{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:26:09Z","timestamp":1793701569222,"version":"4.5.1"},"reference-count":106,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005910","name":"AEI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005910","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0912100)"],"award-info":[{"award-number":["2022YFA0912100)"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The MucR\/Ros family are DNA-interacting proteins and pleiotropic regulators of key aspects of the lifecycle in \u03b1-proteobacteria, particularly in plant-associated bacteria. The early finding that MucR\/Ros proteins contain a C-terminal domain resembling the Cys2His2 eukaryotic Zn-finger domain, indicated that MucR\/Ros were classical transcription factors binding to specific DNA sequences. However, the pleiotropic phenotypes displayed by mucR\/ros mutants and the involvement in regulating diverse functions, including cell cycle progression, symbiosis, virulence, motility, and production of cell surface components, point towards MucR\/Ros being global regulators. Structural and functional studies have positioned MucR\/Ros as novel H-NS (Histone-like Nucleoid Structuring)-like proteins in \u03b1-proteobacteria, that bind AT-rich DNA sequences and are able to bridge DNA through formation of higher order oligomers. MucR\/Ros have also been positioned as xenogeneic silencers (XS), with key roles in horizontal gene acquisition and genome evolution. At least one MucR member is reported to bind the bacterial universal second messenger c-di-GMP, what could thus represent an anti-silencing mechanism, as proposed for other bacterial XS. The co-existence of functionally and structurally heterogeneous MucR homologs in the same genome adds further complexity, but it also warrants renewed interest to decipher the multiple roles of MucR in this important group of bacteria.<\/jats:p>","DOI":"10.1093\/jxb\/erag507","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:25:55Z","timestamp":1792409155000},"source":"Crossref","is-referenced-by-count":0,"title":["MucR\/Ros family in plant-associated bacteria: from transcriptional regulators to c-di-GMP effectors"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-8754","authenticated-orcid":false,"given":"Juan","family":"Sanjuan","sequence":"first","affiliation":[{"name":"Department of Soil and Plant Microbiology, Estaci\u00f3n Experimental del Zaid\u00edn-CSIC , Granada 18008 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-3880","authenticated-orcid":false,"given":"Ilaria","family":"Baglivo","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania \u2018Luigi Vanvitelli\u2019 , Caserta 81100 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1284-4510","authenticated-orcid":false,"given":"Javier","family":"Lloret","sequence":"additional","affiliation":[{"name":"Department of Biology, Universidad Aut\u00f3noma de Madrid , Madrid 28049 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-5671","authenticated-orcid":false,"given":"Daniel","family":"P\u00e9rez-Mendoza","sequence":"additional","affiliation":[{"name":"Department of Soil and Plant Microbiology, Estaci\u00f3n Experimental del Zaid\u00edn-CSIC , Granada 18008 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-363X","authenticated-orcid":false,"given":"Chang-Fu","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience, and College of Biological Sciences, China Agricultural University , Beijing 100193 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"2026110304351055100_erag507-B1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1094\/MPMI-06-16-0116-R","article-title":"The Sinorhizobium fredii HH103 MucR1 global regulator is connected with the nod regulon and is required for efficient symbiosis with Lotus burttii and Glycine max cv. 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