{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:50:56Z","timestamp":1790704256427,"version":"4.1.0"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Hainan Province Science and Technology Special"},{"name":"Hainan Provincial Key Research and Development Project of China"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960527"],"award-info":[{"award-number":["31960527"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programme of Introducing Talents of Discipline to Universities","award":["D20024"],"award-info":[{"award-number":["D20024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Melatonin is an essential phytohormone in the regulation of many plant processes, including during plant development and in response to stress. Pathogen infections cause serious damage to plants and reduce agricultural production. Recent studies indicate that melatonin plays important roles in alleviating bacterial, fungal, and viral diseases in plants and post-harvest fruits. Herein, we summarize information related to the effects of melatonin on plant disease resistance. Melatonin, reactive oxygen species, and reactive nitrogen species form a complex loop in plant\u2013pathogen interaction to regulate plant disease resistance. Moreover, crosstalk of melatonin with other phytohormones including salicylic acid, jasmonic acid, auxin, and abscisic acid further activates plant defense genes. Melatonin plays an important role not only in plant immunity but also in alleviating pathogenicity. We also summarize the known processes by which melatonin mediates pathogenicity via negatively regulating the expression levels of genes related to cell viability as well as virulence-related genes. The multiple mechanisms underlying melatonin influences on both plant immunity and pathogenicity support the recognition of the essential nature of melatonin in plant\u2013pathogen interactions, highlighting phytomelatonin as a critical molecule in plant immune responses.<\/jats:p>","DOI":"10.1093\/jxb\/erac111","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T12:16:51Z","timestamp":1647001011000},"page":"5874-5885","source":"Crossref","is-referenced-by-count":69,"title":["Phytomelatonin as a central molecule in plant disease resistance"],"prefix":"10.1093","volume":"73","author":[{"given":"Hongqiu","family":"Zeng","sequence":"first","affiliation":[{"name":"Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University , Haikou, Hainan province, 570228 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Bai","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University , Haikou, Hainan province, 570228 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxie","family":"Wei","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University , Haikou, Hainan province, 570228 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel J","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology, UT Health San Antonio, Long School of Medicine , San Antonio, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-877X","authenticated-orcid":false,"given":"Haitao","family":"Shi","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University , Haikou, Hainan province, 570228 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"2022093010581402000_CIT0001","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.foodchem.2016.10.123","article-title":"Melatonin treatment attenuates postharvest decay and maintains nutritional quality of strawberry fruits (Fragaria\u00d7anannasa cv. Selva) by enhancing GABA shunt activity.","volume":"221","author":"Aghdam","year":"2017","journal-title":"Food Chemistry"},{"key":"2022093010581402000_CIT0002","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1094\/PHYTO-11-19-0435-R","article-title":"Role of melatonin in arbuscular mycorrhizal fungi-induced resistance to fusarium wilt in cucumber.","volume":"110","author":"Ahammed","year":"2020","journal-title":"Phytopathology"},{"key":"2022093010581402000_CIT0003","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/jpi.12253","article-title":"Functions of melatonin in plants: a review.","volume":"59","author":"Arnao","year":"2015","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0004","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tplants.2018.10.010","article-title":"Melatonin: a new plant hormone and\/or a plant master regulator?","volume":"24","author":"Arnao","year":"2019","journal-title":"Trends in Plant Science"},{"key":"2022093010581402000_CIT0005","doi-asserted-by":"crossref","first-page":"152","DOI":"10.32794\/11250036","article-title":"Melatonin and reactive oxygen and nitrogen species: a model for the plant redox