{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:29:38Z","timestamp":1778581778903,"version":"3.51.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to clarify the distribution characteristics of serum pepsinogen (PG) and Helicobacter pylori in the medical examination population and to explore the relationships of PG level and H. pylori infection status with the high-sensitivity C-reactive protein (hsCRP) level and their significance in health examination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We detected H. pylori infection by C13 urea breath test, the serum pepsinogen I (PGI) and pepsinogen II (PGII) contents were measured by chemiluminescence microparticle immunoassay, and the PGI\/PGII ratio was calculated. In addition, the serum hsCRP level was determined by the Abbott C16000 automatic biochemical analyzer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The PGI and hsCRP levels were significantly higher in men than in women, and the PGII level was slightly higher in men than in women (both P &amp;lt;.05). The PGI, PGII, and hsCRP levels were positively correlated with age (r = 0.210, 0.287, and 0.133, respectively; P &amp;lt;.05), whereas the PGI\/PGII ratio was negatively correlated with age (r = \u20130.190; P &amp;lt;.05). The positive H. pylori infection rate was 30.2% among the patients in this study; H. pylori infection was not related to sex (P &amp;gt;.05), and the difference in age stratification was not statistically significant (P &amp;gt;.05). The abnormal PGI\/PGII ratio in the medical examination population was not correlated with sex (P &amp;gt;.05). In the H. pylori positive infection group, the proportion of PGI\/PGII ratio &amp;lt;3, the PGI and PGII levels were significantly higher than those in the H. pylori negative infection group, and the PGI\/PGII ratio was significantly lower than that in the negative group (both P &amp;lt;.05). The hsCRP level was not associated with H. pylori infection (P &amp;gt;.05), and it was significantly higher in the PGI\/PGII ratio &amp;lt;3 group than in the PGI\/PGII ratio \u22653 group (P &amp;lt;.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The PGI and PGII levels and the PGI\/PGII ratio are correlated with H. pylori infection. The abnormal PGI\/PGII ratio is closely related to H. pylori infection and hsCRP level. Therefore, H. pylori infection status and hsCRP level should be considered when determining atrophic gastritis by the PGI\/PGII ratio.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmaa042","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T19:12:49Z","timestamp":1591125169000},"page":"57-63","source":"Crossref","is-referenced-by-count":5,"title":["Associations of Serum Pepsinogens and <i>Helicobacter Pylori<\/i> Infection with High-Sensitivity C-Reactive Protein in Medical Examination Population"],"prefix":"10.1093","volume":"52","author":[{"given":"Huixing","family":"Liu","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunrong","family":"Fei","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"issue":"20","key":"2021010415100996400_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000010820","article-title":"Low PGI\/PGII ratio as a marker of atrophic gastritis association with nutritional and metabolic status in healthy people","volume":"97","author":"Su","year":"2018","journal-title":"Medicine"},{"issue":"5","key":"2021010415100996400_CIT0002","first-page":"108","article-title":"Relationship between pepsinogen and other tumor markers and gastric cancer","volume":"33","author":"Liu","year":"2018","journal-title":"J Mod Lab Med"},{"issue":"8","key":"2021010415100996400_CIT0003","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1007\/s10620-010-1248-8","article-title":"Serum pepsinogens in gastric cancer screening","volume":"55","author":"Correa","year":"2010","journal-title":"Digest Dis Sci"},{"issue":"48","key":"2021010415100996400_CIT0004","first-page":"6562","article-title":"Serum pepsinogen levels and their influencing factors: a population-based study in 6990 Chinese from North China","volume":"13","author":"Sun","year":"2007","journal-title":"World J Gastroenterol."},{"issue":"3","key":"2021010415100996400_CIT0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1258\/0969141041732184","article-title":"Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening","volume":"11","author":"Dinis-Ribeiro","year":"2004","journal-title":"J Med Screen."},{"issue":"5","key":"2021010415100996400_CIT0006","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/gut.44.5.693","article-title":"Accuracy of screening for gastric cancer using serum pepsinogen concentrations","volume":"44","author":"Kitahara","year":"1999","journal-title":"Gut."},{"issue":"7","key":"2021010415100996400_CIT0007","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.1572-0241.1998.00335.x","article-title":"Correlation of ratio of serum pepsinogen I and II with prevalence of gastric cancer and adenoma in Japanese subjects","volume":"93","author":"Yoshihara","year":"1998","journal-title":"Am J Gastroenterol."},{"issue":"1","key":"2021010415100996400_CIT0008","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MCG.0b013e318135427c","article-title":"Comparison of the validity of three biomarkers for gastric cancer screening: carcinoembryonic antigen, pepsinogens, and high sensitive C-reactive protein","volume":"43","author":"Chung","year":"2009","journal-title":"J Clin Gastroenterol"},{"issue":"4","key":"2021010415100996400_CIT0009","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1158\/1055-9965.EPI-05-0708","article-title":"Plasma C-reactive protein and risk of colorectal cancer in a nested case-control study: Japan Public Health Center-based prospective study","volume":"15","author":"Otani","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"issue":"3","key":"2021010415100996400_CIT0010","first-page":"629","article-title":"The etiology of gastric cancer. 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