{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:13:37Z","timestamp":1758266017694},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Platelet and erythrocyte agglutination is known to happen in vitro due to EDTA or temperature-induced cold antibodies. Leukocyte agglutination is far less common, and its etiology is not always known. The 2 cases presented herein are of low-grade B-cell lymphomas consistent with splenic marginal-zone lymphoma that presented with lymphocyte agglutination. In Case A, the lymphocyte aggregates were not resolved by warming the sample or by non-EDTA anticoagulation. In Case B, the lymphocyte aggregates were largely resolved by warming the specimen at 37\u00b0C for 15 minutes. The 2 cases presented herein further show that the etiology of lymphocyte aggregation can have multiple causes, even within the same disease process.<\/jats:p>","DOI":"10.1093\/labmed\/lmab010","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T20:09:58Z","timestamp":1611778198000},"page":"e133-e136","source":"Crossref","is-referenced-by-count":3,"title":["Lymphocyte Aggregation in Low-Grade B-Cell Lymphoma"],"prefix":"10.1093","volume":"52","author":[{"given":"Eric A","family":"Walradth","sequence":"first","affiliation":[{"name":"Hematology Oncology Associates of Central New York , East Syracuse, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"issue":"9","key":"2023020517405771200_CIT0001","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1182\/blood-2010-02-267476","article-title":"Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group","volume":"116","author":"Salido","year":"2010","journal-title":"Blood."},{"issue":"3","key":"2023020517405771200_CIT0002","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/ajcp\/103.3.338","article-title":"Ethylenediamine tetraacetic acid-associated leukoagglutination","volume":"103","author":"Deol","year":"1995","journal-title":"Am J Clin Pathol."},{"issue":"3","key":"2023020517405771200_CIT0003","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/jcp.53.3.228","article-title":"Splenic B cell lymphoma with lymphocyte clusters in peripheral blood smears","volume":"53","author":"Shelton","year":"2000","journal-title":"J Clin Pathol."},{"issue":"2","key":"2023020517405771200_CIT0004","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1309\/RHN7D0FRW6W0QKWR","article-title":"Leukocyte aggregation in vitro as a cause of pseudoleukopenia","volume":"39","author":"Yang","year":"2008","journal-title":"Lab Medicine"},{"key":"2023020517405771200_CIT0005","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/labmed\/28.4.247","article-title":"Clinical pathology rounds: erroneous leukocyte counts and cold agglutinins","volume":"28","author":"Bowen","year":"1997","journal-title":"Lab Medicine"},{"issue":"Suppl 1","key":"2023020517405771200_CIT0006","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12288-013-0300-1","article-title":"Cold-induced pseudoneutropenia in human immunodeficiency virus infect: first case report and review of related articles","volume":"30","author":"Goyal","year":"2014","journal-title":"Indian J Hematol Blood Transfus"},{"issue":"1","key":"2023020517405771200_CIT0007","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1182\/asheducation.V2012.1.426.3798535","article-title":"The many faces of marginal zone lymphoma","volume":"2012","author":"Zinzani","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program."},{"key":"2023020517405771200_CIT0008","volume-title":"Small B-Cell Lymphomas. Hematopathology: A volume in Foundations in Diagnostic Pathology","author":"King","year":"2019","edition":"3"}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/52\/5\/e133\/49092449\/lmab010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/52\/5\/e133\/49092449\/lmab010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T17:41:12Z","timestamp":1675618872000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/52\/5\/e133\/6253741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,26]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,4,26]]},"published-print":{"date-parts":[[2021,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmab010","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2021,4,26]]}}}