{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:33:51Z","timestamp":1778873631634,"version":"3.51.4"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Mayo Clinic COVID-19 Innovation funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Using a US Food and Drug Administration (FDA) emergency use authorization (EUA) reverse transcription polymerase chain reaction (RT-PCR) method, we examined the analytic performance accuracy of saliva specimens as compared to nasopharyngeal (NP) specimens in symptomatic patients. Correlation between test results and symptoms was also evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Over a 5-week period in 2020, 89 matched saliva and nasopharyngeal swabs were collected from individuals exhibiting symptoms consistent with SARS-CoV-2. Specimens were tested with an FDA EUA-approved RT-PCR method, and performance characteristics were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The concordance rate between saliva and nasopharyngeal testing was 93.26%. The mean cycle threshold value of saliva when compared to the NP specimen was 3.56 cycles higher. As compared to NP swab, saliva testing demonstrates acceptable agreement but lower sensitivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>When compared to a reference method using NP swabs, the use of saliva testing proved to be a reliable method. Self-collected saliva testing for SARS-CoV-2 allows for a viable option when trained staff or collection materials are in short supply.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmac051","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T03:58:58Z","timestamp":1649995138000},"page":"580-584","source":"Crossref","is-referenced-by-count":3,"title":["Use of Self-Collected Saliva Samples for the Detection of SARS-CoV-2"],"prefix":"10.1093","volume":"53","author":[{"given":"Kehinde","family":"Sogbesan","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiwo","family":"Sogbesan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-351X","authenticated-orcid":false,"given":"D Jane","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward L","family":"White","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wyeth","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel L","family":"Gasson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan S","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany R","family":"Vicari","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carleen P","family":"Van Siclen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Palmucci","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-3259","authenticated-orcid":false,"given":"Christopher P","family":"Marquez","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Parkulo","sequence":"additional","affiliation":[{"name":"Division of Community, Internal Medicine, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent R","family":"Thielen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6678-9329","authenticated-orcid":false,"given":"Aziza","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Jacksonville, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"issue":"1","key":"2022110311280059400_CIT0001","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.jinf.2020.04.005","article-title":"Saliva is a reliable tool to detect SARS-CoV-2","volume":"81","author":"Azzi","year":"2020","journal-title":"J Infect."},{"issue":"1","key":"2022110311280059400_CIT0002","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jiac.2020.09.027","article-title":"Comparative evaluation of nasopharyngeal swab and saliva specimens for the molecular detection of SARS-CoV-2 RNA in Japanese patients with COVID-19","volume":"27","author":"Sakanashi","year":"2021","journal-title":"J Infect Chemother."},{"key":"2022110311280059400_CIT0003","article-title":"Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization","author":"Planas","year":"2021","journal-title":"Nature."},{"issue":"4","key":"2022110311280059400_CIT0004","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/v13040653","article-title":"Comparison of throat washings, nasopharyngeal swabs and oropharyngeal swabs for detection of SARS-CoV-2","volume":"13","author":"Hitzenbichler","year":"2021","journal-title":"Viruses"},{"issue":"5","key":"2022110311280059400_CIT0005","doi-asserted-by":"crossref","first-page":"e02881","DOI":"10.1128\/JCM.02881-20","article-title":"Performance of saliva, oropharyngeal swabs, and nasal swabs for SARS-CoV-2 molecular detection: a systematic review and meta-analysis","volume":"59","author":"Lee","year":"2021","journal-title":"J Clin Microbiol."},{"key":"2022110311280059400_CIT0006","author":"Golden"},{"key":"2022110311280059400_CIT0007","author":"Centers for Disease Control and Prevention. Overview of testing for SARS-CoV-2 (COVID-19)"},{"issue":"6","key":"2022110311280059400_CIT0008","doi-asserted-by":"crossref","first-page":"e00599","DOI":"10.1128\/JCM.00599-20","article-title":"Clinical evaluation of the cobas SARS-CoV-2 test and a diagnostic platform switch during 48 hours in the midst of the COVID-19 pandemic","volume":"58","author":"Poljak","year":"2020","journal-title":"J Clin Microbiol"},{"issue":"2","key":"2022110311280059400_CIT0009","first-page":"299","article-title":"The disproportional impact of COVID-19 on African Americans","volume":"22","author":"Vasquez Reyes","year":"2020","journal-title":"Health Hum Rights."},{"key":"2022110311280059400_CIT0010"},{"key":"2022110311280059400_CIT0011","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/00333549081230S310","article-title":"Implementing rapid HIV testing in outreach and community settings: results from an advancing HIV prevention demonstration project conducted in seven U.S. cities","volume":"123","author":"Bowles","year":"2008","journal-title":"Public Health Rep."}],"container-title":["Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/53\/6\/580\/46777011\/lmac051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/labmed\/article-pdf\/53\/6\/580\/46777011\/lmac051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T11:39:14Z","timestamp":1667475554000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/labmed\/article\/53\/6\/580\/6603986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,8]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,8]]},"published-print":{"date-parts":[[2022,11,3]]}},"URL":"https:\/\/doi.org\/10.1093\/labmed\/lmac051","relation":{},"ISSN":["0007-5027","1943-7730"],"issn-type":[{"value":"0007-5027","type":"print"},{"value":"1943-7730","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11,1]]},"published":{"date-parts":[[2022,6,8]]}}}