{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:05:06Z","timestamp":1790802306008,"version":"4.1.0"},"reference-count":151,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41930758"],"award-info":[{"award-number":["41930758"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["SBK2021043592"],"award-info":[{"award-number":["SBK2021043592"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Soil contamination with trace metals and metalloids can cause toxicity to plants and threaten food safety and human health. Plants have evolved sophisticated mechanisms to cope with excess trace metals and metalloids in soils, including chelation and vacuolar sequestration. Sulfur-containing compounds, such as glutathione and phytochelatins, play a crucial role in their detoxification, and sulfur uptake and assimilation are regulated in response to the stress of toxic trace metals and metalloids. This review focuses on the multi-level connections between sulfur homeostasis in plants and responses to such stresses, especially those imposed by arsenic and cadmium. We consider recent progress in understanding the regulation of biosynthesis of glutathione and phytochelatins and of the sensing mechanism of sulfur homeostasis for tolerance of trace metals and metalloids in plants. We also discuss the roles of glutathione and phytochelatins in controlling the accumulation and distribution of arsenic and cadmium in plants, and possible strategies for manipulating sulfur metabolism to limit their accumulation in food crops.<\/jats:p>","DOI":"10.1093\/jxb\/erad074","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T06:53:38Z","timestamp":1677221618000},"page":"3286-3299","source":"Crossref","is-referenced-by-count":50,"title":["Regulatory mechanisms of sulfur metabolism affecting tolerance and accumulation of toxic trace metals and metalloids in plants"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-3928","authenticated-orcid":false,"given":"Sheng-Kai","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Resources and Environmental Sciences, Nanjing Agricultural University , Nanjing 210095 , China"},{"name":"Centre for Organismal Studies (COS), Heidelberg University , 69120 Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-7314","authenticated-orcid":false,"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Resources and Environmental Sciences, Nanjing Agricultural University , Nanjing 210095 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-169X","authenticated-orcid":false,"given":"Fang-Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Resources and Environmental Sciences, Nanjing Agricultural University , Nanjing 210095 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"2023060913434383700_CIT0001","doi-asserted-by":"crossref","first-page":"e1601087","DOI":"10.1126\/sciadv.1601087","article-title":"Sulfur deficiency-induced repressor proteins optimize glucosinolate biosynthesis in plants","volume":"2","author":"Aarabi","year":"2016","journal-title":"Science Advances"},{"key":"2023060913434383700_CIT0002","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1093\/plphys\/kiab386","article-title":"Sulfur deficiency-induced genes affect seed protein accumulation and composition under sulfate deprivation","volume":"187","author":"Aarabi","year":"2021","journal-title":"Plant Physiology"},{"key":"2023060913434383700_CIT0003","doi-asserted-by":"crossref","first-page":"E450","DOI":"10.1073\/pnas.1100659108","article-title":"Monoubiquitin-dependent endocytosis of the IRON-REGULATED TRANSPORTER 1 (IRT1) 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