network","volume":"2","author":"Arnao","year":"2019","journal-title":"Melatonin Research"},{"key":"2022093010581402000_CIT0006","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/plb.13202","article-title":"Melatonin as a regulatory hub of plant hormone levels and action in stress situations.","volume":"23","author":"Arnao","year":"2021","journal-title":"Plant Biology"},{"key":"2022093010581402000_CIT0007","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/jpi.12364","article-title":"Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts.","volume":"61","author":"Back","year":"2016","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0008","doi-asserted-by":"crossref","first-page":"501","DOI":"10.32794\/mr112500108","article-title":"Strategies to generate melatonin-enriched transgenic rice to respond to the adverse effects on rice production potentially caused by global warming","volume":"4","author":"Back","year":"2021","journal-title":"Melatonin Research"},{"key":"2022093010581402000_CIT0009","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.plaphy.2019.10.033","article-title":"Melatonin application reduces fluoride uptake and toxicity in rice seedlings by altering abscisic acid, gibberellin, auxin and antioxidant homeostasis.","volume":"145","author":"Banerjee","year":"2019","journal-title":"Plant Physiology and Biochemistry"},{"key":"2022093010581402000_CIT0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/pcp\/pcx181","article-title":"Salicylic acid and jasmonic acid pathways are activated in spatially different domains around the infection site during effector-triggered immunity in Arabidopsis thaliana.","volume":"59","author":"Betsuyaku","year":"2018","journal-title":"Plant & Cell Physiology"},{"key":"2022093010581402000_CIT0011","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/ppa.13018","article-title":"Exogenous application of melatonin improves eradication of Apple stem grooving virus from the infected in vitro shoots by shoot tip culture","volume":"68","author":"Chen","year":"2019","journal-title":"Plant Pathology"},{"key":"2022093010581402000_CIT0012","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jplph.2008.06.002","article-title":"Exogenously applied melatonin stimulates root growth and raises endogenous indoleacetic acid in roots of etiolated seedlings of Brassica juncea.","volume":"166","author":"Chen","year":"2009","journal-title":"Journal of Plant Physiology"},{"key":"2022093010581402000_CIT0013","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1094\/PDIS-11-19-2361-RE","article-title":"Exogenous melatonin enhances rice plant resistance against Xanthomonas oryzae pv. oryzae.","volume":"104","author":"Chen","year":"2020","journal-title":"Plant Disease"},{"key":"2022093010581402000_CIT0014","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jxb\/erh033","article-title":"ABA, hydrogen peroxide and nitric oxide signalling in stomatal guard cells.","volume":"55","author":"Desikan","year":"2004","journal-title":"Journal of Experimental Botany"},{"key":"2022093010581402000_CIT0015","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.tplants.2020.01.004","article-title":"Stories of salicylic acid: a plant defense hormone.","volume":"25","author":"Ding","year":"2020","journal-title":"Trends in Plant Science"},{"key":"2022093010581402000_CIT0016","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-079X.1995.tb00136.x","article-title":"Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography\u2013mass spectrometry.","volume":"18","author":"Dubbels","year":"1995","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0017","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature10947","article-title":"Emerging fungal threats to animal, plant and ecosystem health.","volume":"484","author":"Fisher","year":"2012","journal-title":"Nature"},{"key":"2022093010581402000_CIT0018","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1089\/ars.2013.5278","article-title":"Redox signaling in plants.","volume":"18","author":"Foyer","year":"2013","journal-title":"Antioxidants & Redox Signaling"},{"key":"2022093010581402000_CIT0019","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0960-9822(00)00560-1","article-title":"The hypersensitive response facilitates plant infection by the necrotrophic pathogen Botrytis cinerea.","volume":"10","author":"Govrin","year":"2000","journal-title":"Current Biology"},{"key":"2022093010581402000_CIT0020","doi-asserted-by":"crossref","first-page":"7482","DOI":"10.3390\/ijms21207482","article-title":"Jasmonic acid at the crossroads of plant immunity and Pseudomonas syringae virulence","volume":"21","author":"Gupta","year":"2020","journal-title":"International