{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:34:12Z","timestamp":1790184852568,"version":"4.1.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Iron (Fe) is essential for plant development throughout the life cycle. Rosette leaves are responsive to Fe supply in Arabidopsis thaliana. Little is known about the dynamics of Fe deficiency (\u2212Fe) responses of rosette leaves during the reproductive stages. We studied the dynamics of Fe-dependent responses at four consecutive reproductive stages (rosette, bolting, flowering, and mature silique stages, herein named RS, BS, FS, and MS). We examined the growth of rosette leaves, elemental contents, and gene expression patterns of Fe homeostasis genes belonging to differently regulated groups. We determined individual leaf sizes during 7 d of +Fe and \u2212Fe treatment at the RS. Young leaves responded to \u2212Fe with growth inhibition and yellowing. Old and young leaves differed in gene expression patterns and elemental contents. Differences were noted between the early and late reproductive stages (primarily RS and BS versus MS), and correlations between ionomic contents and gene expression were detected. All leaves had induced Fe recycling genes under \u2212Fe. Our findings highlight a developmental stage-dependent modulation of +Fe and \u2212Fe responses in leaves. We discuss possible leaf signaling mechanisms accounting for the distinct responses between old and young leaves. This insight is informative to strengthen our understanding of plant Fe management.<\/jats:p>","DOI":"10.1093\/jxb\/eraf207","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T20:39:20Z","timestamp":1747859960000},"page":"4598-4614","source":"Crossref","is-referenced-by-count":5,"title":["Age-dependent differential iron deficiency responses of rosette leaves during reproductive stages in\n                    <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7307-9563","authenticated-orcid":false,"given":"Mary","family":"Ngigi","sequence":"first","affiliation":[{"name":"Institute of Botany, Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Cluster of Excellence on Plant Science (CEPLAS), Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4141-3106","authenticated-orcid":false,"given":"Mather","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Cluster of Excellence on Plant Science (CEPLAS), Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Division of Plant Science & Technology, C.S. Bond Life Sciences Center, University of Missouri , Columbia, MO 65211 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0647-7934","authenticated-orcid":false,"given":"Ricarda","family":"Remus","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-1597","authenticated-orcid":false,"given":"Shishir K","family":"Gupta","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Cluster of Excellence on Plant Science (CEPLAS), Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-4532","authenticated-orcid":false,"given":"Petra","family":"Bauer","sequence":"additional","affiliation":[{"name":"Institute of Botany, Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Cluster of Excellence on Plant Science (CEPLAS), Heinrich-Heine-University , D-40225 D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"2025100910372516800_eraf207-B1","doi-asserted-by":"crossref","first-page":"e2024918118","DOI":"10.1073\/pnas.2024918118","article-title":"Photoprotection during iron deficiency is mediated by the bHLH transcription factors PYE and ILR3","volume":"118","author":"Akmakjian","year":"2021","journal-title":"Proceedings of the National Academy of Sciences, 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