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Their function in combinations of stresses is, however, not known. Arabidopsis HEAT SHOCK FACTOR A4A (HSFA4A) was previously reported to regulate responses to salt and oxidative stresses. Here we show, that the HSFA4A gene is induced by salt, elevated temperature, and a combination of these conditions. Fast translocation of HSFA4A tagged with yellow fluorescent protein from cytosol to nuclei takes place in salt-treated cells. HSFA4A can be phosphorylated not only by mitogen-activated protein (MAP) kinases MPK3 and MPK6 but also by MPK4, and Ser309 is the dominant MAP kinase phosphorylation site. In vivo data suggest that HSFA4A can be the substrate of other kinases as well. Changing Ser309 to Asp or Ala alters intramolecular multimerization. Chromatin immunoprecipitation assays confirmed binding of HSFA4A to promoters of target genes encoding the small heat shock protein HSP17.6A and transcription factors WRKY30 and ZAT12. HSFA4A overexpression enhanced tolerance to individually and simultaneously applied heat and salt stresses through reduction of oxidative damage. Our results suggest that this heat shock factor is a component of a complex stress regulatory pathway, connecting upstream signals mediated by MAP kinases MPK3\/6 and MPK4 with transcription regulation of a set of stress-induced target genes.<\/jats:p>","DOI":"10.1093\/jxb\/erz217","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T19:13:57Z","timestamp":1557774837000},"page":"4903-4918","source":"Crossref","is-referenced-by-count":97,"title":["The mitogen-activated protein kinase 4-phosphorylated heat shock factor A4A regulates responses to combined salt and heat stresses"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-9319","authenticated-orcid":false,"given":"Norbert","family":"Andr\u00e1si","sequence":"first","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Rig\u00f3","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"},{"name":"Department of Plant Biology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zsigmond","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imma","family":"P\u00e9rez-Salam\u00f3","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Royal Holloway, University of London, Egham Hill, Surrey, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Papdi","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Royal Holloway, University of London, Egham Hill, Surrey, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Klement","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alad\u00e1r","family":"Pettk\u00f3-Szandtner","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Imran","family":"Baba","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhan","family":"Ayaydin","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishna","family":"Dasari","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"},{"name":"Department of Biotechnology, Kakatiya University, Warangal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Cs\u00e9pl\u0151","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-9875","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"Szabados","sequence":"additional","affiliation":[{"name":"Biological Research Centre, Temesv\u00e1ri krt 62,Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"2019092421013908700_CIT0001","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrm2938","article-title":"Heat shock factors: integrators of cell stress, development and lifespan","volume":"11","author":"Akerfelt","year":"2010","journal-title":"Nature Reviews. 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