Journal of Molecular Science"},{"key":"2022093010581402000_CIT0021","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/ppl.13143","article-title":"Crosstalk between melatonin and nitric oxide in plant development and stress responses.","volume":"170","author":"He","year":"2020","journal-title":"Physiologia Plantarum"},{"key":"2022093010581402000_CIT0022","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-phyto-072910-095355","article-title":"Reactive oxygen species in phytopathogenic fungi: signaling, development, and disease.","volume":"49","author":"Heller","year":"2011","journal-title":"Annual Review of Phytopathology"},{"key":"2022093010581402000_CIT0023","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/s12870-019-1992-7","article-title":"Melatonin alleviates heat-induced damage of tomato seedlings by balancing redox homeostasis and modulating polyamine and nitric oxide biosynthesis.","volume":"19","author":"Jahan","year":"2019","journal-title":"BMC Plant Biology"},{"key":"2022093010581402000_CIT0024","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.phyto.43.011205.141140","article-title":"Genetics of plant virus resistance.","volume":"43","author":"Kang","year":"2005","journal-title":"Annual Review of Phytopathology"},{"key":"2022093010581402000_CIT0025","doi-asserted-by":"crossref","first-page":"691835","DOI":"10.3389\/fpls.2021.691835","article-title":"Melatonin and its homologs induce immune responses via receptors trP47363-trP13076 in Nicotiana benthamiana.","volume":"12","author":"Kong","year":"2021","journal-title":"Frontiers in Plant Science"},{"key":"2022093010581402000_CIT0026","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/jxb\/eri086","article-title":"Compartment-specific role of the ascorbate-glutathione cycle in the response of tomato leaf cells to Botrytis cinerea infection","volume":"56","author":"Ku\u017aniak","year":"2005","journal-title":"Journal of Experimental Botany"},{"key":"2022093010581402000_CIT0027","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/jpi.12314","article-title":"Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants.","volume":"60","author":"Lee","year":"2016","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0028","doi-asserted-by":"crossref","first-page":"e12379","DOI":"10.1111\/jpi.12379","article-title":"Melatonin is required for H2O2- and NO-mediated defense signaling through MAPKKK3 and OXI1 in Arabidopsis thaliana","volume":"62","author":"Lee","year":"2017","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0029","doi-asserted-by":"crossref","first-page":"e12504","DOI":"10.1111\/jpi.12504","article-title":"Melatonin induction and its role in high light stress tolerance in Arabidopsis thaliana.","volume":"65","author":"Lee","year":"2018","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0030","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/jpi.12165","article-title":"Melatonin as a signal molecule triggering defense responses against pathogen attack in Arabidopsis and tobacco.","volume":"57","author":"Lee","year":"2014","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0031","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/jpi.12214","article-title":"Arabidopsis serotonin N-acetyltransferase knockout mutant plants exhibit decreased melatonin and salicylic acid levels resulting in susceptibility to an avirulent pathogen.","volume":"58","author":"Lee","year":"2015","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0032","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1021\/ja01543a060","article-title":"Isolation of melatonin, the pineal gland factor that lightens melanocytes","volume":"80","author":"Lerner","year":"1958","journal-title":"Journal of the American Chemical Society"},{"key":"2022093010581402000_CIT0033","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/tpj.14477","article-title":"Melatonin enhances cotton immunity to Verticillium wilt via manipulating lignin and gossypol biosynthesis.","volume":"100","author":"Li","year":"2019","journal-title":"The Plant Journal"},{"key":"2022093010581402000_CIT0034","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1600-079X.2012.00999.x","article-title":"The mitigation effects of exogenous melatonin on salinity-induced stress in Malus hupehensis.","volume":"53","author":"Li","year":"2012","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0035","doi-asserted-by":"crossref","first-page":"e12523","DOI":"10.1111\/jpi.12523","article-title":"The mitigation effects of exogenous melatonin on replant disease in apple.","volume":"65","author":"Li","year":"2018","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0036","doi-asserted-by":"crossref","first-page":"e12640","DOI":"10.1111\/jpi.12640","article-title":"Daily