{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:18:25Z","timestamp":1781669905355,"version":"3.54.5"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1093\/jxb\/erq211","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T02:03:12Z","timestamp":1278640992000},"page":"3983-3993","source":"Crossref","is-referenced-by-count":36,"title":["Duplicate polyphenol oxidase genes on barley chromosome 2H and their functional differentiation in the phenol reaction of spikes and grains"],"prefix":"10.1093","volume":"61","author":[{"given":"Shin","family":"Taketa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Matsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Amano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Saisho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko","family":"Himi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Shitsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Yuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,7,8]]},"reference":[{"key":"key\n\t\t\t\t20170512115352_bib1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2135\/cropsci2001.1697","article-title":"An improved whole-seed assay for screening of wheat germplasm for polyphenol oxidase activity","volume":"41","author":"Anderson","year":"2001","journal-title":"Crop Science"},{"key":"key\n\t\t\t\t20170512115352_bib2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcs.2006.06.008","article-title":"Biochemical and genetic characterization of wheat (Triticum spp.) kernel polyphenol oxidases","volume":"44","author":"Anderson","year":"2006","journal-title":"Journal of Cereal Science"},{"key":"key\n\t\t\t\t20170512115352_bib3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF00020197","article-title":"An apple polyphenol oxidase cDNA is up-regulated in wounded tissues","volume":"27","author":"Boss","year":"1995","journal-title":"Plant Molecular Biology"},{"key":"key\n\t\t\t\t20170512115352_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00014492","article-title":"Cloning and characterization of cDNAs coding for Vicia faba polyphenol oxidase","volume":"20","author":"Cary","year":"1992","journal-title":"Plant Molecular Biology"},{"key":"key\n\t\t\t\t20170512115352_bib5","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1104\/pp.124.1.285","article-title":"Polyphenol oxidase from hybrid poplar. Cloning and expression in response to wounding and herbivory","volume":"124","author":"Constabel","year":"2000","journal-title":"Plant Physiology"},{"key":"key\n\t\t\t\t20170512115352_bib6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00122-001-0847-3","article-title":"Molecular characterization of wheat polyphenol oxidase (PPO)","volume":"104","author":"Demeke","year":"2002","journal-title":"Theoretical and Applied Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib7","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.2135\/cropsci2001.1750","article-title":"Wheat polyphenol oxidase: distribution and genetic mapping in three inbred line populations","volume":"41","author":"Demeke","year":"2001","journal-title":"Crop Science"},{"key":"key\n\t\t\t\t20170512115352_bib8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1105\/tpc.12.5.637","article-title":"Genome relationships: the grass model in current research","volume":"12","author":"Devos","year":"2000","journal-title":"The Plant Cell"},{"key":"key\n\t\t\t\t20170512115352_bib9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0315-5463(84)72567-3","article-title":"Development of a high extraction flour for the GRL Pilot Mill to evaluate Canadian wheat potential for the Chinese market","volume":"14","author":"Dexter","year":"1984","journal-title":"Canadian Institute of Food Science and Technology Journal"},{"key":"key\n\t\t\t\t20170512115352_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/BF00039560","article-title":"Molecular cloning and characterization of grape berry polyphenol oxidase","volume":"26","author":"Dry","year":"1994","journal-title":"Plant Molecular Biology"},{"key":"key\n\t\t\t\t20170512115352_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2307\/2408678","article-title":"Confidence limits on phylogenies: an approach using the bootstrap","volume":"39","author":"Felsenstein","year":"1985","journal-title":"Evolution"},{"key":"key\n\t\t\t\t20170512115352_bib12","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1021\/jf0526386","article-title":"Delineating the role of polyphenol oxidase in the darkening of alkaline wheat noodles","volume":"54","author":"Fuerst","year":"2006","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"key\n\t\t\t\t20170512115352_bib13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-313X.2008.03694.x","article-title":"Refunctionalization of the ancient rice blast disease resistance gene Pit by the recruitment of a retrotransposon as a promoter","volume":"57","author":"Hayashi","year":"2009","journal-title":"The Plant Journal"},{"key":"key\n\t\t\t\t20170512115352_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00122-007-0539-8","article-title":"Allelic variation of polyphenol oxidase (PPO) located on chromosome 2A and 2D and development of functional markers for the PPO genes in common wheat","volume":"115","author":"He","year":"2007","journal-title":"Theoretical and Applied Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib15","first-page":"119","article-title":"Structural variation of SSPPO genes related to flour color in A-, B-, and D-genome of wheat","volume":"6","author":"Himi","year":"2004","journal-title":"Breeding Research"},{"key":"key\n\t\t\t\t20170512115352_bib16","first-page":"471","article-title":"The influence of total phenols content on antioxidant capacity in the whole grain