphere.2020.127810","article-title":"Copper bioavailability, uptake, toxicity and tolerance in plants: a comprehensive review.","volume":"262","author":"Kumar","year":"2021","journal-title":"Chemosphere"},{"key":"2022031615000853400_CIT0062","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10265-016-0887-z","article-title":"Activity and roles of Arabidopsis thaliana XRN family exoribonucleases in noncoding RNA pathways.","volume":"130","author":"Kurihara","year":"2017","journal-title":"Journal of Plant Research"},{"key":"2022031615000853400_CIT0063","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.biocel.2011.08.016","article-title":"The role of lysosomes in iron metabolism and recycling.","volume":"43","author":"Kurz","year":"2011","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"2022031615000853400_CIT0064","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev-biochem-013118-111540","article-title":"Mechanisms of mitochondrial iron\u2013sulfur protein biogenesis.","volume":"89","author":"Lill","year":"2020","journal-title":"Annual Review of Biochemistry"},{"key":"2022031615000853400_CIT0065","doi-asserted-by":"crossref","first-page":"13938","DOI":"10.1073\/pnas.212448699","article-title":"The tomato fer gene encoding a bHLH protein controls iron-uptake responses in roots.","volume":"99","author":"Ling","year":"2002","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2022031615000853400_CIT0066","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fpls.2016.00178","article-title":"Chloroplast iron transport proteins\u2014function and impact on plant physiology.","volume":"7","author":"L\u00f3pez-Mill\u00e1n","year":"2016","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0067","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/tpj.12999","article-title":"miR408 is involved in abiotic stress responses in Arabidopsis.","volume":"84","author":"Ma","year":"2015","journal-title":"The Plant Journal"},{"key":"2022031615000853400_CIT0068","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/tpj.14369","article-title":"Keep calm and carry on: miRNA biogenesis under stress","volume":"99","author":"Manavella","year":"2019","journal-title":"The Plant Journal"},{"key":"2022031615000853400_CIT0069","volume-title":"Marschner\u2019s mineral nutrition of higher plants","author":"Marschner","year":"2012"},{"key":"2022031615000853400_CIT0070","doi-asserted-by":"crossref","first-page":"15785","DOI":"10.3390\/ijms140815785","article-title":"Post-transcriptional regulation of iron homeostasis in Saccharomyces cerevisiae.","volume":"14","author":"Mart\u00ednez-Pastor","year":"2013","journal-title":"International Journal of Molecular Sciences"},{"key":"2022031615000853400_CIT0071","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11274-017-2215-8","article-title":"Mechanisms of iron sensing and regulation in the yeast Saccharomyces cerevisiae.","volume":"33","author":"Mart\u00ednez-Pastor","year":"2017","journal-title":"World Journal of Microbiology & Biotechnology"},{"key":"2022031615000853400_CIT0072","doi-asserted-by":"crossref","first-page":"118797","DOI":"10.1016\/j.bbamcr.2020.118797","article-title":"Adaptation to iron deficiency in human pathogenic fungi.","volume":"1867","author":"Mart\u00ednez-Pastor","year":"2020","journal-title":"Biochimica et Biophysica Acta"},{"key":"2022031615000853400_CIT0073","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1128\/JB.187.20.6962-6971.2005","article-title":"Effect of RyhB small RNA on global iron use in Escherichia coli.","volume":"187","author":"Mass\u00e9","year":"2005","journal-title":"Journal of Bacteriology"},{"key":"2022031615000853400_CIT0074","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00294-017-0689-4","article-title":"Central roles of iron in the regulation of oxidative stress in the yeast Saccharomyces cerevisiae.","volume":"63","author":"Matsuo","year":"2017","journal-title":"Current Genetics"},{"key":"2022031615000853400_CIT0075","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1093\/jxb\/erz290","article-title":"Keep talking: crosstalk between iron and sulfur networks fine-tunes growth and development to promote survival under iron limitation.","volume":"70","author":"Mendoza-C\u00f3zatl","year":"2019","journal-title":"Journal of Experimental Botany"},{"key":"2022031615000853400_CIT0076","doi-asserted-by":"crossref","first-page":"118822","DOI":"10.1016\/j.bbamcr.2020.118822","article-title":"From economy to luxury: copper homeostasis in Chlamydomonas and other algae.","volume":"1867","author":"Merchant","year":"2020","journal-title":"Biochimica et Biophysica Acta"},{"key":"2022031615000853400_CIT0077","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10142-005-0145-2","article-title":"Plant and animal microRNAs: similarities and