{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:16:57Z","timestamp":1769084217151,"version":"3.49.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["16-15-10340"],"award-info":[{"award-number":["16-15-10340"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine whether urine S-adenosylmethionine (SAM) might be an indicator of chronic kidney disease (CKD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We investigated urine levels of SAM and related metabolites (S-adenosylhomocysteine and homocysteine cysteine) in 62 patients (average age, 65.9 years) with CKD (stages II\u2013V).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with stages III\u2013V CKD stages have significantly decreased urine levels and SAM\/S-adenosylhomocysteine ratio and also cysteine\/homocysteine ratio in blood plasma (P &amp;lt;.05), compared with patients with stage II CKD. Urine SAM levels allowed us to distinguish patients with mildly decreased kidney function from those with moderate to severe renal impairment (AUC, 0.791; sensitivity, 85%; specificity, 78.6%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study results demonstrate that urine SAM is a potent biomarker for monitoring renal function decline at early CKD stages. Urine SAM testing confers an additional advantage to healthcare professionals in that it is noninvasive.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmaa034","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T20:31:38Z","timestamp":1589574698000},"page":"47-56","source":"Crossref","is-referenced-by-count":11,"title":["Urine S-Adenosylmethionine are Related to Degree of Renal Insufficiency in Patients with Chronic Kidney Disease"],"prefix":"10.1093","volume":"52","author":[{"given":"Maria Petrovna","family":"Kruglova","sequence":"first","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Vladimirovich","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Danielevich","family":"Virus","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina Olegovna","family":"Bulgakova","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey Segeevich","family":"Samokhin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatolij Nikolaevich","family":"Fedoseev","sequence":"additional","affiliation":[{"name":"City Clinical Hospital No. 24 of Moscow Healthcare Department, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergej Vital\u2019evich","family":"Grachev","sequence":"additional","affiliation":[{"name":"I.M. 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