{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:40:51Z","timestamp":1785865251069,"version":"3.56.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T00:00:00Z","timestamp":1660435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Zhejiang Province","award":["LGC21H200004"],"award-info":[{"award-number":["LGC21H200004"]}]},{"name":"Key Research and Development Plan of Zhejiang Province","award":["2019C03028"],"award-info":[{"award-number":["2019C03028"]}]},{"name":"Health Department of Zhejiang Province","award":["2018KY455"],"award-info":[{"award-number":["2018KY455"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Our aim was to investigate the association between gene polymorphisms in catalase (CAT), a well-known oxidative stress regulator, and susceptibility to idiopathic nephrotic syndrome (INS) or responses to steroid therapy in a Chinese pediatric population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed 3 CAT single-nucleotide polymorphisms (SNVs; rs7943316, rs769217, and rs12270780) using multi-polymerase chain reaction combined with next-generation sequencing in 183 INS patients and 100 healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For the allele and genotype frequencies of the CAT SNVs, no significant differences were observed between INS patients and controls. Patients with C allele of CAT rs769217 had a higher risk of developing steroid-dependent nephrotic syndrome than the steroid-sensitive nephrotic syndrome patients (P = 0.018; odds ratio = 1.76).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our data suggests that genetic variations in CAT were unlikely to confer susceptibility to INS in Chinese children, whereas the C allele of the CAT rs769217 polymorphism showed a strong association with steroid-dependent responses in Chinese INS children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmac062","type":"journal-article","created":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T07:48:28Z","timestamp":1660463308000},"page":"35-40","source":"Crossref","is-referenced-by-count":3,"title":["Association of <i>Catalase<\/i> Gene Polymorphisms with Idiopathic Nephrotic Syndrome in a Chinese Pediatric Population"],"prefix":"10.1093","volume":"54","author":[{"given":"Jianrong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center For Child Health , Hangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,14]]},"reference":[{"issue":"4","key":"2023010801582893500_CIT0001","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/20469047.2017.1374003","article-title":"Nephrotic syndrome in infants and children: pathophysiology and management","volume":"37","author":"Downie","year":"2017","journal-title":"Paediatr Int Child Health."},{"issue":"1","key":"2023010801582893500_CIT0002","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pcl.2018.08.006","article-title":"Nephrotic syndrome","volume":"66","author":"Wang","year":"2019","journal-title":"Pediatr Clin North Am."},{"issue":"10141","key":"2023010801582893500_CIT0003","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(18)30536-1","article-title":"Idiopathic nephrotic syndrome in 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