rhythms of phytomelatonin signaling modulate diurnal stomatal closure via regulating reactive oxygen species dynamics in Arabidopsis.","volume":"68","author":"Li","year":"2020","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0037","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3390\/molecules24091826","article-title":"Exogenous melatonin enhances cold, salt and drought stress tolerance by improving antioxidant defense in tea plant (Camellia sinensis (L.) O. Kuntze)","volume":"24","author":"Li","year":"2019","journal-title":"Molecules"},{"key":"2022093010581402000_CIT0038","doi-asserted-by":"crossref","first-page":"1659705","DOI":"10.1080\/15592324.2019.1659705","article-title":"Exogenous melatonin improves seed germination in Limonium bicolor under salt stress.","volume":"14","author":"Li","year":"2019","journal-title":"Plant Signaling & Behavior"},{"key":"2022093010581402000_CIT0039","doi-asserted-by":"crossref","first-page":"110962","DOI":"10.1016\/j.postharvbio.2019.110962","article-title":"Melatonin treatment inhibits gray mold and induces disease resistance in cherry tomato fruit during postharvest","volume":"157","author":"Li","year":"2019","journal-title":"Postharvest Biology and Technology"},{"key":"2022093010581402000_CIT0040","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12870-019-1855-2","article-title":"Comparative transcriptomic and metabolic analysis reveals the effect of melatonin on delaying anthracnose incidence upon postharvest banana fruit peel","volume":"19","author":"Li","year":"2019","journal-title":"BMC Plant Biology"},{"key":"2022093010581402000_CIT0041","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tplants.2021.12.008","article-title":"Phytomelatonin prevents bacterial invasion during nighttime","volume":"27","author":"Li","year":"2022","journal-title":"Trends in Plant Science"},{"key":"2022093010581402000_CIT0042","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/aps.2011.101","article-title":"Effects of Rhein lysinate on H2O2-induced cellular senescence of human umbilical vascular endothelial cells.","volume":"32","author":"Lin","year":"2011","journal-title":"Acta Pharmacologica Sinica"},{"key":"2022093010581402000_CIT0043","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.postharvbio.2019.03.016","article-title":"Melatonin decreases resistance to postharvest green mold on citrus fruit by scavenging defense-related reactive oxygen species","volume":"153","author":"Lin","year":"2019","journal-title":"Postharvest Biology and Technology"},{"key":"2022093010581402000_CIT0044","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1105\/tpc.109.066464","article-title":"Redox regulation of the NPR1\u2013TGA1 system of Arabidopsis thaliana by nitric oxide.","volume":"22","author":"Lindermayr","year":"2010","journal-title":"The Plant Cell"},{"key":"2022093010581402000_CIT0045","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1021\/acs.jafc.9b00058","article-title":"Melatonin induces disease resistance to Botrytis cinerea in tomato fruit by activating jasmonic acid signaling pathway.","volume":"67","author":"Liu","year":"2019","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"2022093010581402000_CIT0046","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10658-021-02279-8","article-title":"Defense-related hormone signaling coordinately controls the role of melatonin during Arabidopsis thaliana\u2013Pseudomonas syringae interaction","volume":"160","author":"Liu","year":"2021","journal-title":"European Journal of Plant Pathology"},{"key":"2022093010581402000_CIT0047","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12985-019-1228-3","article-title":"Melatonin is responsible for rice resistance to Rice stripe virus infection through a nitric oxide-dependent pathway.","volume":"16","author":"Lu","year":"2019","journal-title":"Virology Journal"},{"key":"2022093010581402000_CIT0048","doi-asserted-by":"crossref","first-page":"e12505","DOI":"10.1111\/jpi.12505","article-title":"Differential roles of melatonin in plant-host resistance and pathogen suppression in cucurbits.","volume":"65","author":"Mandal","year":"2018","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0049","doi-asserted-by":"crossref","first-page":"e12598","DOI":"10.1111\/jpi.12598","article-title":"Melatonin reduces inflammatory response in human intestinal epithelial cells stimulated by interleukin-1\u03b2.","volume":"67","author":"Mannino","year":"2019","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0050","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1186\/s12870-020-02747-z","article-title":"Melatonin