{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:27:10Z","timestamp":1789658830425,"version":"4.0.1"},"reference-count":88,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNRF190"],"award-info":[{"award-number":["DNRF190"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG HA3468\/8-1"],"award-info":[{"award-number":["DFG HA3468\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technische Universit\u00e4t M\u00fcnchen Institute for Advanced Study (TUM-IAS) Hans Fischer Senior Fellowship","id":[{"id":"https:\/\/ror.org\/02kkvpp62","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Auxins are central for plant growth and development and this has been exploited to design herbicides that hijack the auxin transport machinery and signal transduction pathways. Among these are phenoxyacetic acid herbicides that have been used for decades. Increasing structural, biochemical, and physiological evidence converges on a model in which phenoxyacetic acid herbicides exploit the endogenous auxin transport machinery, with both AUXIN-RESISTANT1\/LIKE-AUX1 importers and PIN-FORMED exporters recognizing and transporting these compounds in a manner closely resembling indole-3-acetic acid. Substrate recognition is governed by conserved interactions with the carboxyl group, while affinity and specificity are modulated by hydrophobic interactions with the aromatic moiety, particularly influenced by halogen substitution. Despite this mechanistic similarity, the comparatively low mobility of phenoxyacetic acid herbicides in planta highlights the importance of additional processes such as intracellular sequestration, metabolic conversion, and conjugation, which limit their systemic distribution. Together with the high conservation of the auxin perception machinery, these findings explain why resistance to synthetic auxins predominantly arises through transport- and metabolism-based mechanisms rather than target-site alterations, and they underscore the central role of auxin transporters as key determinants of herbicide activity and selectivity.<\/jats:p>","DOI":"10.1093\/jxb\/erag404","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T11:32:44Z","timestamp":1787484764000},"source":"Crossref","is-referenced-by-count":0,"title":["Hijacking the auxin highway: substrate recognition of phenoxyacetic acid herbicides"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1105-0075","authenticated-orcid":false,"given":"Lukas","family":"Schulz","sequence":"first","affiliation":[{"name":"Plant Physiology and Biophysics, Julius-Maximilians-Universit\u00e4t W\u00fcrzburg (JMU) , W\u00fcrzburg 97074 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7637-4517","authenticated-orcid":false,"given":"Frederik Bonderup","family":"Bech","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus University , Aarhus C 800 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7266-0704","authenticated-orcid":false,"given":"Sarah","family":"Koutnik-Abele","sequence":"additional","affiliation":[{"name":"Plant Systems Biology, School of Life Sciences Weihenstephan, Technical University of Munich , Freising 85354 ,","place":["Germany"]},{"name":"Institute for Advanced Study, Technical University of Munich , Garching 85748 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1862-7357","authenticated-orcid":false,"given":"Thomas 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