{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:04:18Z","timestamp":1782795858919,"version":"3.54.5"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Unusual presentations of otherwise common hematopoietic neoplasms are a well-recognized diagnostic challenge. Herein, we present a case study of a previously healthy 64 year old woman with myeloid sarcoma whose diagnosis was delayed by an unusual immunohistochemical staining pattern, including cytokeratin expression, by the neoplastic cells and by possible anchoring bias introduced by radiographic and flow cytometric immunophenotyping reports. This case study emphasizes the need to integrate clinical, radiographic, histologic, and immunophenotyping data for rapid and accurate tissue diagnoses while being wary of the lack of specificity for many common immunophenotypic markers.<\/jats:p>","DOI":"10.1093\/labmed\/lmab025","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T12:17:42Z","timestamp":1614687462000},"page":"100-106","source":"Crossref","is-referenced-by-count":7,"title":["Myeloid Sarcoma Expressing Keratins and Mimicking Carcinoma\u2014Case Report and Literature Review"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5611-0477","authenticated-orcid":false,"given":"Vanessa J","family":"Dayton","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center-Fairview , Minneapolis, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7127-6889","authenticated-orcid":false,"given":"Amy","family":"Beckman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center-Fairview , Minneapolis, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Linden","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center-Fairview , Minneapolis, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"2023020416502930300_CIT0001","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.humpath.2016.12.014","article-title":"Unusual presentation of extramedullary hematopoietic neoplasms in lymph nodes","volume":"62","author":"Dayton","year":"2017","journal-title":"Human Pathol."},{"key":"2023020416502930300_CIT0002","first-page":"116","article-title":"Personality and cognitive considerations","volume-title":"Error Reduction and Prevention in Surgical Pathology.","author":"Volmar","year":"2019","edition":"2"},{"key":"2023020416502930300_CIT0003","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1093\/ajcp\/aqy097.246","article-title":"Aleukemic myeloid sarcoma in female reproductive system: report of two rare cases","volume":"150","author":"Zhang","year":"2018","journal-title":"Am J Clin Path."},{"issue":"11","key":"2023020416502930300_CIT0004","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.leukres.2004.01.022","article-title":"Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution","volume":"28","author":"Breccia","year":"2004","journal-title":"Leuk Res."},{"key":"2023020416502930300_CIT0005","first-page":"403","article-title":"Peripheral T-cell lymphoma, NOS","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Pileri","year":"2017","edition":"4"},{"key":"2023020416502930300_CIT0006","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.5858\/arpa.2014-0295-CC","article-title":"Anaplastic large cell lymphoma, features presenting diagnostic challenges","volume":"138","author":"Pletneva","year":"2014","journal-title":"Arch Path Lab Med."},{"key":"2023020416502930300_CIT0007","first-page":"167","volume-title":"Myeloid sarcoma","author":"Pileri","year":"2017","edition":"4"},{"issue":"2","key":"2023020416502930300_CIT0008","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/sj.leu.2404491","article-title":"Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients","volume":"21","author":"Pileri","year":"2007","journal-title":"Leukemia."},{"issue":"3","key":"2023020416502930300_CIT0009","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1182\/blood-2016-04-712109","article-title":"Cytokeratin-type intermediate filaments in a gastric myeloid sarcoma: a diagnostic pitfall","volume":"128","author":"Schmitt-Graeff","year":"2016","journal-title":"Blood."},{"key":"2023020416502930300_CIT0010","article-title":"The first case of myeloid leukemia\/myeloid sarcoma with cytokeratin expression on blasts diagnosed on urine specimen","author":"Comerford","year":"2020","journal-title":"Hematol Oncol Stem Cell Ther."},{"key":"2023020416502930300_CIT0011","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.5858\/arpa.2014-0061-RA","article-title":"Immunohistochemistry in undifferentiated neoplasm\/tumor of uncertain origin","volume":"138","author":"Fan","year":"2014","journal-title":"Arch Pathol Lab Med"},{"key":"2023020416502930300_CIT0012","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.anndiagpath.2017.04.010","article-title":"Evaluation of CD43 expression in non-hematopoietic malignancies","volume":"29","author":"Batdorf","year":"2017","journal-title":"Ann Diagn Pathol."},{"key":"2023020416502930300_CIT0013","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/ajcp\/104.4.431","article-title":"Extramedullary tumors of lymphoid or myeloid blasts: the role of immunohistology in diagnosis and classification","volume":"104","author":"Quintanilla-Martinez","year":"1995","journal-title":"Am J Clin Path."},{"key":"2023020416502930300_CIT0014","first-page":"468","article-title":"Histiocytic sarcoma.","volume-title":"WHO lassification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th ed","author":"Weis","year":"2017"},{"key":"2023020416502930300_CIT0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1309\/AJCPHY69XVJGULKO","article-title":"Independent diagnostic accuracy of flow cytometry obtained from fine-needle aspirates","volume":"135","author":"Savage","year":"2011","journal-title":"Am J Clin Path."},{"issue":"1","key":"2023020416502930300_CIT0016","doi-asserted-by":"crossref","first-page":"e27453","DOI":"10.1002\/pbc.27453","article-title":"Peripheral blood flow cytometry for the diagnosis of pediatric acute leukemia: highly reliable with rare exceptions","volume":"66","author":"Cheng","year":"2019","journal-title":"Pediatr Blood Cancer."