promotes adventitious root formation in apple by promoting the function of MdWOX11.","volume":"20","author":"Mao","year":"2020","journal-title":"BMC Plant Biology"},{"key":"2022093010581402000_CIT0051","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1104\/pp.16.01734","article-title":"Nitric oxide modulates histone acetylation at stress genes by inhibition of histone deacetylases.","volume":"173","author":"Mengel","year":"2017","journal-title":"Plant Physiology"},{"key":"2022093010581402000_CIT0052","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tplants.2016.08.002","article-title":"ROS are good.","volume":"22","author":"Mittler","year":"2017","journal-title":"Trends in Plant Science"},{"key":"2022093010581402000_CIT0053","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1093\/jxb\/erv297","article-title":"The nexus between growth and defence signalling: auxin and cytokinin modulate plant immune response pathways.","volume":"66","author":"Naseem","year":"2015","journal-title":"Journal of Experimental Botany"},{"key":"2022093010581402000_CIT0054","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2174\/1389203716666150330124911","article-title":"Auxin crosstalk to plant immune networks: a plant\u2013pathogen interaction perspective.","volume":"16","author":"Naseem","year":"2015","journal-title":"Current Protein & Peptide Science"},{"key":"2022093010581402000_CIT0055","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1104\/pp.20.00393","article-title":"Melatonin is involved in Citrus response to the pathogen Huanglongbing via modulation of phytohormonal biosynthesis.","volume":"184","author":"Nehela","year":"2020","journal-title":"Plant Physiology"},{"key":"2022093010581402000_CIT0056","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.freeradbiomed.2015.01.028","article-title":"Oxidative stress alters global histone modification and DNA methylation.","volume":"82","author":"Niu","year":"2015","journal-title":"Free Radical Biology & Medicine"},{"key":"2022093010581402000_CIT0057","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3390\/molecules23030675","article-title":"Melatonin balance the autophagy and apoptosis by regulating UCP2 in the LPS-induced cardiomyopathy","volume":"23","author":"Pan","year":"2018","journal-title":"Molecules"},{"key":"2022093010581402000_CIT0058","doi-asserted-by":"crossref","first-page":"15815","DOI":"10.1038\/srep15815","article-title":"Comparative metabolomic analysis highlights the involvement of sugars and glycerol in melatonin-mediated innate immunity against bacterial pathogen in Arabidopsis.","volume":"5","author":"Qian","year":"2015","journal-title":"Scientific Reports"},{"key":"2022093010581402000_CIT0059","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: under promises but over delivers.","volume":"61","author":"Reiter","year":"2016","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0060","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.molp.2019.05.006","article-title":"Systems biology of plant\u2013microbiome interactions.","volume":"12","author":"Rodriguez","year":"2019","journal-title":"Molecular Plant"},{"key":"2022093010581402000_CIT0061","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/antiox10071128","article-title":"GSNOR contributes to demethylation and expression of transposable elements and stress-responsive genes","volume":"10","author":"Rudolf","year":"2021","journal-title":"Antioxidants"},{"key":"2022093010581402000_CIT0062","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3390\/plants10030459","article-title":"Molecular characterization of the Alfalfa mosaic virus infecting Solanum melongena in Egypt and the control of its deleterious effects with melatonin and salicylic acid","volume":"10","author":"Sofy","year":"2021","journal-title":"Plants"},{"key":"2022093010581402000_CIT0063","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.redox.2018.07.004","article-title":"Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: implication of an antioxidation-independent mechanism.","volume":"18","author":"Shen","year":"2018","journal-title":"Redox Biology"},{"key":"2022093010581402000_CIT0064","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/jpi.12244","article-title":"Melatonin induces nitric oxide and the potential mechanisms relate to innate immunity against bacterial pathogen infection in Arabidopsis.","volume":"59","author":"Shi","year":"2015","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0065","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/jpi.12262","article-title":"Melatonin induces the transcripts of CBF\/DREB1s and their involvement in both abiotic