{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:18:58Z","timestamp":1740136738286,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Assays based on redox reactions that involve proton transfer are vulnerable to artifactual findings in metabolic acidosis\/alkalosis. We evaluated the impact of pH on the measurement of blood glucose by the glucose dehydrogenase\/pyrroloquinoline quinone system used in point-of-care-testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We applied a series of thermodynamic equations to adjust the Gibbs energy for the pyrroloquinoline quinone couple. This adjusts values taken under standard conditions to those more closely resembling the physiological state.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Under standard conditions, the pyrroloquinoline quinone couple has Eo = \u22120.125 V whereas adjustment to the physiological state (pH 7.40, ionic strength 0.15 mol\/L, and temperature 310.15\u00b0K) yields Eo\u2032 = \u22120.166 V. This corresponds to an uncertainty in blood glucose determination of approximately 0.13 mmol\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We have demonstrated that the impact of pH on blood glucose determination by the glucose dehydrogenase\/pyrroloquinoline quinone system (under physiologically relevant conditions of ionic strength and temperature) is not clinically significant.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/labmed\/lmac069","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T17:39:53Z","timestamp":1660757993000},"page":"72-74","source":"Crossref","is-referenced-by-count":0,"title":["Pourbiax Diagrams as an Aid to Understanding the Impact of Acid\/Base Disturbance on Blood Glucose Point-of-Care Testing"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-1158","authenticated-orcid":false,"given":"Peter A C","family":"McPherson","sequence":"first","affiliation":[{"name":"School of Science, Engineering & Construction, Belfast Metropolitan College, Titanic Quarter Campus , Belfast , UK"},{"name":"Faculty of Medicine, Health & Life Sciences, Queen\u2019s University Belfast , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen S","family":"McClements","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health & Life Sciences, Queen\u2019s University Belfast , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben M","family":"Johnston","sequence":"additional","affiliation":[{"name":"School of Science, Engineering & Construction, Belfast Metropolitan College, Titanic Quarter Campus , Belfast , 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5\u2032-monophosphate: I, equilibrium model","volume":"40(3)","author":"Goldberg","year":"1991","journal-title":"Biophys Chem"},{"key":"2023010801582278600_CIT0007","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1006\/abbi.2001.2318","article-title":"Standard apparent reduction potentials for biochemical half reactions as a function of pH and ionic strength","volume":"289(1)","author":"Alberty","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"2023010801582278600_CIT0008","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1021\/ed200423n","article-title":"Pourbiax (E-pH-M) diagrams in three dimensions","volume":"89(7)","author":"Pesterfield","year":"2012","journal-title":"J Chem Ed."},{"key":"2023010801582278600_CIT0009","doi-asserted-by":"crossref","first-page":"577","DOI":"10.5858\/2000-124-0577-EOPOGM","article-title":"Effects of pH on glucose measurements with handheld glucose meters and a portable glucose analyzer for point-of-care-testing","volume":"124(4)","author":"Tang","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"2023010801582278600_CIT0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mpmed.2020.11.003","article-title":"Emergencies in diabetes\u2014diabetic ketoacidosis and hyperosmolar hyperglycaemia state","volume":"49(2)","author":"Patel","year":"2021","journal-title":"Medicine"}],"container-title":["Laboratory 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