differences.","volume":"5","author":"Millar","year":"2005","journal-title":"Functional & Integrative Genomics"},{"key":"2022031615000853400_CIT0078","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3390\/biom10111584","article-title":"Cellular dynamics of transition metal exchange on proteins: a challenge but a bonanza for coordination chemistry.","volume":"10","author":"Moulis","year":"2020","journal-title":"Biomolecules"},{"key":"2022031615000853400_CIT0079","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.nutr.28.061807.155521","article-title":"Systemic iron homeostasis and the iron-responsive element\/iron-regulatory protein (IRE\/IRP) regulatory network.","volume":"28","author":"Muckenthaler","year":"2008","journal-title":"Annual Review of Nutrition"},{"key":"2022031615000853400_CIT0080","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1515\/hsz-2020-0237","article-title":"Glutaredoxins and iron\u2013sulfur protein biogenesis at the interface of redox biology and iron metabolism.","volume":"401","author":"M\u00fchlenhoff","year":"2020","journal-title":"Biological Chemistry"},{"key":"2022031615000853400_CIT0081","doi-asserted-by":"crossref","first-page":"118805","DOI":"10.1016\/j.bbamcr.2020.118805","article-title":"The balancing act of NEET proteins: iron, ROS, calcium and metabolism.","volume":"1867","author":"Nechushtai","year":"2020","journal-title":"Biochimica et Biophysica Acta"},{"key":"2022031615000853400_CIT0082","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1128\/jb.172.4.1930-1938.1990","article-title":"Control of Escherichia coli superoxide dismutase (sodA and sodB) genes by the ferric uptake regulation (fur) locus.","volume":"172","author":"Niederhoffer","year":"1990","journal-title":"Journal of Bacteriology"},{"key":"2022031615000853400_CIT0083","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tplants.2011.03.005","article-title":"Chloroplastic and mitochondrial metal homeostasis.","volume":"16","author":"Nouet","year":"2011","journal-title":"Trends in Plant Science"},{"key":"2022031615000853400_CIT0084","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.mib.2013.07.020","article-title":"Iron sensing and regulation in Saccharomyces cerevisiae: ironing out the mechanistic details.","volume":"16","author":"Outten","year":"2013","journal-title":"Current Opinion in Microbiology"},{"key":"2022031615000853400_CIT0085","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1074\/mcp.M115.048520","article-title":"Post-transcriptional coordination of the Arabidopsis iron deficiency response is partially dependent on the E3 ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2).","volume":"14","author":"Pan","year":"2015","journal-title":"Molecular & Cellular Proteomics"},{"key":"2022031615000853400_CIT0086","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/2211536606666170117160338","article-title":"Small and hungry: microRNAs in micronutrient homeostasis of plants.","volume":"6","author":"Patel","year":"2017","journal-title":"MicroRNA"},{"key":"2022031615000853400_CIT0087","doi-asserted-by":"crossref","first-page":"28527","DOI":"10.1074\/jbc.M804910200","article-title":"The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency.","volume":"283","author":"Pedro-Segura","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"2022031615000853400_CIT0088","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fpls.2015.00255","article-title":"Temporal aspects of copper homeostasis and its crosstalk with hormones.","volume":"6","author":"Pe\u00f1arrubia","year":"2015","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0089","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fpls.2014.00019","article-title":"Vacuolar sequestration capacity and long-distance metal transport in plants.","volume":"5","author":"Peng","year":"2014","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0090","doi-asserted-by":"crossref","first-page":"9547","DOI":"10.3390\/ijms22179547","article-title":"The copper-microRNA pathway is integrated with developmental and environmental stress responses in Arabidopsis thaliana","volume":"22","author":"Perea-Garc\u00eda","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"2022031615000853400_CIT0091","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3389\/fpls.2020.01106","article-title":"Deregulated high affinity copper transport alters iron homeostasis in Arabidopsis.","volume":"11","author":"Perea-Garc\u00eda","year":"2020","journal-title":"Frontiers in Plant Science"},{"key":"2022031615000853400_CIT0092","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1104\/pp.112.212407","article-title":"Arabidopsis copper transport protein COPT2 participates in the cross talk between iron deficiency responses and low-phosphate signaling.","volume":"162","author":"Perea-Garc\u00eda","year":"2013","journal-title":"Plant