and biotic stresses in Arabidopsis.","volume":"59","author":"Shi","year":"2015","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0066","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41586-020-2027-0","article-title":"Virtual discovery of melatonin receptor ligands to modulate circadian rhythms.","volume":"579","author":"Stein","year":"2020","journal-title":"Nature"},{"key":"2022093010581402000_CIT0067","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.scienta.2019.04.057","article-title":"Effect of exogenous melatonin on resistance of cucumber to downy mildew","volume":"255","author":"Sun","year":"2019","journal-title":"Scientia Horticulturae"},{"key":"2022093010581402000_CIT0068","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jipb.12993","article-title":"Melatonin: a master regulator of plant development and stress responses.","volume":"63","author":"Sun","year":"2021","journal-title":"Journal of Integrative Plant Biology"},{"key":"2022093010581402000_CIT0069","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1126\/science.1156970","article-title":"Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins.","volume":"321","author":"Tada","year":"2008","journal-title":"Science"},{"key":"2022093010581402000_CIT0070","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1093\/jxb\/eraa235","article-title":"An evolutionary view of melatonin synthesis and metabolism related to its biological functions in plants.","volume":"71","author":"Tan","year":"2020","journal-title":"Journal of Experimental Botany"},{"key":"2022093010581402000_CIT0071","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.3390\/ijms20215355","article-title":"Melatonin-induced transcriptome variation of rapeseed seedlings under salt stress","volume":"20","author":"Tan","year":"2019","journal-title":"International Journal of Molecular Science"},{"key":"2022093010581402000_CIT0072","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1600-079X.2007.00516.x","article-title":"Melatonin as an antibiotic: new insights into the actions of this ubiquitous molecule.","volume":"44","author":"Tekbas","year":"2008","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0073","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1094\/MPMI-09-14-0259-R","article-title":"Salicylic acid inhibits the replication of tomato bushy stunt virus by directly targeting a host component in the replication complex.","volume":"28","author":"Tian","year":"2015","journal-title":"Molecular Plant-Microbe Interactions"},{"key":"2022093010581402000_CIT0074","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1104\/pp.105.069625","article-title":"Heterotrimeric G proteins facilitate Arabidopsis resistance to necrotrophic pathogens and are involved in jasmonate signaling.","volume":"140","author":"Trusov","year":"2006","journal-title":"Plant Physiology"},{"key":"2022093010581402000_CIT0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-079X.2011.00966.x","article-title":"Delayed senescence of apple leaves by exogenous melatonin treatment: toward regulating the ascorbate\u2013glutathione cycle.","volume":"53","author":"Wang","year":"2012","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0076","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3389\/fpls.2016.01882","article-title":"Melatonin regulates root meristem by repressing auxin synthesis and polar auxin transport in arabidopsis.","volume":"7","author":"Wang","year":"2016","journal-title":"Frontiers in Plant Science"},{"key":"2022093010581402000_CIT0077","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.molp.2020.05.013","article-title":"S-Nitrosylation control of ROS and RNS homeostasis in plants: the switching function of catalase.","volume":"13","author":"Wang","year":"2020","journal-title":"Molecular Plant"},{"key":"2022093010581402000_CIT0078","doi-asserted-by":"crossref","first-page":"e93462","DOI":"10.1371\/journal.pone.0093462","article-title":"Arabidopsis transcriptome analysis reveals key roles of melatonin in plant defense systems.","volume":"9","author":"Weeda","year":"2014","journal-title":"PLoS One"},{"key":"2022093010581402000_CIT0079","doi-asserted-by":"crossref","first-page":"e12500","DOI":"10.1111\/jpi.12500","article-title":"Phytomelatonin receptor PMTR1-mediated signaling regulates stomatal closure in Arabidopsis thaliana.","volume":"65","author":"Wei","year":"2018","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0080","doi-asserted-by":"crossref","first-page":"e12454","DOI":"10.1111\/jpi.12454","article-title":"RAV transcription factors are essential for disease resistance against cassava bacterial blight via activation of melatonin biosynthesis