{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:20:01Z","timestamp":1774430401283,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100015190","name":"Houston Methodist Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acquired von Willebrand disease (avWD) arises because of mechanisms that destroy, decrease, absorb, or clear von Willebrand factor (vWF). A 59-year-old man presented with a 3-year history of recurrent gastrointestinal bleeding. Laboratory workup revealed a prolonged platelet function assay-100. The vWF antigen was decreased, and a low vWF immunofunctional activity\/antigen ratio, low collagen binding\/antigen ratio, and decreased intermediate and high molecular weight multimers were noted. The patient had no high-shear stress conditions, and an antibody-mediated process was suspected. A vWF mixing study showed complete correction of vWF activity, suggesting no direct functional inhibitor. The patient was given a bolus of vWF concentrate with serial measurements of vWF; the vWF half-life was 2.5 hours. The vWF propeptide\/antigen ratio was 4:1, supporting a diagnosis of aVWD resulting from increased antibody-mediated vWF clearance. This case study emphasizes the laboratory\u2019s role in the diagnosis and treatment of rare, overlooked acquired bleeding disorders.<\/jats:p>","DOI":"10.1093\/labmed\/lmab104","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T20:12:19Z","timestamp":1637352739000},"page":"e91-e94","source":"Crossref","is-referenced-by-count":2,"title":["Recurrent Gastrointestinal Bleeding in a Middle-Aged Man"],"prefix":"10.1093","volume":"53","author":[{"given":"Faaria","family":"Gowani","sequence":"first","affiliation":[{"name":"University of Tennessee Health Science Center, Department of Pathology and Laboratory Medicine , Memphis, Tennessee , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Phillips","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital, Department of Pathology and Genomic Medicine , Houston, Texas , 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