{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T07:10:22Z","timestamp":1716016222162},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pseudothrombocytopenia is an in vitro phenomenon of platelet aggregation due to conformational changes and exposure of cryptic antigens on the platelet surface caused by anticoagulants, leading to the aggregation of platelets and falsely lower automated platelet counts. Although it has no clinical relevance, it can lead to unnecessary fear, diagnostic errors, or unnecessary tests and interventions when unrecognized.<\/jats:p>\n               <jats:p>Pseudothrombocytopenia was detected in a 25-year-old woman 8 months after the second dose of mRNA COVID-19 vaccine, BNT162b2. The pseudothrombocytopenia was transient and the duration was shorter than 3 months. As pseudothromobocytopenia is not detected unless blood is drawn for other objectives, it is difficult to determine its true occurrence among recipients of vaccines. This case shows that pseudothrombocytopenia may develop transiently even months after COVID-19 vaccination and should be considered when thrombocytopenia is found in recipients of the vaccine to avoid unnecessary fear, diagnostic errors, or unnecessary tests and interventions.<\/jats:p>","DOI":"10.1093\/labmed\/lmac031","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T12:08:28Z","timestamp":1647000508000},"page":"540-541","source":"Crossref","is-referenced-by-count":1,"title":["Transient Pseudothrombocytopenia Detected 8 Months After COVID-19 Vaccination"],"prefix":"10.1093","volume":"53","author":[{"given":"Takakazu","family":"Higuchi","sequence":"first","affiliation":[{"name":"Blood Transfusion Department, Dokkyo Medical University Saitama Medical Center , Koshigaya , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Dokkyo Medical University Saitama Medical Center , Koshigaya , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astuko","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Dokkyo Medical University Saitama Medical Center , Koshigaya , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Haruki","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Dokkyo Medical University Saitama Medical Center , Koshigaya , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"2022090114002015600_CIT0001","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.thromres.2020.06.008","article-title":"Mechanisms involved in the development of thrombocytopenia in patients with COVID-19","volume":"193","author":"Zhang","year":"2020","journal-title":"Thromb 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pseudothrombocytopenia in a patient with 2019 novel coronavirus pneumonia","volume":"31","author":"Li","year":"2020","journal-title":"Platelets"},{"key":"2022090114002015600_CIT0006","article-title":"EDTA-induced pseudothrombocytopenia up to 9 months after initial COVID-19 infection associated with persistent anti-SARS-CoV-2 IgM\/IgG seropositivity","author":"Bereczki","year":"2021","journal-title":"Lab Med."},{"key":"2022090114002015600_CIT0007","doi-asserted-by":"crossref","first-page":"194","DOI":"10.5152\/balkanmedj.2021.20229","article-title":"Massive platelet clumping on peripheral blood smear and pseudothrombocytopenia in a patient with COVID-19","volume":"38","author":"Can","year":"2021","journal-title":"Balkan Med J"},{"key":"2022090114002015600_CIT0008","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3390\/jcm10040594","article-title":"Pseudothrombocytopenia: a review on causes, occurrence and clinical implications","volume":"10","author":"Lardinois","year":"2021","journal-title":"J Clin Med."},{"key":"2022090114002015600_CIT0009","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/bjh.17645","article-title":"Exacerbation of immune thrombocytopenia following COVID-19 vaccination","volume":"195","author":"Kuter","year":"2021","journal-title":"Br J Haematol"},{"key":"2022090114002015600_CIT0010","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1016\/j.vaccine.2021.04.054","article-title":"Thrombocytopenia including immune thrombocytopenia after receipt of mRNA COVID-19 vaccines reported to the Vaccine Adverse Event Reporting System (VAERS)","volume":"39","author":"Welsh","year":"2021","journal-title":"Vaccine"},{"key":"2022090114002015600_CIT0011","first-page":"1","article-title":"Vaccine-induced pseudothrombocytopenia after Ad26.COV2.S vaccination","author":"Kemper","year":"2021","journal-title":"Ann Hematol."},{"key":"2022090114002015600_CIT0012","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1056\/NEJMoa2110475","article-title":"Safety of the BNT162b2 mRNA Covid-19 vaccine in a nationwide setting","volume":"385","author":"Barda","year":"2021","journal-title":"N Engl J Med"},{"key":"2022090114002015600_CIT0013","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1056\/NEJMc2115045","article-title":"Adverse effects after BNT162b2 vaccine and SARS-CoV-2 infection, according to age and sex","volume":"385","author":"Dagan","year":"2021","journal-title":"N Engl J Med"}],"container-title":["Laboratory 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