genes","volume":"64","author":"Wei","year":"2017","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0081","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3389\/fpls.2016.00676","article-title":"Comparative transcriptional profiling of melatonin synthesis and catabolic genes indicates the possible role of melatonin in developmental and stress responses in rice.","volume":"7","author":"Wei","year":"2016","journal-title":"Frontiers in Plant Science"},{"key":"2022093010581402000_CIT0082","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3389\/fpls.2016.00718","article-title":"Promoting roles of melatonin in adventitious root development of Solanum lycopersicum L. by regulating auxin and nitric oxide signaling.","volume":"7","author":"Wen","year":"2016","journal-title":"Frontiers in Plant Science"},{"key":"2022093010581402000_CIT0083","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/ppa.12954","article-title":"Melatonin treatments reduce the pathogenicity and inhibit the growth of Xanthomonas oryzae pv. oryzicola","volume":"68","author":"Xian","year":"2019","journal-title":"Plant Pathology"},{"key":"2022093010581402000_CIT0084","doi-asserted-by":"crossref","first-page":"e12607","DOI":"10.1111\/jpi.12607","article-title":"Melatonin\/PGC1A\/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning.","volume":"67","author":"Xiao","year":"2019","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41438-018-0045-y","article-title":"Melatonin promotes ripening of grape berry via increasing the levels of ABA, H2O2, and particularly ethylene.","volume":"5","author":"Xu","year":"2018","journal-title":"Horticulture Research"},{"key":"2022093010581402000_CIT0086","doi-asserted-by":"crossref","first-page":"e12659","DOI":"10.1111\/jpi.12659","article-title":"Melatonin confers cadmium tolerance by modulating critical heavy metal chelators and transporters in radish plants.","volume":"69","author":"Xu","year":"2020","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0087","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1093\/plphys\/kiab419","article-title":"Melatonin functions in priming of stomatal immunity in Panax notoginseng and Arabidopsis thaliana.","volume":"187","author":"Yang","year":"2021","journal-title":"Plant Physiology"},{"key":"2022093010581402000_CIT0088","doi-asserted-by":"crossref","first-page":"20932","DOI":"10.1073\/pnas.1922319117","article-title":"Stomatal immunity against fungal invasion comprises not only chitin-induced stomatal closure but also chitosan-induced guard cell death.","volume":"117","author":"Ye","year":"2020","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"2022093010581402000_CIT0089","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/jpi.12038","article-title":"Exogenous melatonin improves Malus resistance to Marssonina apple blotch.","volume":"54","author":"Yin","year":"2013","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0090","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.3390\/molecules23081887","article-title":"The role of phyto-melatonin and related metabolites in response to stress","volume":"23","author":"Yu","year":"2018","journal-title":"Molecules"},{"key":"2022093010581402000_CIT0091","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/nph.13903","article-title":"Nitric oxide and S-nitrosoglutathione function additively during plant immunity.","volume":"211","author":"Yun","year":"2016","journal-title":"New Phytologist"},{"key":"2022093010581402000_CIT0092","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3390\/ijms20030709","article-title":"Melatonin: a small molecule but important for salt stress tolerance in plants","volume":"20","author":"Zhan","year":"2019","journal-title":"International Journal of Molecular Science"},{"key":"2022093010581402000_CIT0093","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/jxb\/eru336","article-title":"Roles of melatonin in abiotic stress resistance in plants.","volume":"66","author":"Zhang","year":"2015","journal-title":"Journal of Experimental Botany"},{"key":"2022093010581402000_CIT0094","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-079X.2012.01015.x","article-title":"Melatonin promotes water-stress tolerance, lateral root formation, and seed germination in cucumber (Cucumis sativus L.).","volume":"54","author":"Zhang","year":"2013","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0095","doi-asserted-by":"crossref","first-page":"e12492","DOI":"10.1111\/jpi.12492","article-title":"Synergistic anti-oomycete effect of melatonin with a biofungicide against oomycetic black shank