},{"issue":"2","key":"2023020416502930300_CIT0017","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1053\/j.semdp.2017.11.012","article-title":"Immunohistochemistry, carcinomas of unknown primary, and incidence rates","volume":"35","author":"Stelow","year":"2018","journal-title":"Semin Diagn Pathol."},{"key":"2023020416502930300_CIT0018","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5858\/134.2.207","article-title":"Diagnosis of metastatic neoplasms: an immunohistochemical approach","volume":"134","author":"Krishna","year":"2010","journal-title":"Arch Path Lab Med"},{"key":"2023020416502930300_CIT0019","first-page":"10","article-title":"Certainty of S-100 from physiology to pathology","volume":"10","author":"Kuberappa","year":"2016","journal-title":"J Clin Diagnost Res."},{"issue":"6","key":"2023020416502930300_CIT0020","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/PAI.0000000000000436","article-title":"Expression of TLE-1 and CD99 in carcinoma: pitfalls in diagnosis of synovial sarcoma","volume":"26","author":"Zaccarini","year":"2018","journal-title":"Appl Immunohistochem Mol Morphol."},{"issue":"11","key":"2023020416502930300_CIT0021","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.5858\/2009-0165-RSR2.1","article-title":"Merkel cell carcinoma","volume":"134","author":"Wong","year":"2010","journal-title":"Arch Pathol Lab Med."},{"key":"2023020416502930300_CIT0022","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0002-9440(10)63110-0","article-title":"Progression in cutaneous malignant melanoma is associated with distinct expression profiles","volume":"164","author":"Alonso","year":"2004","journal-title":"Am J Path"},{"issue":"20","key":"2023020416502930300_CIT0023","doi-asserted-by":"crossref","first-page":"9328","DOI":"10.1158\/0008-5472.CAN-05-1343","article-title":"A tumorigenic subpopulation with stem cell properties in melanomas","volume":"65","author":"Fang","year":"2005","journal-title":"Cancer Res."},{"issue":"4","key":"2023020416502930300_CIT0024","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/modpathol.2013.162","article-title":"A diagnostic algorithm to distinguish desmoplastic from spindle cell melanoma","volume":"27","author":"Weissinger","year":"2014","journal-title":"Mod Pathol."},{"key":"2023020416502930300_CIT0025","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/modpathol.2015.62","article-title":"Aberrant intermediate filament and synaptophysin expression is a frequent event in malignant melanoma: an immunohistochemical study of 73 cases","volume":"28","author":"Carter","year":"2015","journal-title":"Mod Path"},{"issue":"10","key":"2023020416502930300_CIT0026","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1600-0560.2006.00524.x","article-title":"Immunoreactivity of CD99 in invasive malignant melanoma","volume":"33","author":"Wilkerson","year":"2006","journal-title":"J Cutan Pathol."},{"key":"2023020416502930300_CIT0027","first-page":"291","article-title":"Diffuse large B-cell lymphoma, NOS.","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Gascoyne","year":"2017","edition":"4"},{"issue":"2","key":"2023020416502930300_CIT0028","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/0377-4929.208399","article-title":"Poly immunophenotypic expression in a case of diffuse large B-cell lymphoma","volume":"60","author":"Singh","year":"2017","journal-title":"Indian J Pathol Microbiol."},{"issue":"8","key":"2023020416502930300_CIT0029","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.5858\/arpa.2016-0518-RA","article-title":"Application of immunohistochemistry in undifferentiated neoplasms: a practical approach","volume":"141","author":"Kandukuri","year":"2017","journal-title":"Arch Pathol Lab Med."},{"key":"2023020416502930300_CIT0030","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1440-1827.2005.01893.x","article-title":"CD117 expression in diffuse large B-cell lymphoma: fact or fiction?","volume":"55(11)","author":"Vakiani","year":"2005","journal-title":"Pathol Int"},{"issue":"2","key":"2023020416502930300_CIT0031","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/003130200104312","article-title":"A case of keratin-positive acute myeloid leukemia: a possible role for cytokeratin 19 as a specific epithelial marker","volume":"32","author":"Turner","year":"2000","journal-title":"Pathology."},{"issue":"9","key":"2023020416502930300_CIT0032","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.prp.2016.06.014","article-title":"Clinicopathological features of myeloid sarcoma: report of 39 cases and literature review","volume":"212","author":"Wang","year":"2016","journal-title":"Pathol Res Pract."},{"key":"2023020416502930300_CIT0033","first-page":"153","article-title":"Immunoreactivity of MIC2 (CD99) and terminal deoxynucleotidyl tranferase in bone marrow clot and core specimens of acute myeloid leukemias and myelodysplastic syndromes","volume":"130","author":"Kang","year":"2006","journal-title":"Am J Clin Path."},{"issue":"12","key":"2023020416502930300_CIT0034","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.neo.2018.09.007","article-title":"S100 proteins in acute myeloid leukemia","volume":"20","author":"Brenner","year":"2018","journal-title":"Neoplasia."},{"issue":"8","key":"2023020416502930300_CIT0035","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/modpathol.2013.238","article-title":"Optimized immunohistochemical panel to differentiate myeloid sarcoma from blastic plasmacytoid dendritic cell neoplasm","volume":"27","author":"Sangle","year":"2014","journal-title":"Mod Pathol."}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/53\/1\/100\/49091350\/lmab025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/53\/1\/100\/49091350\/lmab025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T16:51:23Z","timestamp":1675529483000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/53\/1\/100\/6350797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,8,13]]},"published-print":{"date-parts":[[2022,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmab025","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,8,13]]}}}