extracts","volume":"3","author":"Hodzic","year":"2009","journal-title":"European Journal of Scientific Research"},{"key":"key\n\t\t\t\t20170512115352_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00039618","article-title":"cDNA cloning and expression of potato polyphenol oxidase","volume":"21","author":"Hunt","year":"1993","journal-title":"Plant Molecular Biology"},{"key":"key\n\t\t\t\t20170512115352_bib18","first-page":"233","article-title":"Ditelosomic additions of barley chromosomes to wheat","volume-title":"Proceedings of the 6th International Wheat Genetics Symposium","author":"Islam","year":"1983"},{"key":"key\n\t\t\t\t20170512115352_bib19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/hdy.1981.24","article-title":"Isolation and characterization of euplasmic wheat-barley chromosome addition lines","volume":"46","author":"Islam","year":"1981","journal-title":"Heredity"},{"key":"key\n\t\t\t\t20170512115352_bib20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1094\/CCHEM.2004.81.4.481","article-title":"Evaluation of wheat polyphenol oxidase genes","volume":"81","author":"Jukanti","year":"2004","journal-title":"Cereal Chemistry"},{"key":"key\n\t\t\t\t20170512115352_bib21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1139\/gen-41-5-680","article-title":"Development of STS markers closely linked to the vrs1 locus in barley, Hordeum vulgare","volume":"41","author":"Komatsuda","year":"1998","journal-title":"Genome"},{"key":"key\n\t\t\t\t20170512115352_bib22","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1534\/genetics.109.108266","article-title":"Evolutionary dynamics of the genomic region around the blast resistance gene Pi-ta in AA genome Oryza species","volume":"183","author":"Lee","year":"2009","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00425-002-0750-4","article-title":"Overexpression of polyphenol oxidase in transgenic tomato plants results in enhanced bacterial disease resistance","volume":"215","author":"Li","year":"2002","journal-title":"Planta"},{"key":"key\n\t\t\t\t20170512115352_bib24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s001220051062","article-title":"Genomic mapping of defence response genes in wheat","volume":"98","author":"Li","year":"1999","journal-title":"Theoretical and Applied Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib25","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/BF00224088","article-title":"Development of simple sequence repeat DNA markers and their integration into a barley linkage map","volume":"93","author":"Liu","year":"1996","journal-title":"Theoretical and Applied Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jinorgbio.2005.10.008","article-title":"Comparative analysis of polyphenol oxidase from plant and fungal species","volume":"100","author":"Marusek","year":"2006","journal-title":"Journal of Inorganic Biochemistry"},{"key":"key\n\t\t\t\t20170512115352_bib27","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00122-007-0514-4","article-title":"Polyphenol oxidase (PPO) in wheat and wild relatives: molecular evidence for a multigene family","volume":"114","author":"Massa","year":"2007","journal-title":"Theoretical and Applied Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib28","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1016\/j.phytochem.2006.08.006","article-title":"Polyphenol oxidases in plant and fungi: Going places? A review","volume":"67","author":"Mayer","year":"2006","journal-title":"Phytochemistry"},{"key":"key\n\t\t\t\t20170512115352_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkp831","article-title":"SALAD database: a motif-based database of protein annotations for plant comparative genomics","volume":"38","author":"Mihara","year":"2010","journal-title":"Nucleic Acids Research"},{"key":"key\n\t\t\t\t20170512115352_bib30","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1073\/pnas.0611377104","article-title":"Genetic evidence for a second domestication of barley (Hordeum vulgare) east of the Fertile Crescent","volume":"104","author":"Morrell","year":"2007","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"key\n\t\t\t\t20170512115352_bib31","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/BF00023601","article-title":"Organization of the tomato polyphenol oxidase gene family","volume":"21","author":"Newman","year":"1993","journal-title":"Plant Molecular Biology"},{"key":"key\n\t\t\t\t20170512115352_bib32","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/genetics\/120.3.621","article-title":"Genetic applications of an inverse polymerase chain reaction","volume":"120","author":"Ochman","year":"1988","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib33","doi-asserted-by":"crossref","first-page":"9978","DOI":"10.1021\/jf060974w","article-title":"Phenolic compounds of barley grain and their implication in food product deicoloration","volume":"54","author":"Quinde-Axtell","year":"2006","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"key\n\t\t\t\t20170512115352_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10142-005-0144-3","article-title":"Genetic and in silico comparative mapping of the polyphenol oxidase gene in bread wheat (Triticum aestivum L.)","volume":"5","author":"Raman","year":"2005","journal-title":"Functional and Integrative Genomics"},{"key":"key\n\t\t\t\t20170512115352_bib35","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1093\/genetics\/156.4.1997","article-title":"A simple sequence repeat-based linkage map of barley","volume":"156","author":"Ramsay","year":"2000","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib36","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1534\/genetics.107.079491","article-title":"Molecular phylogeography of domesticated barley traces