{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:34:24Z","timestamp":1787798064753,"version":"build-2784847793"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ministry of Agriculture, Israel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The co-evolutionary arms race between crops and their parasites requires continuous identification of new resistance mechanisms. Broomrape (Orobanche cumana), a root parasitic plant, poses a severe threat to sunflower (Helianthus annuus) production, yet the genetic architecture underlying host resistance remains poorly understood. To address this, we established a high-throughput phenotyping platform to quantify root infestation across a diverse sunflower association mapping (SAM) population. Combining this phenotypic resource with a dual genome-wide association study (GWAS) strategy based on both single nucleotide polymorphisms (SNPs) and k-mers, we highlight the genetic basis of broomrape resistance at unprecedented resolution. Our analyses revealed quantitative trait loci (QTLs) and identified novel candidate genes, including putative leucine-rich repeat receptor kinases potentially involved in parasite recognition and defense activation. Importantly, the k-mer approach circumvented reference genome bias and uncovered key genomic introgressions from wild Helianthus relatives that contribute substantially to resistance. These findings demonstrate the utility of integrating high-resolution phenotyping with advanced association mapping to dissect complex host\u2013parasite interactions. Moreover, they emphasize the enduring value of wild germplasm as a reservoir of adaptive variation, providing crop breeders with crucial tools to counter the rapid evolutionary dynamics of parasitic plants.<\/jats:p>","DOI":"10.1093\/jxb\/erag141","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T03:48:13Z","timestamp":1774237693000},"page":"4435-4448","source":"Crossref","is-referenced-by-count":1,"title":["Wild genes to the rescue: high-throughput genomics reveals the wild source of broomrape resistance in sunflower"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-8817","authenticated-orcid":false,"given":"Dana","family":"Sisou","sequence":"first","affiliation":[{"name":"MIGAL Galilee Research Institute , Kiryat Shmona 1101602 ,","place":["Israel"]},{"name":"Department of Phytopathology and Weed Research, Newe Ya\u2019ar Research Center, Agricultural Research Organization (ARO) , Ramat Yishay 30095 ,","place":["Israel"]},{"name":"The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem , Rehovot 7610001 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammam","family":"Ziadna","sequence":"additional","affiliation":[{"name":"Department of Phytopathology and Weed Research, Newe Ya\u2019ar Research Center, Agricultural Research Organization (ARO) , Ramat Yishay 30095 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Eizenberg-Weiss","sequence":"additional","affiliation":[{"name":"MIGAL Galilee Research Institute , Kiryat Shmona 1101602 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Eizenberg","sequence":"additional","affiliation":[{"name":"Department of Phytopathology and Weed Research, Newe Ya\u2019ar Research Center, Agricultural Research Organization (ARO) , Ramat Yishay 30095 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-4634","authenticated-orcid":false,"given":"Sariel","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"MIGAL Galilee Research Institute , Kiryat Shmona 1101602 ,","place":["Israel"]},{"name":"Department of Bioinformatics, Faculty of Sciences and Technology, Tel-Hai University of Kiryat Shmona in the Galilee , Upper Galilee 1220800 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"2026072903362716000_erag141-B1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10681-016-1652-z","article-title":"Genetic study of recessive broomrape resistance in sunflower","volume":"209","author":"Akhtouch","year":"2016","journal-title":"Euphytica"},{"key":"2026072903362716000_erag141-B2","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3390\/genes11090987","article-title":"A systematic review of extreme phenotype strategies to search for rare variants in genetic studies of complex disorders","volume":"11","author":"Amanat","year":"2020","journal-title":"Genes"},{"key":"2026072903362716000_erag141-B3","author":"Andrews","year":"2020"},{"key":"2026072903362716000_erag141-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"Journal of Statistical Software"},{"key":"2026072903362716000_erag141-B5","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nrg2896","article-title":"Towards identifying genes underlying ecologically relevant traits in Arabidopsis thaliana","volume":"11","author":"Bergelson","year":"2010","journal-title":"Nature Reviews. 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