{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:40:53Z","timestamp":1792086053068,"version":"4.4.0"},"reference-count":100,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"ERDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"AEI","doi-asserted-by":"publisher","award":["BIO2016-76633-P"],"award-info":[{"award-number":["BIO2016-76633-P"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"AEI","doi-asserted-by":"publisher","award":["PID2021-127450NB-I00"],"award-info":[{"award-number":["PID2021-127450NB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P20_00030"],"award-info":[{"award-number":["P20_00030"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The high phenotypic plasticity developed by plants includes rapid responses and adaptations to aggressive or changing environments. To achieve this, they evolved extremely efficient mechanisms of signaling mediated by a wide range of molecules, including small signal molecules. Among them, hydrogen cyanide (HCN) has been largely ignored due to its toxic characteristics. However, not only is it present in living organisms, but it has been shown that it serves several functions in all kingdoms of life. Research using model plants has changed the traditional point of view, and it has been demonstrated that HCN plays a positive role in the plant response to pathogens independently of its toxicity. Indeed, HCN induces a response aimed at protecting the plant from pathogen attack, and the HCN is provided either exogenously (in vitro or by some cyanogenic bacteria species present in the rhizosphere) or endogenously (in reactions involving ethylene, camalexin, or other cyanide-containing compounds). The contribution of different mechanisms to HCN function, including a new post-translational modification of cysteines in proteins, namely S-cyanylation, is discussed here. This work opens up an expanding \u2018HCN field\u2019 of research related to plants and other organisms.<\/jats:p>","DOI":"10.1093\/jxb\/erad317","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T21:34:00Z","timestamp":1692221640000},"page":"6040-6051","source":"Crossref","is-referenced-by-count":45,"title":["Old poisons, new signaling molecules: the case of hydrogen cyanide"],"prefix":"10.1093","volume":"74","author":[{"given":"Pablo","family":"Di\u0301az-Rueda","sequence":"first","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis (IBVF), CSIC-Universidad de Sevilla , 41092-Sevilla , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Morales de los Ri\u0301os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2414-4813","authenticated-orcid":false,"given":"Luis C","family":"Romero","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis (IBVF), CSIC-Universidad de Sevilla , 41092-Sevilla , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Garci\u0301a","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica Vegetal y Fotos\u00edntesis (IBVF), CSIC-Universidad de Sevilla , 41092-Sevilla , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"2023101321595932300_CIT0001","doi-asserted-by":"crossref","first-page":"e1537699","DOI":"10.1080\/15592324.2018.1537699","article-title":"Role of mitochondrial cyanide detoxification in Arabidopsis root hair development","volume":"13","author":"Arenas-Alfonseca","year":"2018","journal-title":"Plant Signaling & Behavior"},{"key":"2023101321595932300_CIT0002","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/pcp\/pcy047","article-title":"\u03b2-Cyanoalanine synthase action in root hair elongation is exerted at early steps of the root hair elongation pathway and is independent of direct cyanide inactivation of NADPH oxidase","volume":"59","author":"Arenas-Alfonseca","year":"2018","journal-title":"Plant and Cell Physiology"},{"key":"2023101321595932300_CIT0003","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1093\/jxb\/erab137","article-title":"Mutation in Arabidopsis \u03b2-cyanoalanine synthase overcomes NADPH oxidase action in response to pathogens","volume":"72","author":"Arenas-Alfonseca","year":"2021","journal-title":"Journal Experimental Botany"},{"key":"2023101321595932300_CIT0004","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1093\/plphys\/kiac170","article-title":"Hydroxynitrile lyase defends Arabidopsis against Tetranychus urticae","volume":"189","author":"Arnaiz","year":"2022","journal-title":"Plant Physiology"},{"key":"2023101321595932300_CIT0005","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3389\/fpls.2018.01369","article-title":"Hydrogen sulfide signaling in plants: emerging roles of protein persulfidation","volume":"9","author":"Aroca","year":"2018","journal-title":"Frontiers in Plant Science"},{"key":"2023101321595932300_CIT0006","doi-asserted-by":"crossref","first-page":"15193","DOI":"10.3390\/ijms131115193","article-title":"Nitric oxide-dependent posttranslational modification in plants: an update","volume":"13","author":"Astier","year":"2012","journal-title":"International Journal of Molecular Science"},{"key":"2023101321595932300_CIT0007","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s10886-006-9114-z","article-title":"Oviposition choice of Mexican bean beetle (Epilachna varivestis) depends on host plants cyanogenic capacity","volume":"32","author":"Ballhorn","year":"2006","journal-title":"Journal of Chemical Ecology"},{"key":"2023101321595932300_CIT0008","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1021\/ja01543a037","article-title":"Reactions of elemental sulfur. 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