expansion of agriculture in the Old World","volume":"177","author":"Saisho","year":"2007","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170512115352_bib37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1270\/jsbbs.57.29","article-title":"Construction and characterization of a bacterial artificial chromosome (BAC) library from the Japanese malting barley \u2018Haruna Nijo\u2019","volume":"57","author":"Saisho","year":"2007","journal-title":"Breeding Science"},{"key":"key\n\t\t\t\t20170512115352_bib38","first-page":"406","article-title":"The Neighbor\u2013Joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Molecular Biology and Evolution"},{"key":"key\n\t\t\t\t20170512115352_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1105\/tpc.4.2.135","article-title":"The tomato 66.3-kDa polyphenol oxidase gene: molecular identification and developmental expression","volume":"4","author":"Shahar","year":"1992","journal-title":"The Plant Cell"},{"key":"key\n\t\t\t\t20170512115352_bib40","first-page":"763","article-title":"Genetic mapping of polyphenol oxidase in tetraploid wheat","volume":"7","author":"Simeone","year":"2002","journal-title":"Cellular and Molecular Biology Letters"},{"key":"key\n\t\t\t\t20170512115352_bib41","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1104\/pp.104.047449","article-title":"Cloning and characterization of red clover polyphenol oxidase cDNAs and expression of active protein in Escherichia coli and transgenic alfalfa","volume":"136","author":"Sullivan","year":"2004","journal-title":"Plant Physiology"},{"key":"key\n\t\t\t\t20170512115352_bib42","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00023861","article-title":"Inheritance and geographical distribution of phenol reaction-less varieties of barley","volume":"90","author":"Takeda","year":"1996","journal-title":"Euphytica"},{"key":"key\n\t\t\t\t20170512115352_bib43","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1073\/pnas.0711034105","article-title":"Barley grain with adhering hulls is controlled by an ERF family transcription factor gene regulating a lipid biosynthesis pathway","volume":"105","author":"Taketa","year":"2008","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"key":"key\n\t\t\t\t20170512115352_bib44","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software ver. 4.0","volume":"24","author":"Tamura","year":"2007","journal-title":"Molecular Biology and Evolution"},{"key":"key\n\t\t\t\t20170512115352_bib45","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0031-9422(95)00359-F","article-title":"Systemic wound induction of potato (Solanum tuberosum) polyphenol oxidiase","volume":"40","author":"Thipyapong","year":"1995","journal-title":"Phytochemistry"},{"key":"key\n\t\t\t\t20170512115352_bib46","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1104\/pp.113.3.707","article-title":"Differential expression and turnover of the tomato polyphenol oxidase gene family during vegetative and reproductive development","volume":"113","author":"Thipyapong","year":"1997","journal-title":"Plant Physiology"},{"key":"key\n\t\t\t\t20170512115352_bib47","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0031-9422(97)00186-6","article-title":"Sequence and structural features of plant and fungal tyrosinases","volume":"45","author":"van Gelder","year":"1997","journal-title":"Phytochemistry"},{"key":"key\n\t\t\t\t20170512115352_bib48","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1399-3054.1988.tb09180.x","article-title":"Polyphenol oxidase: the chloroplast oxidase with no established function","volume":"72","author":"Vaughn","year":"1988","journal-title":"Physiologia Plantarum"},{"key":"key\n\t\t\t\t20170512115352_bib49","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1745-4514.2003.tb00289.x","article-title":"Physicochemical properties and function of plant polyphenol oxidase: a review","volume":"27","author":"Yoruk","year":"2003","journal-title":"Journal of Food Biochemistry"},{"key":"key\n\t\t\t\t20170512115352_bib50","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1105\/tpc.108.060426","article-title":"Independent loss of function in a polyphenol oxidase in rice: differentiation in grain discoloration between subspecies and the role of positive selection under domestication","volume":"20","author":"Yu","year":"2008","journal-title":"The Plant Cell"},{"key":"key\n\t\t\t\t20170512115352_bib51","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2229-9-94","article-title":"Identification of an extensive gene cluster among a family of PPOs in Trifolium pratense L. (red clover) using a large insert BAC library","volume":"9","author":"Winters","year":"2009","journal-title":"BMC Plant Biology"},{"key":"key\n\t\t\t\t20170512115352_bib52","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-1-4832-2734-4.50017-6","article-title":"Evolutionary divergence and convergence in proteins","volume-title":"Evolving genes and proteins","author":"Zuckerkandl","year":"1965"}],"container-title":["Journal of Experimental Botany"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jxb\/article-pdf\/61\/14\/3983\/16926858\/erq211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T03:46:58Z","timestamp":1635652018000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jxb\/article-lookup\/doi\/10.1093\/jxb\/erq211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,8]]},"references-count":52,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2010,7,8]]},"published-print":{"date-parts":[[2010,9]]}},"URL":"https:\/\/doi.org\/10.1093\/jxb\/erq211","relation":{},"ISSN":["1460-2431","0022-0957"],"issn-type":[{"value":"1460-2431","type":"electronic"},{"value":"0022-0957","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7,8]]}}}