Physiology"},{"key":"2022031615000853400_CIT0093","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1128\/EC.00354-07","article-title":"Response to iron deprivation in Saccharomyces cerevisiae.","volume":"7","author":"Philpott","year":"2008","journal-title":"Eukaryotic Cell"},{"key":"2022031615000853400_CIT0094","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1469-8137.2011.03869.x","article-title":"Moving copper in plants.","volume":"192","author":"Pilon","year":"2011","journal-title":"New Phytologist"},{"key":"2022031615000853400_CIT0095","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/nph.14244","article-title":"The copper microRNAs.","volume":"213","author":"Pilon","year":"2017","journal-title":"New Phytologist"},{"key":"2022031615000853400_CIT0096","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.pbi.2006.03.007","article-title":"Copper cofactor delivery in plant cells.","volume":"9","author":"Pilon","year":"2006","journal-title":"Current Opinion in Plant Biology"},{"key":"2022031615000853400_CIT0097","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/jxb\/eraa578","article-title":"Iron\u2013sulfur proteins in plant mitochondria: roles and maturation.","volume":"72","author":"Przybyla-Toscano","year":"2021","journal-title":"Journal of Experimental Botany"},{"key":"2022031615000853400_CIT0098","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-3040.2007.01642.x","article-title":"Copper and iron homeostasis in Arabidopsis: responses to metal deficiencies, interactions and biotechnological applications.","volume":"30","author":"Puig","year":"2007","journal-title":"Plant, Cell & Environment"},{"key":"2022031615000853400_CIT0099","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cell.2004.11.032","article-title":"Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.","volume":"120","author":"Puig","year":"2005","journal-title":"Cell"},{"key":"2022031615000853400_CIT0100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pbi.2009.04.008","article-title":"Placing metal micronutrients in context: transport and distribution in plants.","volume":"12","author":"Puig","year":"2009","journal-title":"Current Opinion in Plant Biology"},{"key":"2022031615000853400_CIT0101","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cmet.2008.04.010","article-title":"Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency.","volume":"7","author":"Puig","year":"2008","journal-title":"Cell Metabolism"},{"key":"2022031615000853400_CIT0102","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2016.23","article-title":"Mitonuclear communication in homeostasis and stress.","volume":"17","author":"Quir\u00f3s","year":"2016","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"2022031615000853400_CIT0103","doi-asserted-by":"crossref","first-page":"582830","DOI":"10.3389\/fmicb.2020.582830","article-title":"Iron regulatory mechanisms in Saccharomyces cerevisiae.","volume":"11","author":"Ramos-Alonso","year":"2020","journal-title":"Frontiers in Microbiology"},{"key":"2022031615000853400_CIT0104","doi-asserted-by":"crossref","first-page":"e1007476","DOI":"10.1371\/journal.pgen.1007476","article-title":"Yeast Cth2 protein represses the translation of ARE-containing mRNAs in response to iron deficiency.","volume":"14","author":"Ramos-Alonso","year":"2018","journal-title":"PLoS Genetics"},{"key":"2022031615000853400_CIT0105","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1039\/C8MT00124C","article-title":"Molecular strategies to increase yeast iron accumulation and resistance.","volume":"10","author":"Ramos-Alonso","year":"2018","journal-title":"Metallomics"},{"key":"2022031615000853400_CIT0106","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1089\/ars.2012.5084","article-title":"Copper and iron homeostasis in plants: the challenges of oxidative stress.","volume":"19","author":"Ravet","year":"2013","journal-title":"Antioxidants & Redox Signaling"},{"key":"2022031615000853400_CIT0107","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/jxb\/erab003","article-title":"All together now: regulation of the iron deficiency response.","volume":"72","author":"Riaz","year":"2021","journal-title":"Journal of Experimental Botany"},{"key":"2022031615000853400_CIT0108","doi-asserted-by":"crossref","first-page":"e01694","DOI":"10.1128\/mBio.01694-18","article-title":"Phosphorylation and proteasome recognition of the mRNA-binding protein Cth2 facilitates yeast adaptation to iron deficiency","volume":"9","author":"Romero","year":"2018","journal-title":"mBio"},{"key":"2022031615000853400_CIT0109","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1126\/science.1176326","article-title":"An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.","volume":"326","author":"Salahudeen","year":"2009","journal-title":"Science"},{"key":"2022031615000853400_CIT0110","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.molcel.2011.09.021","article-title":"Regulation