{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:49:17Z","timestamp":1771210157655,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To establish a novel approach for diagnosing endometriosis (EM) in patients with impaired endometrial receptivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Mixed lineage leukemia 1 (MLL1) and enhancer of zeste homolog 2 (EZH2) levels were analyzed. The MLL1:EZH2 ratio in identifying impaired endometrial receptivity has been established and validated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In normal endometrial tissue, the MLL1:EZH2 ratio increased significantly in the midsecretory phase, compared with that in the proliferative phase. In the midsecretory phase, the MLL1:EZH2 ratio in endometrial tissues and uterine secretions accurately identifies patients with EM who have impaired endometrial receptivity. In the validation group, the sensitivity and specificity of the MLL1:EZH2 ratio in the uterine secretions of the midsecretory phase, in diagnosing patients EM who have impaired endometrial receptivity, were 100% and 96.55%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The MLL1:EZH2 ratio in uterine secretions of the midsecretory phase may serve as a marker to diagnose EM in patients with impaired endometrial receptivity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmac067","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T15:54:56Z","timestamp":1662998096000},"page":"90-97","source":"Crossref","is-referenced-by-count":1,"title":["MLL1:EZH2 Ratio in Uterine Secretions and Endometrial Receptivity in Patients with Endometriosis"],"prefix":"10.1093","volume":"54","author":[{"given":"Kehan","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Health, The Maternal and Child Health Hospital of Hunan Province"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Second School of Clinical Medicine, Hunan University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Second School of Clinical Medicine, Hunan University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingfang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Second School of Clinical Medicine, Hunan University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8150-8978","authenticated-orcid":false,"given":"Huizhen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Clinic of Integrated Traditional & Western Medicine, The Maternal and Child Health Hospital of Hunan Province , Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"2023010801582787200_CIT0001","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41574-019-0245-z","article-title":"Rethinking mechanisms, diagnosis and management of endometriosis","volume":"15","author":"Chapron","year":"2019","journal-title":"Nat Rev Endocrinol."},{"key":"2023010801582787200_CIT0002","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3390\/medicina56090460","article-title":"Endometriosis associated infertility: a critical review and analysis on 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