{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:48:19Z","timestamp":1792072099730,"version":"4.4.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Xinjiang Talent Development Fund","award":["XJRC-2025-KJ-PY-KJLJ-088"],"award-info":[{"award-number":["XJRC-2025-KJ-PY-KJLJ-088"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360095"],"award-info":[{"award-number":["32360095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2023D01A06"],"award-info":[{"award-number":["2023D01A06"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The desert moss Syntrichia caninervis is one of the most desiccation-tolerant land plants known and thus provides an important system for dissecting the molecular foundations of extreme stress adaptation in early-diverging land lineages. The MYB transcription factor superfamily orchestrates secondary metabolism and stress signaling across plants, yet its lineage-specific evolution and mechanistic deployment in bryophytes remain poorly understood. Here, we identify 65 MYB genes in the S. caninervis genome and show that the family expanded predominantly through dispersed duplication, with no detectable synteny to vascular-plant MYBs, indicating bryophyte-specific neo-functionalization. Integrating phylogenetic clustering, cis-element architecture, and stress-responsive expression profiling, we highlight MYB20, a nuclear-localized, S13-subgroup R2R3-MYB that is rapidly and strongly induced by dehydration and salinity. Heterologous overexpression in Arabidopsis, together with overexpression and RNAi in S. caninervis, demonstrates that ScMYB20 negatively regulates drought and salt tolerance by suppressing antioxidant capacity, osmotic adjustment, and photosynthetic performance, while concomitantly elevating accumulation of reactive oxygen species and malondialdehyde. Mechanistically, ScMYB20 directly binds a TAACCA motif in the ScCHS1 promoter to repress its transcription, and simultaneously sequesters the WD40 protein TRANSPARENT TESTA GLABRA1 (TTG1), a positive transcriptional activator of ScCHS1, thereby antagonizing ScTTG1-mediated activation. Transient ScCHS1 overexpression restores flavonoid accumulation, antioxidant capacity, and stress tolerance. Together, our findings define a dual-repression module (MYB20\u2013TTG1\u2013CHS1) in S. caninervis that fine-tunes flavonoid flux under abiotic stress, and provide evolutionary and mechanistic insights into how R2R3-MYB repressors evolved to balance metabolic investment and stress survival in land plants.<\/jats:p>","DOI":"10.1093\/jxb\/erag450","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:53:20Z","timestamp":1788616400000},"source":"Crossref","is-referenced-by-count":0,"title":["The R2R3-MYB transcription factor MYB20 negatively regulates drought and salt tolerance through a dual-repression of\n                    <i>CHALCONE SYNTHASE-1<\/i>\n                    (\n                    <i>CHS1<\/i>\n                    )-mediated flavonoid biosynthesis in the desert moss\n                    <i>Syntrichia caninervis<\/i>"],"prefix":"10.1093","author":[{"given":"Jiangyuan","family":"Xiao","sequence":"first","affiliation":[{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University , Urumqi, Xinjiang 830017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University , Urumqi, Xinjiang 830017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University , Urumqi, Xinjiang 830017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Yang","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University , Urumqi, Xinjiang 830017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Liang","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University , Urumqi, Xinjiang 830017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-0978","authenticated-orcid":false,"given":"Yigong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University , Urumqi, Xinjiang 830017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"2026101509113760200_erag450-B1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1105\/tpc.113.122069","article-title":"A conserved network of transcriptional activators and repressors regulates anthocyanin pigmentation in eudicots","volume":"26","author":"Albert","year":"2014","journal-title":"The Plant Cell"},{"key":"2026101509113760200_erag450-B2","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1111\/pce.15336","article-title":"ScDREBA5 enhances cold tolerance by regulating photosynthetic and antioxidant genes in the desert moss Syntrichia caninervis","volume":"48","author":"Bai","year":"2025","journal-title":"Plant, Cell & Environment"},{"key":"2026101509113760200_erag450-B3","doi-asserted-by":"crossref","first-page":"W39","DOI":"10.1093\/nar\/gkv416","article-title":"The MEME 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