disease.","volume":"65","author":"Zhang","year":"2018","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0096","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3389\/fpls.2017.01993","article-title":"Melatonin attenuates potato late blight by disrupting cell growth, stress tolerance, fungicide susceptibility and homeostasis of gene expression in Phytophthora infestans.","volume":"8","author":"Zhang","year":"2017","journal-title":"Frontiers in Plant Science"},{"key":"2022093010581402000_CIT0097","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00344-021-10317-2","article-title":"Versatile roles of melatonin in growth and stress tolerance in plants","volume":"41","author":"Zhang","year":"2022","journal-title":"Journal of Plant Growth Regulation"},{"key":"2022093010581402000_CIT0098","doi-asserted-by":"crossref","first-page":"129009","DOI":"10.1016\/j.foodchem.2021.129009","article-title":"Inhibition of downy blight and enhancement of resistance in litchi fruit by postharvest application of melatonin.","volume":"347","author":"Zhang","year":"2021","journal-title":"Food Chemistry"},{"key":"2022093010581402000_CIT0099","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tplants.2020.08.009","article-title":"Phytomelatonin: an emerging regulator of plant biotic stress resistance.","volume":"26","author":"Zhao","year":"2021","journal-title":"Trends in Plant Science"},{"key":"2022093010581402000_CIT0100","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jpi.12245","article-title":"Melatonin regulates carbohydrate metabolism and defenses against Pseudomonas syringae pv. tomato DC3000 infection in Arabidopsis thaliana.","volume":"59","author":"Zhao","year":"2015","journal-title":"Journal of Pineal Research"},{"key":"2022093010581402000_CIT0101","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1104\/pp.19.00913","article-title":"H2Bub1 regulates RbohD-dependent hydrogen peroxide signal pathway in the defense responses to Verticillium dahliae toxins.","volume":"182","author":"Zhao","year":"2020","journal-title":"Plant Physiology"},{"key":"2022093010581402000_CIT0102","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/ppa.13057","article-title":"Exogenous application of melatonin improves plant resistance to virus infection","volume":"68","author":"Zhao","year":"2019","journal-title":"Plant Pathology"},{"key":"2022093010581402000_CIT0103","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1093\/jxb\/eru217","article-title":"H2O2 mediates the crosstalk of brassinosteroid and abscisic acid in tomato responses to heat and oxidative stresses.","volume":"65","author":"Zhou","year":"2014","journal-title":"Journal of Experimental Botany"},{"key":"2022093010581402000_CIT0104","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.3390\/ijms20246200","article-title":"Melatonin-\u2013nitric oxide crosstalk and their roles in the redox network in plants","volume":"20","author":"Zhu","year":"2019","journal-title":"International Journal of Molecular Science"},{"key":"2022093010581402000_CIT0105","doi-asserted-by":"crossref","first-page":"683228","DOI":"10.3389\/fpls.2021.683228","article-title":"Roles of endogenous melatonin in resistance to Botrytis cinerea infection in an arabidopsis model.","volume":"12","author":"Zhu","year":"2021","journal-title":"Frontiers in Plant Science"},{"key":"2022093010581402000_CIT0106","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1111\/bph.14116","article-title":"New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.","volume":"175","author":"Zisapel","year":"2018","journal-title":"British Journal of Pharmacology"}],"container-title":["Journal of Experimental Botany"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jxb\/advance-article-pdf\/doi\/10.1093\/jxb\/erac111\/43556297\/erac111.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jxb\/article-pdf\/73\/17\/5874\/46212561\/erac111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jxb\/article-pdf\/73\/17\/5874\/46212561\/erac111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T11:18:57Z","timestamp":1664536737000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jxb\/article\/73\/17\/5874\/6550107"}},"subtitle":[],"editor":[{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Kunming University of Science and Technology , China"}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,17]]},"references-count":106,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,3,17]]},"published-print":{"date-parts":[[2022,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jxb\/erac111","relation":{},"ISSN":["0022-0957","1460-2431"],"issn-type":[{"value":"0022-0957","type":"print"},{"value":"1460-2431","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,30]]},"published":{"date-parts":[[2022,3,17]]}}}