{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:24:51Z","timestamp":1776194691183,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Molecular testing determines D antigen status when abnormal serologic results are observed. Molecular testing is routinely batched, resulting in longer turnaround time for abnormal D status resolution. During the interim, obstetric patients with questionable\/uninterpretable and weak D typing results by serology, per the immunohematology reference laboratory (IRL) policy, will receive RhD negative blood. This study aimed to determine whether serology results achieved a concordance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hospitals provided samples to the IRL (first IRL) for RhD status by DNA. De-identified samples were sent for serology RhD (second IRL). A concordance of\u2005\u226580% was acceptable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty-nine samples were evaluated. Results were concordant (65.3% [32\/49]) and discordant (34.7% [17\/49]). This is significantly lower than clinically acceptable 80% (z\u2005=\u20052.57, P\u2005&amp;lt;\u2005.05). The turnaround-time was 3.0 hours for serology and 4.4 days for molecular evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Due to a low concordance, serology could not be used in place of molecular testing.<\/jats:p><\/jats:sec>","DOI":"10.1093\/labmed\/lmac097","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T09:07:21Z","timestamp":1663664841000},"page":"190-192","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of RhD Typing Results by Serology and Molecular Methods"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1175-9579","authenticated-orcid":false,"given":"Richard R","family":"Gammon","sequence":"first","affiliation":[{"name":"Scientific, Medical, Technical Direction, OneBlood , Orlando, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Conceicao","sequence":"additional","affiliation":[{"name":"Immunohematology Reference Laboratory, OneBlood , St Petersburg, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Benitez","sequence":"additional","affiliation":[{"name":"Immunohematology Reference Laboratory, OneBlood , Fort Lauderdale, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frieda","family":"Bright","sequence":"additional","affiliation":[{"name":"Centralized Transfusion Service, OneBlood , St Petersburg, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley","family":"Counts","sequence":"additional","affiliation":[{"name":"Information Technology Administration, OneBlood , St Petersburg , FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claribel","family":"Resto","sequence":"additional","affiliation":[{"name":"Immunohematology Reference Laboratory, OneBlood , Fort Lauderdale, FL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Rexer","sequence":"additional","affiliation":[{"name":"Information Technology Administration, OneBlood , St Petersburg , FL, USA"},{"name":"Rexer Analytics , Winchester , MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"key":"2023030723491530600_","article-title":"The Rh system","volume-title":"Technical Manual","author":"Peyrard","year":"2020","edition":"20th"},{"key":"2023030723491530600_","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/trf.12941","article-title":"It\u2019s time to phase in RHD genotyping for patients with a serologic weak D 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