{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:18:49Z","timestamp":1740136729372,"version":"3.37.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Acute promyelocytic leukemia (APL) with variant RARA translocation, eg, t(11;17), is not sensitive to all-trans retinoic acid and requires distinct chemotherapy. However, there are some leukemic entities that may mimic aspects of the clinical and\/or laboratory picture of APL and cause confusion because of karyotype nomenclature. Therefore, recognition of such entities may be of therapeutic and prognostic significance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We present 2 cases of acute myeloid leukemia (AML) with t(11;17) that were clinically concerning for APL based primarily on clinical presentation but were ultimately diagnosed as AML with monocytic differentiation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Both leukemias harbored KMT2A translocations, one located near but not involving RARA and the other with SEPT9.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In leukemias that clinically and\/or immunophenotypically mimic APL, identification of specific gene translocations can lead to the correct diagnosis and may carry therapeutic\/prognostic implications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmaa078","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T12:52:05Z","timestamp":1597150325000},"page":"290-296","source":"Crossref","is-referenced-by-count":1,"title":["Monocytic Acute Myeloid Leukemias with KM2TA Translocations to Chromosome 17q that May Clinically Mimic Acute Promyelocytic Leukemia"],"prefix":"10.1093","volume":"52","author":[{"given":"Raisa I","family":"Balbuena-Merle","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut"},{"name":"Pathology and Laboratory Medicine Service, VA Connecticut Healthcare System, West Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A","family":"Tormey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Autumn","family":"DiAdamo","sequence":"additional","affiliation":[{"name":"Department of Genetics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry M","family":"Rinder","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut"},{"name":"Internal Medicine (Hematology), Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-3653","authenticated-orcid":false,"given":"Alexa J","family":"Siddon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"issue":"3","key":"2021050409522789500_CIT0001","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/ccr3.2044","article-title":"Non-acute promyelocytic leukemia variant, acute myeloid leukemia with translocation (11;17)","volume":"7","author":"Altahan","year":"2019","journal-title":"Clin Case Rep."},{"issue":"2","key":"2021050409522789500_CIT0002","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cancergencyto.2004.10.009","article-title":"Two cases of acute myeloid leukemia with t(11;17) associated with varying morphology and immunophenotype: rearrangement of the MLL gene and a region proximal to the RARalpha gene","volume":"159","author":"Kang","year":"2005","journal-title":"Cancer Genet Cytogenet."},{"issue":"1","key":"2021050409522789500_CIT0003","first-page":"74","article-title":"11q23 rearrangements in acute 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