of ribonucleotide reductase in response to iron deficiency.","volume":"44","author":"Sanvisens","year":"2011","journal-title":"Molecular Cell"},{"key":"2022031615000853400_CIT0111","doi-asserted-by":"crossref","first-page":"E6291","DOI":"10.1073\/pnas.1804701115","article-title":"mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function.","volume":"115","author":"Sato","year":"2018","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2022031615000853400_CIT0112","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1104\/pp.114.250837","article-title":"Iron-binding E3 ligase mediates iron response in plants by targeting basic helix\u2013loop\u2013helix transcription factors.","volume":"167","author":"Selote","year":"2015","journal-title":"Plant Physiology"},{"key":"2022031615000853400_CIT0113","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/plants8060141","article-title":"Conserved Cu-microRNAs in Arabidopsis thaliana function in copper economy under deficiency.","volume":"8","author":"Shahbaz","year":"2019","journal-title":"Plants"},{"key":"2022031615000853400_CIT0114","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s12072-012-9348-5","article-title":"Longitudinal analysis of serum miR-122 in a rat model of Wilson\u2019s disease.","volume":"6","author":"Siaj","year":"2012","journal-title":"Hepatology International"},{"key":"2022031615000853400_CIT0115","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-arplant-050718-100334","article-title":"MicroRNAs and their regulatory roles in plant\u2013environment interactions.","volume":"70","author":"Song","year":"2019","journal-title":"Annual Review of Plant Biology"},{"key":"2022031615000853400_CIT0116","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/jxb\/eraa441","article-title":"The many facets of protein ubiquitination and degradation in plant root iron-deficiency responses.","volume":"72","author":"Spielmann","year":"2021","journal-title":"Journal of Experimental Botany"},{"key":"2022031615000853400_CIT0117","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1105\/tpc.104.022830","article-title":"Novel and stress-regulated microRNAs and other small RNAs from Arabidopsis.","volume":"16","author":"Sunkar","year":"2004","journal-title":"The Plant Cell"},{"key":"2022031615000853400_CIT0118","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1186\/1471-2164-15-766","article-title":"Genome-wide identification of microRNA and siRNA responsive to endophytic beneficial diazotrophic bacteria in maize.","volume":"15","author":"Thiebaut","year":"2014","journal-title":"BMC Genomics"},{"key":"2022031615000853400_CIT0119","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.pbi.2013.01.003","article-title":"Iron transport in plants: better be safe than sorry.","volume":"16","author":"Thomine","year":"2013","journal-title":"Current Opinion in Plant Biology"},{"key":"2022031615000853400_CIT0120","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.1176333","article-title":"Control of iron homeostasis by an iron-regulated ubiquitin ligase.","volume":"326","author":"Vashisht","year":"2009","journal-title":"Science"},{"key":"2022031615000853400_CIT0121","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/pcp\/pcz091","article-title":"Essential and detrimental\u2014an update on intracellular iron trafficking and homeostasis.","volume":"60","author":"Vigani","year":"2019","journal-title":"Plant & Cell Physiology"},{"key":"2022031615000853400_CIT0122","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tplants.2013.01.006","article-title":"Signals from chloroplasts and mitochondria for iron homeostasis regulation.","volume":"18","author":"Vigani","year":"2013","journal-title":"Trends in Plant Science"},{"key":"2022031615000853400_CIT0123","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nature08300","article-title":"Metalloproteins and metal sensing.","volume":"460","author":"Waldron","year":"2009","journal-title":"Nature"},{"key":"2022031615000853400_CIT0124","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2164-9-44","article-title":"Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice.","volume":"9","author":"Wang","year":"2008","journal-title":"BMC Genomics"},{"key":"2022031615000853400_CIT0125","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.molcel.2020.02.011","article-title":"FBXL5 regulates IRP2 stability in iron homeostasis via an oxygen-responsive [2Fe2S] cluster.","volume":"78","author":"Wang","year":"2020","journal-title":"Molecular Cell"},{"key":"2022031615000853400_CIT0126","doi-asserted-by":"crossref","first-page":"e26611","DOI":"10.4161\/psb.26611","article-title":"Optimal copper supply is required for normal plant iron deficiency