{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:26:45Z","timestamp":1769009205551,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aims to evaluate the performance of an antigen-based rapid diagnostic test (RDT) for the detection of the SARS-CoV-2 virus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross-sectional study was conducted on 677 patients. Two nasopharyngeal swabs and 1 oropharyngeal swab were collected from patients. The RDT was performed onsite by a commercially available immune-chromatographic assay on the nasopharyngeal swab. The nasopharyngeal and oropharyngeal swabs were examined for SARS-CoV-2 RNA by real-time reverse-transcription quantitative polymerase chain reaction (RT-qPCR) assay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall sensitivity of the SARS-CoV-2 RDT was 34.5% and the specificity was 99.8%. The positive predictive value and negative predictive value of the test were 96.6% and 91.5%, respectively. The detection rate of RDT in RT-qPCR positive results was high (45%) for cycle threshold values &amp;lt;25.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The utility of RDT is in diagnosing symptomatic patients and may not be particularly suited as a screening tool for patients with low viral load. The low sensitivity of RDT does not qualify its use as a single test in patients who test negative; RT-qPCR continues to be the gold standard test.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmab033","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T12:06:52Z","timestamp":1616328412000},"page":"e154-e158","source":"Crossref","is-referenced-by-count":16,"title":["Utility of Antigen-Based Rapid Diagnostic Test for Detection of SARS-CoV-2 Virus in Routine Hospital Settings"],"prefix":"10.1093","volume":"52","author":[{"given":"Preeti","family":"Thakur","sequence":"first","affiliation":[{"name":"Department of Microbiology, Maulana Azad Medical College , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Maulana Azad Medical College , New Delhi , 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Virol."},{"key":"2023020507511832800_CIT0011","doi-asserted-by":"crossref","first-page":"104654","DOI":"10.1016\/j.jcv.2020.104654","article-title":"Urgent need of rapid tests for SARS CoV-2 antigen detection: evaluation of the SD-Biosensor antigen test for SARS-CoV-2","volume":"132","author":"Cerutti","year":"2020","journal-title":"J Clin Virol."},{"issue":"8","key":"2023020507511832800_CIT0012","doi-asserted-by":"crossref","first-page":"e00977-20","DOI":"10.1128\/JCM.00977-20","article-title":"Evaluation of a rapid diagnostic assay for detection of SARS-CoV-2 antigen in nasopharyngeal swabs","volume":"58","author":"Lambert-Niclot","year":"2020","journal-title":"J Clin Microbiol."},{"issue":"9","key":"2023020507511832800_CIT0013","doi-asserted-by":"crossref","first-page":"e01438-20","DOI":"10.1128\/JCM.01438-20","article-title":"Clinical evaluation of self-collected saliva by quantitative reverse transcription-PCR (RT-qPCR), direct RT-qPCR, reverse transcription-loop-mediated isothermal amplification, and a rapid antigen test to diagnose COVID-19","volume":"58","author":"Nagura-Ikeda","year":"2020","journal-title":"J Clin Microbiol."},{"key":"2023020507511832800_CIT0014","doi-asserted-by":"crossref","first-page":"m1808","DOI":"10.1136\/bmj.m1808","article-title":"Interpreting a Covid-19 test result","volume":"369","author":"Watson","year":"2020","journal-title":"BMJ."},{"issue":"3","key":"2023020507511832800_CIT0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41579-020-00461-z","article-title":"Considerations for diagnostic COVID-19 tests","volume":"19","author":"Vandenberg","year":"2021","journal-title":"Nat Rev Microbiol."},{"issue":"1","key":"2023020507511832800_CIT0016","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12985-020-01452-5","article-title":"Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in 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