{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:26:51Z","timestamp":1782289611707,"version":"3.54.5"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Finnish Society of Clinical Chemistry","award":["23\/2019"],"award-info":[{"award-number":["23\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To provide faster laboratory data reporting, we evaluated the accuracy of Sysmex XN (Sysmex Inc, Kobe, Japan) absolute neutrophil count (ANC) in the presence of analyzer flagging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sysmex XN and manual microscopy ANC were compared with 80 autovalidated control specimens and with 280 study specimens with analyzer flagging regarding immature granulocytes (IG) &amp;gt;3% or other leukocyte abnormalities. Specimens with ambiguous neutrophil clusters were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A slight positive overall method bias was seen for Sysmex XN compared to manual microscopy (n = 280), 0.025 (95% confidence interval [CI], \u20130.023 to 0.069) \u00d7 109\/L. With IG &amp;gt; 10% (n = 123) the bias was larger, but not clinically significant, 0.17 (95% CI, 0.060\u20130.25) \u00d7 109\/L. No clinically significant difference was seen in neutropenic (ANC &amp;lt; 1.5 \u00d7 109\/L) specimens (n = 91), 0.070 (95% CI, \u20130.013 to 0.14) \u00d7 109\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These data indicate that Sysmex XN ANC can be reported in the presence of certain analyzer flagging to improve patient care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmaa058","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T19:15:13Z","timestamp":1593285313000},"page":"168-173","source":"Crossref","is-referenced-by-count":3,"title":["Reporting Sysmex XN Absolute Neutrophil Count in Samples with Leukocyte Analyzer Flagging"],"prefix":"10.1093","volume":"52","author":[{"given":"Anna-Maria","family":"Linko-Parvinen","sequence":"first","affiliation":[{"name":"Laboratory of Haematology, Tykslab, Laboratory Division, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Turkia","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology, Tykslab, Laboratory Division, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"2021031518102628100_CIT0001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13054-015-0778-z","article-title":"The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation","volume":"19","author":"Mare","year":"2015","journal-title":"Crit Care."},{"issue":"8","key":"2021031518102628100_CIT0002","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1182\/blood-2014-02-482612","article-title":"How we evaluate and treat neutropenia in adults","volume":"124","author":"Berliner","year":"2014","journal-title":"Blood."},{"issue":"12","key":"2021031518102628100_CIT0003","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of inflammation: the beginning programs the end","volume":"6","author":"Serhan","year":"2005","journal-title":"Nat Immunol."},{"key":"2021031518102628100_CIT0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-62703-845-4_1","article-title":"The role of neutrophils in the immune system: an overview. 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