responses.","volume":"8","author":"Waters","year":"2013","journal-title":"Plant Signaling & Behavior"},{"key":"2022031615000853400_CIT0127","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.1093\/jxb\/ers239","article-title":"Rosette iron deficiency transcript and microRNA profiling reveals links between copper and iron homeostasis in Arabidopsis thaliana.","volume":"63","author":"Waters","year":"2012","journal-title":"Journal of Experimental Botany"},{"key":"2022031615000853400_CIT0128","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0065-3233(02)60051-8","article-title":"Copper metalloregulation of gene expression.","volume":"60","author":"Winge","year":"2002","journal-title":"Advances in Protein Chemistry"},{"key":"2022031615000853400_CIT0129","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1111\/nph.12598","article-title":"Mla- and Rom1-mediated control of microRNA398 and chloroplast copper\/zinc superoxide dismutase regulates cell death in response to the barley powdery mildew fungus.","volume":"201","author":"Xu","year":"2014","journal-title":"New Phytologist"},{"key":"2022031615000853400_CIT0130","doi-asserted-by":"crossref","first-page":"13197","DOI":"10.1074\/jbc.M117.784249","article-title":"Endoplasmic reticulum\u2013mitochondria junction is required for iron homeostasis.","volume":"292","author":"Xue","year":"2017","journal-title":"Journal of Biological Chemistry"},{"key":"2022031615000853400_CIT0131","doi-asserted-by":"crossref","first-page":"16369","DOI":"10.1074\/jbc.M700138200","article-title":"Regulation of copper homeostasis by micro-RNA in Arabidopsis.","volume":"282","author":"Yamasaki","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"2022031615000853400_CIT0132","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1105\/tpc.108.060137","article-title":"SQUAMOSA promoter binding protein-like7 is a central regulator for copper homeostasis in Arabidopsis.","volume":"21","author":"Yamasaki","year":"2009","journal-title":"The Plant Cell"},{"key":"2022031615000853400_CIT0133","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1073\/pnas.1131932100","article-title":"Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.","volume":"100","author":"Yao","year":"2003","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2022031615000853400_CIT0134","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1039\/c3mt00086a","article-title":"Transition metals in plant photosynthesis.","volume":"5","author":"Yruela","year":"2013","journal-title":"Metallomics"},{"key":"2022031615000853400_CIT0135","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/cr.2008.26","article-title":"FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis.","volume":"18","author":"Yuan","year":"2008","journal-title":"Cell Research"},{"key":"2022031615000853400_CIT0136","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1105\/tpc.114.127340","article-title":"MicroRNA408 is critical for the HY5\u2013SPL7 gene network that mediates the coordinated response to light and copper.","volume":"26","author":"Zhang","year":"2014","journal-title":"The Plant Cell"},{"key":"2022031615000853400_CIT0137","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tplants.2019.10.009","article-title":"Unraveling the linkage between retrograde signaling and RNA metabolism in plants.","volume":"25","author":"Zhao","year":"2020","journal-title":"Trends in Plant Science"},{"key":"2022031615000853400_CIT0138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-3054.2011.01477.x","article-title":"MiR398 and plant stress responses.","volume":"143","author":"Zhu","year":"2011","journal-title":"Physiologia Plantarum"}],"container-title":["Journal of Experimental Botany"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jxb\/advance-article-pdf\/doi\/10.1093\/jxb\/erab521\/42256551\/erab521.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jxb\/article-pdf\/73\/6\/1735\/42922612\/erab521.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jxb\/article-pdf\/73\/6\/1735\/42922612\/erab521.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:57:02Z","timestamp":1699847822000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jxb\/article\/73\/6\/1735\/6446296"}},"subtitle":[],"editor":[{"given":"Nathalie","family":"Verbruggen","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Libre de Bruxelles, Belgium"}],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,30]]},"references-count":138,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,11,30]]},"published-print":{"date-parts":[[2022,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/jxb\/erab521","relation":{},"ISSN":["0022-0957","1460-2431"],"issn-type":[{"value":"0022-0957","type":"print"},{"value":"1460-2431","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,15]]},"published":{"date-parts":[[2021,11,30]]}}}