{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:28:21Z","timestamp":1780514901344,"version":"3.54.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Sechenov University Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Sarcosine was postulated in 2009 as a biomarker for prostate cancer (PCa). Here, we assess plasma sarcosine as a biomarker that is complementary to prostate-specific antigen (PSA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Plasma sarcosine was measured using gas chromatography-mass spectrometry (GC-MS) in adults classified as noncancerous controls (with benign prostate hyperplasia [BPH], n = 36), with prostatic intraepithelial neoplasia (PIN, n = 16), or with PCa (n = 27). Diagnostic accuracy was assessed using receiver operating characteristic curve analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Plasma sarcosine levels were higher in the PCa (2.0 \u00b5M [1.3\u20133.3 \u00b5M], P &amp;lt;.01) and the PIN (1.9 \u00b5M [1.2\u20136.5 \u00b5M], P &amp;lt;.001) groups than in the BPH (0.9 \u00b5M [0.6\u20131.4 \u00b5M]) group. Plasma sarcosine had \u201cgood\u201d and \u201cvery good\u201d discriminative capability to detect PIN (area under the curve [AUC], 0.734) and PCa (AUC, 0.833) versus BPH, respectively. The use of PSA and sarcosine together improved the overall diagnostic accuracy to detect PIN and PCa versus BPH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Plasma sarcosine measured by GC-MS had \u201cgood\u201d and \u201cvery good\u201d classification performance for distinguishing PIN and PCa, respectively, relative to noncancerous patients diagnosed with BPH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmaa008","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T20:10:29Z","timestamp":1581451829000},"page":"566-573","source":"Crossref","is-referenced-by-count":22,"title":["Plasma Sarcosine Measured by Gas Chromatography-Mass Spectrometry Distinguishes Prostatic Intraepithelial Neoplasia and Prostate Cancer from Benign Prostate Hyperplasia"],"prefix":"10.1093","volume":"51","author":[{"given":"Pavel A","family":"Markin","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"},{"name":"PhD Program in Nanosciences and Advanced Technologies, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-8814","authenticated-orcid":false,"given":"Alex","family":"Brito","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Moskaleva","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Fodor","sequence":"additional","affiliation":[{"name":"Clinical Hospital, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina V","family":"Lartsova","sequence":"additional","affiliation":[{"name":"University Clinical Hospital, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgeny V","family":"Shpot","sequence":"additional","affiliation":[{"name":"Research Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia V","family":"Lerner","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily Y","family":"Mikhajlov","sequence":"additional","affiliation":[{"name":"University Clinical Hospital, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V","family":"Potoldykova","sequence":"additional","affiliation":[{"name":"Research Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitry V","family":"Enikeev","sequence":"additional","affiliation":[{"name":"Research Institute of Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey V","family":"Lyundup","sequence":"additional","affiliation":[{"name":"Advanced Cell Technologies Department, Institute for Regenerative Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana A","family":"Appolonova","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. 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