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The SA-SCVs exhibit altered phenotypes as a result of metabolic dormancy caused by electron transport deficiency, leading to increased biofilm production and alterations to antimicrobial susceptibility. The SA-SCVs typically exhibit altered colony morphology and biochemical reactions compared with wild-type SA, making them difficult to detect via routine diagnostics. The SA-SCVs have been found to contribute to chronic or recurrent infections, including skin and soft-tissue infections, foreign-body associated infection, cystic fibrosis, and sepsis. There is evidence that SA-SCVs contribute to patient morbidity and mortality as a result of diagnostic difficulties and limited treatment options. New detection methods may need to be developed that can be incorporated into routine diagnostics, which would allow for better assessment of specimens and introduce new considerations for treatment.<\/jats:p>","DOI":"10.1093\/labmed\/lmac101","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T13:31:14Z","timestamp":1665667874000},"page":"227-234","source":"Crossref","is-referenced-by-count":14,"title":["The Clinical Significance of <i>Staphylococcus aureus<\/i> Small Colony Variants"],"prefix":"10.1093","volume":"54","author":[{"given":"Klara C","family":"Keim","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Campus, University of Colorado , Aurora, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaiah K","family":"George","sequence":"additional","affiliation":[{"name":"Department of Honors Studies, Texas Tech University , Lubbock, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landrye","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Honors Studies, Texas Tech University , Lubbock, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allie C","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Honors Studies, Texas Tech University , Lubbock, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"issue":"3","key":"2023050216515150000_CIT0001","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2133.2008.08437.x","article-title":"Skin microbiota: a source of disease or defence","volume":"158","author":"Cogen","year":"2008","journal-title":"Br J Dermatol."},{"issue":"11","key":"2023050216515150000_CIT0002","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nrmicro.2017.104","article-title":"The 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