{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:42:17Z","timestamp":1792456937903,"version":"4.5.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministry of Science and Technology of China","award":["2021YFF1000402"],"award-info":[{"award-number":["2021YFF1000402"]}]},{"name":"Key Research Project of the Zhejiang Lab","award":["2021PE0AC04"],"award-info":[{"award-number":["2021PE0AC04"]}]},{"name":"Northeast Institute of Geography and Agroecology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Iron (Fe), manganese (Mn), copper (Cu), and zinc (Zn) are essential micronutrients that are necessary for plant growth and development, but can be toxic at supra-optimal levels. Plants have evolved a complex homeostasis network that includes uptake, transport, and storage of these metals. It was shown that the transcription factor (TF) complex OsbHLH156\u2013OsIRO2 is activated under Fe deficient conditions and acts as a central regulator on Strategy II Fe acquisition. In this study, the role of the TF complex on Mn, Cu, and Zn uptake was evaluated. While Fe deficiency led to significant increases in shoot Mn, Cu, and Zn concentrations, the increases of these divalent metal concentrations were significantly suppressed in osbhlh156 and osiro2 mutants, suggesting that the TF complex plays roles on Mn, Cu, and Zn uptake and transport. An RNA-sequencing assay showed that the genes associated with Mn, Cu, and Zn uptake and transport were significantly suppressed in the osbhlh156 and osiro2 mutants. Transcriptional activation assays demonstrated that the TF complex could directly bind to the promoters of OsIRT1, OsYSL15, OsNRAMP6, OsHMA2, OsCOPT1\/7, and OsZIP5\/9\/10, and activate their expression. In addition, the TF complex is required to activate the expression of nicotianamine (NA) and 2'-deoxymugineic acid (DMA) synthesis genes, which in turn facilitate the uptake and transport of Mn, Cu, and Zn. Furthermore, OsbHLH156 and OsIRO2 promote Cu accumulation to partially restore the Fe-deficiency symptoms. Taken together, OsbHLH156 and OsIRO2 TF function as core regulators not only in Fe homeostasis, but also in Mn, Cu, and Zn accumulation.<\/jats:p>","DOI":"10.1093\/jxb\/erad439","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T01:08:12Z","timestamp":1699405692000},"page":"1112-1127","source":"Crossref","is-referenced-by-count":13,"title":["Role of transcription factor complex OsbHLH156\u2013OsIRO2 in regulating manganese, copper, and zinc transporters in rice"],"prefix":"10.1093","volume":"75","author":[{"given":"Jiamei","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou, Zhejiang 310058 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou, Zhejiang 310058 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou, Zhejiang 310058 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou, Zhejiang 310058 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou, Zhejiang 310058 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-0267","authenticated-orcid":false,"given":"Shoudong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China"},{"name":"Zhejiang Lab , Hangzhou 310012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6890-5672","authenticated-orcid":false,"given":"Huixia","family":"Shou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University , Hangzhou, Zhejiang 310058 , China"},{"name":"Zhejiang Lab , Hangzhou 310012 , 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